The effect of nigella<i>sativa</i>oil on the prevention of phlebitis induced by chemotherapy: a clinical trial

Behnamfar, Niaz; Yekta, Z Parsa; Mojab, Faraz; Naeini, Seyyed Mohammad Kazem

doi:10.1051/bmdcn/2019090320

Cited by 5 publications

(4 citation statements)

References 33 publications

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“…We selected four human studies (Table 2) that described the effect of N. sativa on human cancer [12][13][14][15]. In three days, Behnamfar et al analyzed the incidence and magnitude of phlebitis, applying N. Sativa by a catheter upon the peripheral vein.…”

Section: Resultsmentioning

confidence: 99%

“…In three days, Behnamfar et al analyzed the incidence and magnitude of phlebitis, applying N. Sativa by a catheter upon the peripheral vein. In their research, they reported that the prevalence of phlebitis in the control group was optimum and that the occurrence of phlebitis in the intervention group was lowest during the 72 hours of the test, assuming that N. sativa oil seemed to have a massive effect on the intervention group [12]. Hussain et al demonstrated the effect of applying N. sativa oil on acute myeloid leukemia.…”

Section: Resultsmentioning

confidence: 99%

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Effects of Black Cumin (Nigella sativa L.) on patients with cancer and tumor: A systematic Review

et al. 2020

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Experimental studies demonstrated a positive effect of administration of Nigella sativa L. (Black cumin) and its active chemical components on cancer and tumor through the antioxidant and anticancer activity. This study aimed to determine the beneficial effect of the use of black cumin in patients with cancer and tumor. This systematic review includes 4 randomized controlled trials that investigated the effect of the administration of black cumin in human cancer. Articles were searched in PubMed, Cochrane library, Semantic scholar and directory of open access journal (DOAJ), open grey and grey literature report databases for studies from 1983 to 2020 before May using the following keywords, Nigella sativa, black cumin, cancer, tumor, etc. The results examined that N. sativa is much effective in treating breast cancer, gastrointestinal cancer, brain tumor, and acute myeloid leukemia. According to the limited evidence from the study, black cumin may have favorable effects on cancer and tumor. However, more research is needed on different types of cancer to confirm and establish the above findings.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Effects of Black Cumin (Nigella sativa L.) on patients with cancer and tumor: A systematic Review

et al. 2020

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“…Phlebitis is an inflammation of the vein caused by chemical, mechanical, or infectious irritation (Gorski, 2017; Higginson & Parry, 2011). Several pharmacological interventions (e.g., nonsteroidal antiinflammatory drugs (NSAIDs) (Berardi et al, 2003), heparin (Ikeda, Douchi, & Nagata, 2004), steroid ointment (Hamabe et al, 2017), and traditional medicines such as Sesame indicum (Bigdeli Shamloo et al, 2019), Nigella sativa (Behnamfar, Parsa Yekta, Mojab, & Kazem Naeini, 2019), and potato (Zhang, Jin, & Wang, 2018)) have been suggested to help reduce incidence of infusion phlebitis and CIP. However, the number of evidences is limited and it is yet unknown what are the most efficient methods.…”

Section: Discussionmentioning

confidence: 99%

Aloe vera and health outcomes: An umbrella review of systematic reviews and meta‐analyses

Sadoyu

Rungruang

Wattanavijitkul

et al. 2020

Phytotherapy Research

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This umbrella review aims to summarize the effects of Aloe vera on health outcomes and assess the strength of evidence. PubMed, Scopus, Embase, Cochrane database of systematic reviews, CINAHL, and AMED were searched from inception to October, 2019 for systematic reviews and meta‐analyses of clinical trials that investigated the effects of Aloe vera on health outcomes. Two independent reviewers extracted data, assessed the methodological quality, and rated the credibility of evidence according to established criteria. Ten articles reporting 71 unique outcomes of Aloe vera were included. Of these, 47 (67%) were nominally statistically significant based on random‐effects model (p ≤ .05). Only 3 outcomes were supported by highly suggestive evidence, whereas 42 outcomes were supported by weak evidence. The highly suggestive evidence supported benefits of Aloe vera in the prevention of second‐degree infusion phlebitis (RR: 0.18, 95% CI: 0.10–0.32, p‐value: 1.75 × 10−9) and chemotherapy‐induced phlebitis based on overall incidence (OR: 0.13, 95% CI: 0.08–0.20, p‐value: 9.68 × 10−20) and incidence of the second degree of severity (OR: 0.10, 95% CI: 0.07–0.14, p‐value: 3.41 × 10−35). However, the majority of the evidence were limited by small sample size and poor methodological quality. Therefore, despite the overall favorable effect of Aloe vera, more robust studies are needed.

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“…Therefore when using intravenous infusion catheters for chemotherapy, nurse must take care of infusion principles such as skin antisepsis, safe maintenance of solutions, and prevention of complications such as air embolism, infection, catheter damage (Behnamfar et al, 2019). The incidence of chemotherapy induced phlebitis in cancer patients ranged from 35% to 56%.…”

Section: Introductionmentioning

confidence: 99%

Effect of Preventive Measures on Chemotherapy Induced Phlebitis among Patients with Cancer

El-Sayad

Aboalizm

Elhy

2023

Menoufia Nursing Journal

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Chemotherapy Induced Phlebitis (CIP) is an unpleasant side effect of peripheral intravenous therapy, particularly after chemotherapy. The nurses take precautions to avoid the development of (CIP). Using Sesame oil and cold compresses can play an important role in reducing CIP. Purpose: To examine the effect of preventive measures on chemotherapy induced phlebitis among patients with cancer. Setting: The study was conducted in the outpatient clinic and the Oncology department of Menoufia University Hospital. Research design: A quasi-experimental (study/control) research design was utilized. Subjects: A consecutive sample of 100 adult patients with cancer of both sexes who were receiving chemotherapy treatment was selected. Instruments: instrument (I): Structured Interview questionnaire: instrument (II): Vein Quality Assessment Tool (VAT), and instrument (III): Visual Infusion Phlebitis (VIP) scale. Results: There was a highly statistical significant difference between both groups related to Chemotherapy Induced phlebitis post intervention (p<0.001). Conclusion: applying Sesame oil and cold compress have positive significant effect on preventing chemotherapy induced phlebitis. Recommendation: Oncology patients should be educated about identifying and reporting any changes in their vein condition. Collaborating with other institutions to implement Sesame oil and cold compresses as a preventive measures to reduce the incidence of (CIP) among patients who were receiving chemotherapy.

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The effect of nigellasativaoil on the prevention of phlebitis induced by chemotherapy: a clinical trial

Cited by 5 publications

References 33 publications

Effects of Black Cumin (Nigella sativa L.) on patients with cancer and tumor: A systematic Review

Effects of Black Cumin (Nigella sativa L.) on patients with cancer and tumor: A systematic Review

Aloe vera and health outcomes: An umbrella review of systematic reviews and meta‐analyses

Effect of Preventive Measures on Chemotherapy Induced Phlebitis among Patients with Cancer

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