The effect of naringin, a bioflavonoid on ischemia-reperfusion induced renal injury in rats

Singh, Devinder

doi:10.1016/j.phrs.2004.01.007

Cited by 86 publications

(55 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[25] Thus, ROS are believed to play a central role in I/R injury in addition to several other diseases, including neoplasia, atherosclerosis, and neurodegenerative diseases. [8] ROS are capable of reacting with proteins, lipids, and nucleic acids leading to the lipid peroxidation of biological membranes, which in turn impacts upon enzymatic processes such as ion pump activity [15,26] . Previous experiments show that various exogenous antioxidant agents such as allopurinol, melatonin, tocopherol, leflunomide, and some flavonoids have the potential to reduce I/R induced-renal injury and help the improvement of kidney function.…”

Section: Discussionmentioning

confidence: 99%

“…Previous experiments show that various exogenous antioxidant agents such as allopurinol, melatonin, tocopherol, leflunomide, and some flavonoids have the potential to reduce I/R induced-renal injury and help the improvement of kidney function. [10,[13][14][15]26] In this study, we used AA as an exogenous antioxidant. AA is one of the water-soluble vitamins and is well known as a strong antioxidant agent.…”

Section: Discussionmentioning

confidence: 99%

“…[3,14] Additionally, N-acetylcysteine, α-tocopherol, and melatonin administered to rats following I/R decrease the ROS levels providing kidney damage protection. [2,3,[13][14][15] Several experimental studies suggest that antioxidant vitamins, including ascorbic acid (AA), produce cytoprotective effects due to reduction of ROS. [16] Thus, AA is a very powerful antioxidant agent.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The Protective Effects of Ascorbic Acid against Renal Ischemia-Reperfusion Injury in Male Rats

Korkmaz

Kolankaya

2009

Renal Failure

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Protective Effects of Ascorbic Acid against Renal Ischemia-Reperfusion Injury in Male Rats

Korkmaz

Kolankaya

2009

Renal Failure

View full text Add to dashboard Cite

“…After fifteen days of stobadine derivative medication biochemical markers in blood almost reached the physiological levels. In the similar type of study 3 the reperfusion period lasted only 24 hours and thus the differences between groups treated with flavonoid naringin and the sham groups were much more significant. On the other hand, biochemical markers in urine showed still significant differences (p ≤ 0.05 or p ≤ 0.01) between treated and placebo or intact groups.…”

Section: Discussionmentioning

confidence: 93%

“…Free radicals play an important role in the pathogenesis of kidney ischemia-reperfusion injury 3 . In our study, the antioxidative action of stobadine derivative in the conditions of kidney ischaemia-reperfusion in the laboratory rat was analysed.…”

Section: Discussionmentioning

confidence: 99%

Influence of Antioxidant Effect of Stobadine Derivative in Condition of Kidney Ischemia-Reperfusion in a Pre-Clinical Experiment (Effect in Therapy)

Bartošíková¹,

Nečas²,

Beneš³

et al. 2005

BIOMED PAP

View full text Add to dashboard Cite

The goal of the study was to monitor the antioxidative effect of stobadine derivative under conditions of ischemiareperfusion of laboratory rat kidney tissue. 40 animals were subjected to kidney tissue ischemia (60 min) followed by reperfusion (10 min). After that, the animals were divided by random selection into 4 groups (n = 10). The treated groups were given stobadine derivative in peroral doses of 5, 10 and 20 mg/kg in 0.5% solution of Avicel once a day, the placebo group was given only the solution of Avicel. One group (n = 10) was an intact group (without ischemiareperfusion and without treatment), for comparison. Once a week, selected laboratory parameters were determined in all animals. On the 15 th day the animals were exsanquined and organs were recovered for histopathological examination. We discovered a statistically significant changes of the superoxiddismutase and glutathione peroxidase catalytic activity; changes of total antioxidative capacity and malondialdehyde in the treated groups compared to the groups of placebo and intact. Other examined laboratory parameters (creatinine, urea and uric acid in blood; creatinine, urea, total protein in urine; diuresis) exhibited significant changes too. The results of biochemical examination show a protective antioxidative effect of the compound studied. The results of histopathological examination support this assumption.

show abstract

Reactive Oxygen Species‐Scavenging Nanomedicines for the Treatment of Oxidative Stress Injuries

Yoshitomi

Nagasaki

2014

Adv Healthcare Materials

View full text Add to dashboard Cite

This Progress Report describes a development of two types of reactive oxygen species (ROS)-scavenging nanomedicines for the treatment of oxidative stress injuries, referred to as pH-sensitive redox nanoparticle (RNP(N) ) and pH-insensitive redox nanoparticle (RNP(O) ), which are prepared by self-assembling amphiphilic block copolymers possessing nitroxide radicals as a side chain of hydrophobic segment via amine and ether linkages, respectively. Due to a protonation of amino groups in hydrophobic core, RNP(N) disintegrates in low pH environments such as ischemic, inflamed, and tumor tissues, resulting in increased ROS-scavenging activity because of the exposed nitroxide radicals from the core. Utilizing pH-responsiveness of RNP(N) , it shows remarkable therapeutic effects on oxidative stress injuries such as renal and cerebral ischemia-reperfusion injuries after intravenous administration. Moreover, RNP(N) shows an enhancement of the activity of anticancer drugs by suppression of activation of transcription factors in tumor due to the ROS scavenging. On the other hand, orally administered RNP(O) has notable characteristics such as preferential accumulation in mucosa and inflamed area of gastrointestinal tract and no uptake into blood stream. Based on these characters, RNP(O) shows a remarkable therapeutic effect for the gastrointestinal inflammation without any adverse effects. Thus, ROS-scavenging nanomedicines have therapeutic efficacy in numerous oxidative stress diseases.

show abstract

The effect of naringin, a bioflavonoid on ischemia-reperfusion induced renal injury in rats

Cited by 86 publications

References 54 publications

The Protective Effects of Ascorbic Acid against Renal Ischemia-Reperfusion Injury in Male Rats

The Protective Effects of Ascorbic Acid against Renal Ischemia-Reperfusion Injury in Male Rats

Influence of Antioxidant Effect of Stobadine Derivative in Condition of Kidney Ischemia-Reperfusion in a Pre-Clinical Experiment (Effect in Therapy)

Reactive Oxygen Species‐Scavenging Nanomedicines for the Treatment of Oxidative Stress Injuries

Contact Info

Product

Resources

About