The effect of n−3 fatty acids on coronary atherosclerosis: Results from SCIMO, an angiographic study, background and implications

Abstract

According to the model of "response to injury," the arterial endothelium is occasionally injured in hyperlipidemia, hypertension, diabetes mellitus and in other states known as risk factors. The ensuing inflammatory response is modulated by cytokines and growth factors, among them platelet-derived growth factor (PDGF), and monocyte chemoattractant protein-1 (MCP-1). In two independent studies, we demonstrated that mRNA levels for PDGF-A and -B and for MCP-1 are reduced after ingestion of n-3 fatty acids by human volunteers. This reduction persists after monocyte stimulation/differentiation by adherence. Moreover, the reduction is brought about only by dietary n-3 fatty acids and not by other classes of unsaturated fatty acids (n-6 or n-9). This appears to be one major mechanism of action of reduced progression/increased regression of established coronary artery disease by ingestion of 1.5 g/d n-3 fatty acids, as assessed by coronary angiography in a randomized placebo-controlled double-blind intervention study in 223 patients. The study was conducted according to "Good Clinical Practice," comprehensive rules regulating investigations with pharmaceutical compounds. Together, our investigations lend support to the importance of PDGF-A, PDGF-B, and MCP-1 in the pathogenesis of atherosclerosis, and the beneficial role of n-3 fatty acids therein.

Efectos De Los Ácidos Grasos Omega 3 en Terapia Cardiovascular

“…Existen numerosos estudios que avalan que el consumo de EPA y DHA ayudan en la prevención o tratamiento de una serie de patologías, sobre todo aquellas en las que la inflamación tiene un papel importante en su desarrollo (25,26,27,28).…”

“…El estudio sobre "prevención de Aterosclerosis Coronaria Mediante Intervención con Ácidos Grasos Omega-3 de Origen Marino" demostró una reducción del desarrollo de la aterosclerosis al administrar dosis bajas de AGPI-3 1,65 g/día (76).…”

Desarrollo De Un Alimento Funcional a Partir De Thunnus Albacares. ¿puede Su Consumo Aumentar El Aporte Diario De Omega 3 Y Mejorar La Salud Cardiovascular?

“…Existen numerosos estudios que avalan que el consumo de EPA y DHA ayudan en la prevención o tratamiento de una serie de patologías, sobre todo aquellas en las que la inflamación tiene un papel importante en su desarrollo (31,32,33,34).…”

The Acute Respiratory Distress Syndrome: Role of Nutritional Modulation of Inflammation Through Dietary Lipids

“…The results showed that patients fed EPA ϩ GLA had a significant reduction in BALF ceruloplasmin (a measure of alveolar membrane permeability) Vol. 19,No. 6 both groups.…”

“…19,No. 6 son, provision of diets containing long-chain PUFAs, such as EPA and GLA, that are metabolized regardless of existing alterations in ⌬-6 desaturase activity may prove beneficial to critically ill patients with ongoing inflammatory processes.…”