The effect of neurostimulation applied to the left dorsolateral prefrontal cortex on post-stress adaptation as a function of depressive brooding

Witte, Sara De; Baeken, Chris; Pulopulos, Matías M.; Josephy, Haeike; Schiettecatte, Johan; Anckaert, Ellen; Raedt, Rudi De; Vanderhasselt, Marie‐Anne

doi:10.1016/j.pnpbp.2019.109687

Cited by 24 publications

(30 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For an overview of the study protocol, see Figure 1. Of note, the influence of psychological factors (personality, state anxiety, and rumination) on the effects of iTBS was also assessed and published in Pulopulos et al (2019) and de Witte et al (2020).…”

Section: Methodsmentioning

confidence: 99%

Individual resting‐state frontocingular functional connectivity predicts the intermittent theta burst stimulation response to stress in healthy female volunteers

Wandel

Pulopulos

Labanauskas

et al. 2020

Human Brain Mapping

Self Cite

View full text Add to dashboard Cite

Intermittent theta burst stimulation (iTBS) delivered to the dorsolateral prefrontal cortex (DLPFC) has been investigated as a promising treatment for stress and stressrelated mental disorders such as major depression, yet large individual differences in responsiveness demand further exploration and optimization of its effectiveness. Clinical research suggests that resting-state functional connectivity (rsFC) between the DLPFC and the anterior cingulate cortex (ACC) can predict iTBS treatment response in depression. The present study aimed to investigate whether rsFC between the left DLPFC and ACC subregions could predict the degree to which the stress system is affected by iTBS. After assessment of baseline resting-state fMRI data, 34 healthy female participants performed the Trier Social Stress Test on two separate days, each followed by active or sham iTBS over the left DLPFC. To evaluate iTBS effects on the stress-system, salivary cortisol was measured throughout the procedure. Our results showed that a stronger negative correlation between the left DLPFC and the caudal ACC was linked to a larger attenuation of stress-system sensitivity during active, but not during sham iTBS. In conclusion, based on individual rsFC between left DLPFC and caudal ACC, iTBS could be optimized to more effectively attenuate deregulation of the stress system.

show abstract

Section: Methodsmentioning

confidence: 99%

Individual resting‐state frontocingular functional connectivity predicts the intermittent theta burst stimulation response to stress in healthy female volunteers

Wandel

Pulopulos

Labanauskas

et al. 2020

Human Brain Mapping

Self Cite

View full text Add to dashboard Cite

show abstract

“…The participants were asked to complete a series of questionnaires assessing depression symptoms (Beck Depression Inventory-II;Beck et al 1996;Dutch version: Van der Does, 2002), selfesteem (Rosenberg Self-Esteem Scale; Rosenberg, 1965;Dutch version: Franck et al, 2008), trait and state anxiety (State-Trait Anxiety Inventory; Spielberger et al, 1970;Dutch version: Van der Ploeg, 1980), rumination (Rumination Response Scale; Nolen-Hoeksema and Morrow, 1991); Dutch version: Raes et al, 2003), and perceived stress (Perceived Stress Scale; Cohen et al, 1983) to explore differences between groups since these variables may affect the cortisol response to stress and the effects of rTMS on cortisol secretion (e.g., Chopra et al, 2009;De Witte et al, 2020;Pruessner et al, 2005;Puig-Perez et al, 2016;Salvador and Costa, 2009;Shull et al, 2016;Vrshek-Schallhorn et al, 2018;Zoccola and Dickerson, 2012). The data for baseline questionnaires could not be recorded for one participant.…”

Section: Baseline Questionnairesmentioning

confidence: 99%

The effect of HF-rTMS over the left DLPFC on stress regulation as measured by cortisol and heart rate variability

Pulopulos

Schmaußer

Smet

et al. 2020

Hormones and Behavior

Self Cite

View full text Add to dashboard Cite

The prefrontal cortex, and especially the Dorsolateral Prefrontal Cortex (DLPFC), plays an inhibitory role in the regulation of the Hypothalamic-Pituitary-Adrenal (HPA) axis under stressful situations. Moreover, recent evidence suggests that a sustained DLPFC activation is associated with adaptive stress regulation in anticipation of a stressful event, leading to a reduced stress-induced amygdala response, and facilitating the confrontation with the stressor. However, studies using experimental manipulation of the activity of the DLPFC before a stressor are scarce, and more research is needed to understand the specific role of this brain area in the stress-induced physiological response. This preregistered study investigated the effect on stress regulation of a single excitatory high frequency (versus sham) repetitive transcranial magnetic stimulation (HF-rTMS) session over the left DLPFC applied before the Trier Social Stress Test in 75 healthy young women (M=21.05, SD=2.60). Heart rate variability (HRV) and salivary cortisol were assessed throughout the experimental protocol. The active HF-rTMS and the sham group showed a similar cognitive appraisal of the stress task. No differences in HRV were observed during both the anticipation and the actual confrontation with the stress task and therefore, our results did not reflect DLPFC-related adaptive anticipatory adjustments. Importantly, participants in the active HF-rTMS group showed a lower cortisol response to the stress. The effect of left prefrontal HF-rTMS on the stress system provides further critical experimental evidence for the inhibitory role played by the DLPFC in the regulation of the HPA axis.

show abstract

“…It may be the case that group differences were not significant in this study, as the absolute effect of the paradigms utilized on subjective emotion and state rumination was rather small. In future studies on the effects of mindful emotion regulation, it might be of advantage to use paradigms such as the Trier Social Stress Test 86,87 .…”

Section: Discussionmentioning

confidence: 99%

Neural correlates of mindful emotion regulation in high and low ruminators

Rosenbaum

Kroczek

Hudak

et al. 2020

Sci Rep

View full text Add to dashboard Cite

Depressive rumination is considered a prominent risk factor for the occurrence, severity, and duration of depressive episodes. A variety of treatment options have been developed to treat depressive rumination of which mindfulness based programs are especially promising. In the current study, we investigated the neural underpinnings of a short mindfulness intervention and mindful emotion regulation in high and low trait ruminators in an ecologically valid environment using functional near-infrared spectroscopy (fNIRS). Participants were randomly assigned to a mindfulness instruction (MT) group or an instructed thinking (IT) group. Participants in the MT group were trained to either focus their attention mindfully on their breath or their emotions, while the IT group focused their attention on the past or future. Afterwards, all participants underwent an emotion regulation paradigm in which they either watched negative or neutral movie clips. During both paradigms cortical hemodynamic changes were assessed by means of fNIRS. Participants in the MT group showed lower activity in the cognitive control network (CCN) during the focus on breath condition in comparison to the focus on emotion condition. Additionally, oxygenated hemoglobin in the MT group tended to be lower than in the IT group. Further, self-reports of emotional distress during the instruction paradigm were reduced in the MT group. During the emotion regulation paradigm, we observed reduced emotional reactivity in terms of emotional distress and avoidance in the MT group in comparison to the IT group. Furthermore, on a neural level, we observed higher CCN activity in the MT group in comparison to the IT group. We did not find any effect of rumination, neither on the intervention nor on the emotion regulation task. The results of this pilot study are discussed in light of the present literature on the neural correlates of mindfulness based interventions in rumination and emphasize the use of fNIRS to track neural changes in situ over the course of therapy.

show abstract

The effect of neurostimulation applied to the left dorsolateral prefrontal cortex on post-stress adaptation as a function of depressive brooding

Cited by 24 publications

References 58 publications

Individual resting‐state frontocingular functional connectivity predicts the intermittent theta burst stimulation response to stress in healthy female volunteers

Individual resting‐state frontocingular functional connectivity predicts the intermittent theta burst stimulation response to stress in healthy female volunteers

The effect of HF-rTMS over the left DLPFC on stress regulation as measured by cortisol and heart rate variability

Neural correlates of mindful emotion regulation in high and low ruminators

Contact Info

Product

Resources

About