The effect of newly diagnosed undifferentiated connective tissue disease on pregnancy outcome

Spinillo, Arsenio; Beneventi, Fausta; Epis, Oscar Massimiliano; Montanari, Laura; Mammoliti, D; Ramoni, Vèronique; Silverio, Elena Di; Alpini, Claudia; Caporali, Roberto; Montecucco, Carlomaurizio

doi:10.1016/j.ajog.2008.05.008

Cited by 27 publications

(47 citation statements)

References 20 publications

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“…These data confirm previous observations showing that UCTD is the most common newly diagnosed rheumatic condition among young women 22 32. In 10–20% of cases UCTD may progress to an overt SLE or APS over 5 years 6 9 33 34. In our study only two patients with UCTD progressed to a definite disease after 2 years of follow-up (one to SLE, one to APS).…”

Section: Discussionsupporting

confidence: 91%

“…The present 10-item questionnaire has also been tested in a smaller study during the first trimester of pregnancy demonstrating that 10% of screened women who answered positively to at least one question had a 43% prevalence of autoantibody positivity, a 25% prevalence of definite rheumatic disease and an increased prevalence of pregnancy complications 6 9. In the present study, we confirm the usefulness of a two-step approach using a self-administered questionnaire to identify undiagnosed rheumatic diseases among a large series of first trimester pregnant women.…”

Section: Discussionmentioning

confidence: 95%

“…Undifferentiated connective tissue disease (UCTD) may be associated with an increased risk of small for gestational age, preterm delivery, pre-eclampsia and late fetal loss 6. In addition, women with SLE, APS and UCTD have an increased prevalence of circulating anti-Ro/SSA antibodies with an increased risk of congenital heart block (CHB) and neonatal lupus syndrome 6–8…”

mentioning

confidence: 99%

“…In addition, women with SLE, APS and UCTD have an increased prevalence of circulating anti-Ro/SSA antibodies with an increased risk of congenital heart block (CHB) and neonatal lupus syndrome 6–8…”

mentioning

confidence: 99%

“…To identify women at risk we used a two-step approach. The first step was a self-administered questionnaire; the second step included both screening for circulating autoantibodies and rheumatological examination 6 9…”

mentioning

confidence: 99%

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Prevalence and significance of previously undiagnosed rheumatic diseases in pregnancy

et al. 2012

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 95%

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confidence: 99%

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confidence: 99%

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confidence: 99%

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Prevalence and significance of previously undiagnosed rheumatic diseases in pregnancy

et al. 2012

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Pregnancy Outcomes in Undifferentiated Connective Tissue Disease Compared to Systemic Lupus Erythematosus: A Single Academic Center's Experience

Kaufman

Eudy

Harris

et al. 2022

Arthritis Care & Research

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Objective Systemic lupus erythematosus (SLE) patients have more pregnancy complications than healthy patients. Data regarding pregnancy outcomes in women with undifferentiated connective tissue disease (UCTD) are more limited, and existing studies are concentrated in Italy and predominantly in patients with a new diagnosis. Our objective was to compare pregnancy outcomes for UCTD and SLE patients with established disease. Methods Between 2008 and 2017, patients with UCTD and SLE at an academic medical center were recruited to a prospective pregnancy registry. UCTD was defined as a positive autoantibody plus connective tissue disease symptoms not meeting criteria for another rheumatic diagnosis. SLE was defined by American College of Rheumatology or Systemic Lupus International Collaborating Clinics classification criteria or by physician diagnosis. Data were collected throughout pregnancy and postpartum. Comparator groups included UCTD, low‐activity SLE, and high‐activity SLE. Results A total of 150 SLE and 51 UCTD pregnancies were analyzed. Disease activity was low in most patients, although more patients with SLE had severe activity during pregnancy (12% versus 2%; P = 0.05). The frequencies of prematurity and preeclampsia were significantly lower in UCTD than in high‐activity SLE patients (preterm 17% versus 45% [P = 0.004] and preeclampsia 6% versus 34% [P = 0.0008]), although similar to low‐activity SLE patients. More infants who were small for gestational age were born to SLE than UCTD patients (33% versus 7% [P = 0.0005]), regardless of disease activity level. Conclusion Pregnancies in women with UCTD managed by a rheumatologist have a high rate of pregnancy success and fewer risks than those in women with active SLE.

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Uterine artery Doppler velocimetry and obstetric outcomes in connective tissue diseases diagnosed during the first trimester of pregnancy

Beneventi¹,

Locatelli²,

Ramoni³

et al. 2012

Prenatal Diagnosis

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The effect of newly diagnosed undifferentiated connective tissue disease on pregnancy outcome

Cited by 27 publications

References 20 publications

Prevalence and significance of previously undiagnosed rheumatic diseases in pregnancy

Prevalence and significance of previously undiagnosed rheumatic diseases in pregnancy

Pregnancy Outcomes in Undifferentiated Connective Tissue Disease Compared to Systemic Lupus Erythematosus: A Single Academic Center's Experience

Uterine artery Doppler velocimetry and obstetric outcomes in connective tissue diseases diagnosed during the first trimester of pregnancy

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