The effect of nitric oxide on fentanyl and haloperidol-induced catalepsy in mice *

Abstract

These results suggest a common mechanism between mu-opioid receptors and the nitric oxide system in the development of fentanyl-induced catalepsy in mice different from haloperidol-induced catalepsy.

S-Nitroso-L-Cysteine Stereoselectively Blunts the Deleterious Effects of Fentanyl on Breathing While Augmenting Antinociception in Freely-Moving Rats

“…For example, there is substantial evidence for nitrosyl factors playing roles in 1) opioid receptor (OR) signaling processes ( Pol, 2007 ; Toda et al, 2009a ; Toda et al, 2009b ; Rodríguez-Muñoz and Garzón, 2013 ), and 2) opioid effects on a) vascular function and reactivity ( Sahin et al, 2005 ; Kaye et al, 2006 ), b) pain processing ( Pelligrino, et al, 1996 ; Maegawa and Tonussi, 2003 ; Cury et al, 2011 ; Hervera et al, 2011 ; Mehanna et al, 2018 ; Ortiz et al, 2020 ), c) vision ( Someya et al, 2017 ), and d) inflammatory-immunoregulatory processes ( Bilfinger, et al, 1998 ; Jan et al, 2011 ). Additionally, nitrosyl factors are involved in opioid-induced catalepsy ( Erkent et al, 2006 ), tolerance to opioids ( Kissin et al, 2000 ; Ozdemir et al, 2011 ; Durmus et al, 2014 ), and fentanyl pre-conditioning ( Lu et al, 2014 ). Nonetheless, only a few studies have sought evidence as to potential roles for nitrosyl factors in the ventilatory depressant effects of opioids.…”

S-nitroso-L-cysteine stereoselectively blunts the adverse effects of morphine on breathing and arterial blood gas chemistry while promoting analgesia

“…The role(s) of nitrosyl factors, such as nitric oxide and S-nitrosothiols, in the pharmacological actions of opioids has received much attention with potential roles for nitrosyl factors being identified in μ-opioid receptor (μ-OR) signaling [ 50 – 53 ], opioid tolerance [ 54 – 56 ], fentanyl pre-conditioning processes [ 57 ], opioid effects within the eye [ 58 ], opioid-induced catalepsy [ 59 ], opioid effects on vascular function [ 60 , 61 ], pain processing [ 62 – 67 ], and inflammatory-immunoregulatory processes [ 68 , 69 ]. There is very limited evidence as to the participation of nitrosyl factors in the ventilatory depressant effects of opioids.…”

Endogenous opiates and behavior: 2009

“…An extract of Papaver rhoeas reduced both the development and expression of morphine-induced sensitization of locomotor activity (982). Fentanylinduced catalepsy was prolonged by both NG-nitro-L-arginine and 7-nitroindazole, effects blocked by L-arginine and naloxone, but not D-arginine (322). GNTI, a KOR antagonist, reduced MK-801-induced hyper locomotion and stereotypy in mice (928).…”