The effect of nifedipine therapy on fetal and placental Doppler waveforms in preeclampsia remote from term

Moretti, Michael; Fairlie, Fiona; Akl, Sherif; Khoury, Aldo; Sibai, Bahaeddine M

doi:10.1016/0002-9378(90)90762-v

Cited by 64 publications

(32 citation statements)

References 14 publications

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“…Nifedipine proved to be safe and efficient in pregnancy induced hypertension [18,20,21,22,23]. However, oral nifedipine lowers BP within 20-30 min, with an effect that is not controllable and which lasts up to 3-4 h or even longer [24].…”

Section: Discussionmentioning

confidence: 99%

Short-term treatment of severe hypertension of pregnancy: prospective comparison of nicardipine and labetalol

et al. 2002

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Section: Discussionmentioning

confidence: 99%

Short-term treatment of severe hypertension of pregnancy: prospective comparison of nicardipine and labetalol

et al. 2002

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“…Previous study have demonstrated that nifedipine effectively lowers blood pressure without any apparent reduction in uteroplacental blood flow 4,5 & without any significant heart rate abnormalities. 6,7 These extra benefits of nifedipine also support it as better option for treating the severe PIH patients.…”

Section: Discussionmentioning

confidence: 99%

A randomized trial of intravenous labetalol and oral nifedipine in severe pregnancy induced hypertension

Dhali¹,

Bhattacharya²,

Ganguly³

et al. 2012

Int J Reprod Contracept Obstet Gynecol

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“…She did not receive medication to lower lipids because no controlled studies exist proving the safety of using lipid-lowering drugs during pregnancy 3 . With the diagnosis of preeclampsia, which is associated with reduction in the flow through the uterine artery or the umbilical artery, or both 8 , even though it was classified as a mild form, a concern with assessment of fetal well-being existed, because the patient already had predisposing factors to intrauterine growth retardation, such as the use of beta-blocker 3 and previous arterial disease. We decided to reduce the dose of atenolol and to prescribe nifedipine, which in addition to providing an appropriate control of the blood pressure, does not interfere with the uterus-placenta blood flow 8 .…”

Section: Discussionmentioning

confidence: 99%

Myocardial infarction and subsequent pregnancy

Tedoldi¹,

Manfroi²

2000

Arq. Bras. Cardiol.

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We report the case of a 40-year-old The prevalence of coronary heart disease in women of childbearing age is low when compared with that in men of the same age group. This difference, however, decreases as age increases. Coronary heart disease accounts for 5% of the deaths in women from 35 to 44 years of age in developed countries, such as the United States of America and the United Kingdom 1 . It is estimated that coronary heart disease may complicate 1/10,000 pregnancies and may be potentially lethal for both the mother and the fetus 2,3 . In a series of published cases during the period from 1943 to 1997, 33 pregnancies in women with previous infarction were reported, out of which, 16 were properly investigated 2 . The risks associated with subsequent pregnancies depend on such factors as the status of the coronary anatomy, the presence of myocardial ischemia, and the residual left ventricular function 4 . As reports in the literature about maternal and fetal management and outcome are limited, cardiologists and obstetricians feel insecure about handling these patients.Hypertensive disorder of pregnancy is known to complicate 10% of gestations, causing an increase in maternal and perinatal morbidity and mortality. The incidence of that disorder is increased in patients with previous predisposing factors, such as nulliparity, multifetal gestation, hypertension, and diabetes, previous or familial history of preeclampsia, fetal hydrops, hydatidiform mole 5 . Maternal complications associated with the hypertensive disorder of pregnancy include the following: premature detachment of the placenta, pulmonary edema, respiratory distress, disseminated intravascular coagulation, cerebral hemorrhage, hepatic failure, renal failure . The risk is higher in older women, those with preexisting vascular disease (arterial hypertension, renal disease, type I diabetes mellitus), in multifetal gestations, and in those women with complications in previous pregnancies 6 . Genetic forms of thrombophilia (tendency to the occurrence of thrombosis) are related to adverse gestational results. However, the value of a routine investigation in such cases is questionable 6 . Case ReportA 40-year-old pregnant white female, gravida III (GIII) para II (PII), last delivery 18 years before, with an echographic gestational age of 23 weeks, sought medical care at the high-risk pregnancy unit of the Hospital Nossa Senhora da Conceição. She reported an inferior myocardial infarction at the age of 31 years and an anteroseptal myocardial infarction at the age of 38 years. After the latter event, coronary angiography showed a proximal segmentary lesion occupying 95% of the lumen of the anterior descending artery, a segmentary lesion of 50% in the right coronary artery, and a segmentary lesion of 50% in the medium third of the posterior ventricular branch of the right coronary artery. Ventriculography showed inferior akinesia and anteroapical hypokinesia (figs. 1 to 4). Based on these findings, the patient underwent myocardial revascularization with ...

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The effect of nifedipine therapy on fetal and placental Doppler waveforms in preeclampsia remote from term

Cited by 64 publications

References 14 publications

Short-term treatment of severe hypertension of pregnancy: prospective comparison of nicardipine and labetalol

Short-term treatment of severe hypertension of pregnancy: prospective comparison of nicardipine and labetalol

A randomized trial of intravenous labetalol and oral nifedipine in severe pregnancy induced hypertension

Myocardial infarction and subsequent pregnancy

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