The Effect of Network Density on the DNA-Sensing Performance of Single-Walled Carbon Nanotubes

Baek, Youn-Kyoung; Yoo, Seung Min; Kim, Ju-Hyun; Jung, Dae-Sung; Choi, Yang‐Kyu; Kim, Yeo Ju; Lee, Sang Yup; Jung, Hee‐Tae

doi:10.1021/jp9080564

Cited by 7 publications

(8 citation statements)

References 28 publications

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“…A complementary DNA sequence is used as the receptor, however, other candidates such as Peptide Nucleic Acids (PNA) have also been evaluated as receptors . At the initial stages, back‐gated field‐effect characteristics were predominantly used as sensor response, as shown in Figure (a) . Furthermore, in most of the cases the incubation strategy was used to obtain the receptors on the entire sensor surface.…”

Section: Performance Merits Of Biodetection Using Carbon Nanostructuresmentioning

confidence: 99%

25th Anniversary Article: Label‐Free Electrical Biodetection Using Carbon Nanostructures

Balasubramanian

Kern

2014

Advanced Materials

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Nanostructures are promising candidates for use as active materials for the detection of chemical and biological species, mainly due to the high surface-to-volume ratio and the unique physical properties arising at the nanoscale. Among the various nanostructures, materials comprised of sp(2) -carbon enjoy a unique position due to the possibility to readily prepare them in various dimensions ranging from 0D, through 1D to 2D. This review focuses on the use of 1D (carbon nanotubes) and 2D (graphene) carbon nanostructures for the detection of biologically relevant molecules. A key advantage is the possibility to perform the sensing operation without the use of any labels or complex reaction schemes. Along this spirit, various strategies reported for the label-free electrical detection of biomolecules using carbon nanostructures are discussed. With their promise for ultimate sensitivity and the capability to attain high selectivity through controlled chemical functionalization, carbon-based nanobiosensors are expected to open avenues to novel diagnostic tools as well as to obtain new fundamental insight into biomolecular interactions down to the single molecule level.

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Section: Performance Merits Of Biodetection Using Carbon Nanostructuresmentioning

confidence: 99%

25th Anniversary Article: Label‐Free Electrical Biodetection Using Carbon Nanostructures

Balasubramanian

Kern

2014

Advanced Materials

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“…Consequently, the current that flows in a single CNT channel is limited to tens of nanoamperes at most, which is similar to the noise level in I D . A simple route to larger I D is to use a random network of CNTs as the channels of CNTFETs. − This configuration offers several advantages: not only higher I D but also higher uniformity. The random network configuration consists of both metallic and semiconducting CNTs.…”

Section: Introductionmentioning

confidence: 99%

Horizontally Aligned Carbon Nanotubes on a Quartz Substrate for Chemical and Biological Sensing

et al. 2012

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We have developed electrolyte-gated sensors based on a fieldeffect transistor (FET) consisting of horizontally aligned single-walled carbon nanotubes (CNTs) synthesized on single-crystal quartz. Dense well-aligned CNTs serving as device channels enabled high current and large transconductance. Owing to these excellent device properties, the pH resolution was much better in the aligned-channel CNTFETs than in single-channel devices. For immunosensing, selective detection of human immunoglobulin E (IgE) by using aptamer-functionalized CNTFETs was demonstrated in the presence of nontarget proteins at much higher concentration. Moreover, measurements of sensor response versus IgE concentration produced data that fit well to the Langmuir adsorption isotherm. The developed sensors with aligned channels exhibited a drain current of 400-fold that of single-channel devices. Therefore, aligned-channel CNTFETs are useful for highly sensitive and practicable solution sensing.

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“…The liquid‐gated configuration has been successful in overcoming this hurdle . Moreover, it has been observed that the specific binding on to CNTs is very limited when using nonspecific incubation protocols . Furthermore, the back‐gated devices were used for sensing without passivating the source and drain electrodes (see Table ).…”

Section: Label‐free Biosensing Strategiesmentioning

confidence: 86%

“…For obtaining individual nanotube electrodes, the CNTs are first dispersed in a surfactant solution (such as sodium dodecyl sulfate or Triton‐X‐100) and subsequently deposited on a substrate by spotting. Using predefined markers on the substrate, they can be located and electrical contacts are made by lithographic procedures . The nanotubes can also be grown directly across the electrical contacts using chemical vapor deposition .…”

Section: Design and Fabricationmentioning

confidence: 99%

“…A). In many cases, the CNT surface contains carboxyl groups, and probe DNA with a terminal amino group is used for the functionalization . The most common linking strategy involves the use of EDC/NHS (1‐ethyl‐3‐(3‐dimethylaminopropyl)carbodiimide hydrochloride/ N ‐hydroxysuccinimide), which activates the carboxyl groups on the nanotube surface, allowing for the coupling to the amino group of the DNA resulting in an amide bond.…”

Section: Chemical Functionalization—immobilization Of Probe Nucleic Acidmentioning

confidence: 99%

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Label‐free indicator‐free nucleic acid biosensors using carbon nanotubes

Balasubramanian¹

2012

Engineering in Life Sciences

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Carbon nanotubes (CNTs) are promising components for electrical biosensors due to their high surface-to-volume ratio and improved electron transfer properties. This review surveys CNT-based label-free indicator-free biosensing strategies that have been demonstrated for the sensitive detection of nucleic acids. After an introduction to CNTs, the fabrication of biosensors and techniques for the immobilization of probe nucleic acids are outlined. Subsequently, two major label-free strategies namely electrochemical transduction and field-effect detection are presented. The focus is on direct detection methods that avoid labels, indicators, intercalating agents, mediators, and even secondary receptors. The review concludes with a comparison between the various biosensors and presents ways of engineering them so that they can be deployed in realistic diagnostic applications.

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The Effect of Network Density on the DNA-Sensing Performance of Single-Walled Carbon Nanotubes

Cited by 7 publications

References 28 publications

25th Anniversary Article: Label‐Free Electrical Biodetection Using Carbon Nanostructures

25th Anniversary Article: Label‐Free Electrical Biodetection Using Carbon Nanostructures

Horizontally Aligned Carbon Nanotubes on a Quartz Substrate for Chemical and Biological Sensing

Label‐free indicator‐free nucleic acid biosensors using carbon nanotubes

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