The effect of nano curcumin on oxidative stress in cystic fibrosis patients

Talebi, Saeedeh; Kianifar, Hamid Reza; Safarian, Mohamad; Sayedi, Seyed Javad; Jaafari, M. R.

doi:10.1016/j.clnesp.2021.09.397

Cited by 1 publication

(2 citation statements)

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“…In a double‐blind clinical trial, 50 individuals with CF were recruited, and received either nano‐curcumin or a placebo. These authors found that nano‐curcumin may be beneficial for people with CF by lowering oxidative stress 82 . Along the lines of oxidative stress, others have conducted in vitro studies to determine the role of iron species (e.g., Fe 3+ ) as it pertains to curcumin's potentiating effect on CFTR activation, since it is well known that iron species can participate in the Fenton, or Fenton‐like reactions, to generate oxidizing species that can induce oxidative damage to biomolecules.…”

Section: Herbal Medicinementioning

confidence: 99%

“…These authors found that nano-curcumin may be beneficial for people with CF by lowering oxidative stress. 82 Along the lines of oxidative stress, others have conducted in vitro studies to determine the role of iron species (e.g., Fe 3+ ) as it pertains to curcumin's potentiating effect on CFTR activation, since it is well known that iron species can participate in the Fenton, or Fenton-like reactions, to generate oxidizing species that can induce oxidative damage to biomolecules. For instance, using HEK-293T cells cultured in an Fe 3+ -containing medium and transiently transfected with CFTR constructs, Wang et al 83 investigated the role of the inhibitory Fe 3+ bridge between ICL3 and the R domain, as well as any effect(s) that curcumin may have on this pathway.…”

Section: Curcuminmentioning

confidence: 99%

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Therapeutic potential of phytochemicals for cystic fibrosis

et al. 2023

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The aim of this review was to review and discuss various phytochemicals that exhibit beneficial effects on mutated membrane channels, and hence, improve transmembrane conductance. These therapeutic phytochemicals may have the potential to decrease mortality and morbidity of CF patients. Four databases were searched using keywords. Relevant studies were identified, and related articles were separated. Google Scholar, as well as gray literature (i.e., information that is not produced by commercial publishers), were also checked for related articles to locate/identify additional studies. The relevant databases were searched a second time to ensure that recent studies were included. In conclusion, while curcumin, genistein, and resveratrol have demonstrated effectiveness in this regard, it should be emphasized that coumarins, quercetin, and other herbal medicines also have beneficial effects on transporter function, transmembrane conductivity, and overall channel activity. Additional in vitro and in vivo studies should be conducted on mutant CFTR to unequivocally define the mechanism by which phytochemicals alter transmembrane channel function/activity, since the results of the studies evaluated in this review have a high degree of heterogenicity and discrepancy. Finally, continued research be undertaken to clearly define the mechanism(s) of action and the therapeutic effects that therapeutic phytochemicals have on the symptoms observed in CF patients in an effort to reduce mortality and morbidity.

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Section: Herbal Medicinementioning

confidence: 99%

Section: Curcuminmentioning

confidence: 99%