The effect of Nanobone® in combination with platelet rich fibrin on bone regeneration following enucleation of large mandibular cysts

Eldibany, Riham M.; Shokry, Mohamed

doi:10.1016/j.tdj.2014.06.003

Cited by 10 publications

(6 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The present study revealed complete healing of the defects in all dogs with new bone formation without the need to use a membrane. This result was in agreement with EL Dibany and Shoukry (26) in 2014 where the combined use of Nanobone® and PRF for bone regeneration following the enucleation of large mandibular odontogenic cysts induced accelerated bone healing and improved the quality and quantity of regenerated bone also without using a membrane.…”

Section: Discussionsupporting

confidence: 90%

A Comparative Study Between Porous Titanium Granules and Nanocrystalline Hydroxyapatite in Healing of Mandibular Defects in Dogs

Ahmed

Mahmoud

Shafik

et al. 2015

Alexandria Dental Journal

View full text Add to dashboard Cite

Background: Bone grafting is a common technique in Oral and Maxillofacial surgery to replace missing bone. Grafting materials include autografts, allografts, xenografts and synthetic bone substitutes. Two synthetic bone materials are currently available; porous titanium granules and nanocrystalline hydroxyapatite. Objectives: This study compared the use of Porous titanium granules (PTG) versus Nanobone® in healing of mandibular defects in dogs and this was estimated by histological and histomorphometric analysis. Materials and Methods: The study was conducted on 10 healthy experimental dogs. An osseous defect of 10mm depth and 10mm width was created in the premolar area of both right and left sides of the mandible. The right side defects were grafted with PTG while the left side defects were grafted with Nanobone®. Histological and histomorphometrical evaluation was carried out to monitor bone healing and quantify the bone volume with both PTG and Nanobone® at 3, 6 and 12 weeks intervals post-operatively. Results: The mean bone volume value with PTG was 773.4 ± 499.4 on the 3rd week, then increased on the 6th week to be 10125.3 ± 19287.3 and 2676.0 ± 1388.2 on the 12th week. The mean bone volume value with Nanobone® was 525.5 ± 332.1 on the 3rd week, then on the 6th week it became 287.4 ± 322.5. There was a statistically significant increase on the 12th to be 1976.8 ± 1568.1.. There was a statistically significant difference regarding the mean bone volume value between the two groups. Conclusion: Both PTG and Nanobone® have osteoconductive properties and are effective in healing bone defects, but the histomorphometric analysis quantified the bone volume with both PTG and Nanobone® and revealed that the maximum amount of the total regenerated bone was seen in the PTG group; bone was formed within its porosities

show abstract

Section: Discussionsupporting

confidence: 90%

A Comparative Study Between Porous Titanium Granules and Nanocrystalline Hydroxyapatite in Healing of Mandibular Defects in Dogs

Ahmed

Mahmoud

Shafik

et al. 2015

Alexandria Dental Journal

View full text Add to dashboard Cite

show abstract

“…The rate of increase of the bone density and decrease in the surface area of the bone defects is significantly superior to other studies where the defects were left to heal spontaneously without bone graft. [26] The same results were obtained by Nacopaulos et al in 2014 who evaluated the effect of L-PRF in combination with synthetic materials for bone regeneration in rabbits. They showed higher cortical and subcortical bone formation when PRF was combined with synthetic materials than PRF alone and Elgendy et al in 2015 who showed that nHA in combination with L-PRF, had clinical advantages and increased bone gain and density over the use of nHA alone and [27,28] In intra bony defect therapy, PRF was found to be beneficial for bone formation.…”

Section: Discussionsupporting

confidence: 66%

Comparing the effect of Leukocyte PRF (L-PRF) and Advanced PRF(A-PRF) added to nanohydroxyapatite on osseous regeneration after maxillary cyst enucleation (Randomized controlled trial)

Elsakka,

Taha,

Nabil

et al. 2024

OMX

View full text Add to dashboard Cite

Purpose: To assess the difference between the effect of Leukocyte PRF (L-PRF) and Advanced PRF(A-PRF) added to nano hydroxyapatite bone graft on osseous regeneration after cyst enucleation. Methodology: This clinical study was a Randomized Controlled Trial on 21 patients seeking treatment of maxillary cyst and randomly allocated into 3 groups each group containing 7 patients. In group A, a blood sample was collected for preparation of A-PRF and added to nano hydroxyapatite bone graft to fill the bony defect after cyst enucleation. In group B, L-PRF was prepared and added to nanobone to fill the defect. While group C was a negative control group with no grafting of residual defect. Results: Regarding CT preoperative and postoperative volumetric measurements of the defect, there was a significant difference between different groups (p=0.002). Defect volume was reduced by 80.72% in group A followed by group B which reduced by 62.36% then group C reduced by 21.49 %.Also, there was increase in bone density by 78.56% in group A followed by group B increased by 53.70% while in group C increased by 21.49%.And also, there was 78.64% reduction in size of the residual defect in group A followed by group B reduced by 66.20% and the least group was group C reduced by 48.60%. Conclusion: A-PRF/nanobone mixture accelerated bone healing and improved both quality and quantity of regenerated bone in residual defects compared to L-PRF/ Nanobone mixture and control groups. And outcomes of L-PRF/ Nanobone mixture were better than control group.

show abstract

“…Further studies in human subjects have found that NanoBone TM can preserve alveolar bone height at extraction sites. When used with platelet-rich fibrin, it can accelerate bone regeneration and improve the quality and quantity of newly formed bone following excision of mandibular cysts ( Table 2 ) [ 170 , 171 ].…”

Section: Classification Of Dental Bone Graft and Substitute Materialsmentioning

confidence: 99%

Bone Grafts and Substitutes in Dentistry: A Review of Current Trends and Developments

et al. 2021

View full text Add to dashboard Cite

After tooth loss, bone resorption is irreversible, leaving the area without adequate bone volume for successful implant treatment. Bone grafting is the only solution to reverse dental bone loss and is a well-accepted procedure required in one in every four dental implants. Research and development in materials, design and fabrication technologies have expanded over the years to achieve successful and long-lasting dental implants for tooth substitution. This review will critically present the various dental bone graft and substitute materials that have been used to achieve a successful dental implant. The article also reviews the properties of dental bone grafts and various dental bone substitutes that have been studied or are currently available commercially. The various classifications of bone grafts and substitutes, including natural and synthetic materials, are critically presented, and available commercial products in each category are discussed. Different bone substitute materials, including metals, ceramics, polymers, or their combinations, and their chemical, physical, and biocompatibility properties are explored. Limitations of the available materials are presented, and areas which require further research and development are highlighted. Tissue engineering hybrid constructions with enhanced bone regeneration ability, such as cell-based or growth factor-based bone substitutes, are discussed as an emerging area of development.

show abstract

The effect of Nanobone® in combination with platelet rich fibrin on bone regeneration following enucleation of large mandibular cysts

Cited by 10 publications

References 29 publications

A Comparative Study Between Porous Titanium Granules and Nanocrystalline Hydroxyapatite in Healing of Mandibular Defects in Dogs

A Comparative Study Between Porous Titanium Granules and Nanocrystalline Hydroxyapatite in Healing of Mandibular Defects in Dogs

Comparing the effect of Leukocyte PRF (L-PRF) and Advanced PRF(A-PRF) added to nanohydroxyapatite on osseous regeneration after maxillary cyst enucleation (Randomized controlled trial)

Bone Grafts and Substitutes in Dentistry: A Review of Current Trends and Developments

Contact Info

Product

Resources

About