The effect of NMDA-NR2B receptor subunit over-expression on olfactory memory task performance in the mouse

White, Theresa L.; Youngentob, Steven L.

doi:10.1016/j.brainres.2004.05.114

Cited by 37 publications

(24 citation statements)

References 25 publications

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“…Mice overexpressing NR2B subunit in forebrain also display enhancement in LTP and learning with respect to control mice in healthy mice (Tang et al, 1999(Tang et al, , 2001White and Youngentob, 2004) as well as in old mice (Cao et al, 2007). Thus, the increase in expression and/or activity of NR2B subunits could improve cognitive capabilities in mice.…”

Section: Discussionmentioning

confidence: 99%

Caloric Restriction Increases Learning Consolidation and Facilitates Synaptic Plasticity through Mechanisms Dependent on NR2B Subunits of the NMDA Receptor

Fontán‐Lozano¹,

Sáez-Cassanelli²,

Inda³

et al. 2007

J. Neurosci.

165

140

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One of the main focal points of aging research is the search for treatments that will prevent or ameliorate the learning and memory deficiencies associated with aging. Here we have examined the effects of maintaining mature mice on a long-term intermittent fasting diet (L-IFD). We found that L-IFD enhances learning and consolidation processes. We also assessed the long-term changes in synaptic efficiency in these animals. L-IFD mice showed an increase in low-theta-band oscillations, paired-pulse facilitation, and facilitation of long-term synaptic plasticity in the hippocampus with respect to mice fed ad libitum. In addition, we found an increase in the expression of the NMDA receptor subunit NR2B in some brain areas of L-IFD mice. Specific antagonism of this subunit in the hippocampus reversed the beneficial effects of L-IFD. These data provide a molecular and cellular mechanism by which L-IFD may enhance cognition, ameliorating some aging-associated cognitive deficits.

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Section: Discussionmentioning

confidence: 99%

Caloric Restriction Increases Learning Consolidation and Facilitates Synaptic Plasticity through Mechanisms Dependent on NR2B Subunits of the NMDA Receptor

Fontán‐Lozano¹,

Sáez-Cassanelli²,

Inda³

et al. 2007

J. Neurosci.

165

140

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“…Remarkably, many forms of learning and memory including those listed above have been found to be modulated by the GluN2A:GluN2B subunit ratio (Buller et al 1994;Tang et al 1999Tang et al , 2001Philpot et al 2001;White and Youngentob 2004;Walker and Davis 2008;Brigman et al 2010;Cui et al 2011Cui et al , 2013Jacobs and Tsien 2012). This ratio is dynamically regulated with the GluN2B subunit being expressed at birth and decreasing with age; while the GluN2A subunit begins to be expressed after birth and increases with age (Hestrin 1992b;Monyer et al 1994;Sheng et al 1994).…”

mentioning

confidence: 99%

“…Increasing the GluN2B:GluN2A subunit ratio, by genetically overexpressing the GluN2B subunit in the forebrain regions, has been found to increase object recognition memory, spatial memory, working memory, and emotional memory in young and aged animals in multiple mammalian species (Tang et al 1999Philpot et al 2001;White and Youngentob 2004;Cao et al 2007;Wang et al 2009;Cui et al 2011). Conversely, decreasing the GluN2B:GluN2A subunit ratio, by genetically overexpressing the GluN2A subunit, significantly impairs long-term object recognition memory, long-term emotional memory, and spatial memory (Cui et al 2013).…”

mentioning

confidence: 99%

“…Conversely, decreasing the GluN2B:GluN2A subunit ratio, by genetically overexpressing the GluN2A subunit, significantly impairs long-term object recognition memory, long-term emotional memory, and spatial memory (Cui et al 2013). Recently, it was demonstrated that the modulation of the GluN2 subunit composition in the NMDA receptor complex also modulated olfactory memory, and social recognition memory (White and Youngentob 2004;Tsien 2012, 2014). Interestingly, genetically increasing the GluN2B:GluN2A subunit ratio increases the ability for the transgenic GluN2B overexpression mice to learn and remember mice of another strain and animals of another rodent species (Jacobs and Tsien 2012).…”

mentioning

confidence: 99%

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Importance of the GluN2B carboxy-terminal domain for enhancement of social memories

Jacobs

Wei²,

Wang³

et al. 2015

Learn. Mem.

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The N-methyl-D-aspartate (NMDA) receptor is known to be necessary for many forms of learning and memory, including social recognition memory. Additionally, the GluN2 subunits are known to modulate multiple forms of memory, with a high GluN2A:GluN2B ratio leading to impairments in long-term memory, while a low GluN2A:GluN2B ratio enhances some forms of long-term memory. Here, we investigate the molecular motif responsible for the differences in social recognition memory and olfactory memory in the forebrain-specific transgenic GluN2A overexpression mice and the forebrain-specific transgenic GluN2B overexpression mice by using two transgenic mouse lines that overexpress chimeric GluN2 subunits. The transgenic chimeric GluN2 subunit mice were tested for their ability to learn and remember fruit scents, male juveniles of the same strain, females of the same strain, male juveniles of another strain, and rodents of another species. The data presented here demonstrate that the GluN2B carboxy-terminal domain is necessary for enhanced social recognition memory in GluN2B transgenic overexpression mice. Furthermore, the GluN2A carboxy-terminal domain is responsible for the impaired long-term olfactory and social memory observed in the GluN2A overexpression mice.

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“…A study done by Bannerman et al (2008) showed that normal Spatial Reference Memory (SRM) in GluN2A-knockout mice was antagonist Ro25-6981 can destroy fear memory in rats aged 3 months, and the effect decreased with age. GluN2B overexpression in mice showed increased learning and memory (White & Youngentob, 2004). These studies on different forms of learning and memory emphasized the importance of GluN2 subunits in learning and memory, and were mainly related to the acquisition of learning and memory.…”

Section: Glun2b and Glun2a Role In Learning And Memorymentioning

confidence: 99%

Investigating the Inhibitory Effect of Fatty Acids on NMDA Receptor

Ma¹,

Chen²

2018

MSHP

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The effect of NMDA-NR2B receptor subunit over-expression on olfactory memory task performance in the mouse

Cited by 37 publications

References 25 publications

Caloric Restriction Increases Learning Consolidation and Facilitates Synaptic Plasticity through Mechanisms Dependent on NR2B Subunits of the NMDA Receptor

Caloric Restriction Increases Learning Consolidation and Facilitates Synaptic Plasticity through Mechanisms Dependent on NR2B Subunits of the NMDA Receptor

Importance of the GluN2B carboxy-terminal domain for enhancement of social memories

Investigating the Inhibitory Effect of Fatty Acids on NMDA Receptor

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