The Effect of Mydriatics Upon the Intraocular Pressure in So-Called Primary Wide-Angle Glaucoma*

Kronfeld, Peter C.; McGarry, H. Isabelle; Smith, Homer E.

doi:10.1016/s0002-9394(43)92828-4

Cited by 40 publications

(13 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…3,11 Valle noted an increase in aqueous inflow in patients who experienced a rise in IOP following dilation and in addition suggested a decrease in aqueous outflow in the same patients. 5 For many patients in his study, aqueous inflow decreased to a greater extent than aqueous outflow with a resultant fall in IOP.…”

Section: Discussionmentioning

confidence: 97%

See 1 more Smart Citation

Changes in intraocular pressure following diagnostic mydriasis with cyclopentolate 1%

Hancox

Murdoch

Parmar

2002

Eye

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 97%

“…11 In later studies Harris demonstrated that approximately two out of 100 patients with POAG had a significant rise in IOP following administration of cycloplegics.…”

Section: Discussionmentioning

confidence: 99%

Changes in intraocular pressure following diagnostic mydriasis with cyclopentolate 1%

Hancox

Murdoch

Parmar

2002

Eye

View full text Add to dashboard Cite

“…No further description is given of the conditions. Kronfeld et al (1943) studied the effects of homatropine and paredrine ( a sympathomimetic drug), as well as of a combination of these two mydriatics on the tension in 15 patients (18 eyes) with open-angle glaucoma. The combined drugs gave the highest rise.…”

mentioning

confidence: 99%

Pigment Liberation Test in Open‐angle Glaucoma

Kristensen

1968

Acta Ophthalmologica

View full text Add to dashboard Cite

In 1921 Koelner described a patient with simple glaucoma, whose intraocular pressure rose 10 mm Hg on dilatation of the pupil. This patient had abundant pigment on the posterior surface of the cornea and the anterior surface of the iris. In 12 other patients with simple glaucoma mydriasis provoked by atropine, homatropine, or scopolamine involved no rise in pressure. Vogt (1925), among 12 patients with pseudo-exfoliation of the anterior lens capsule, found two in whom dilatation of the pupil released an excessive liberation of pigment floating in the aqueous humour. These patients suffered from glaucoma. No mention is made of the tension in relation to the appearance of pigment granules.Various workers, e. g. Bard (1934) and Pillat (1934) have since reported on such floaters in the aqueous humour following mydriasis. Pillat, using a stop watch, measured the velocity of movement of the pigment granules in the aqueous humour of patients with glaucoma and pseudo-exfoliation. A distance of 1 cm was covered in 75 seconds.We now know that even in normals mydriasis is often followed by presence of floaters in the aqueous humour. This may be of importance in the differential diagnosis from iritis. The mydriasis-induced floaters differ, however, completely in kind from those occurring in genuine iritis. The former consist in the main of fine, brownish, sometimes glossy, bronze-coloured pigment granules, whercas the latter are larger and greyish. These consist predominantly of mononuclear cells.In patients with open-angIe glaucoma, with or without pseudo-exfolation, such a mydriasis-induced pigment liberation may be excessive and sometimes be accompanied by an acute, transistory rise in pressure. This is a factor which seems to have attracted little attention, being mentioned in none of a series of reports on the influence of mydriatics on glaucomatous eyes and normal eyes. Rentz ( 1924) described the effect of subconjunctival adrenalin injection 586

show abstract

“…Figures 3 and 4 present the individual behaviour of the corresponding pupil sizes. (Kronfeld, McGarry & Smith, 1943) showed a slight increase in IOP with homatropine and paredrine in 15 eyes of POAG patients. Since, barring case 3, the pupils of the eyes treated with GA dilated during the first few hours following administration.…”

Section: Resultsmentioning

confidence: 88%

Guanethidine ? adrenaline eye drops in glaucoma simplex

Hoyng¹,

Dake²

1981

Doc Ophthalmol

View full text Add to dashboard Cite

In the study reported here, the relation between the dilatation of the pupil and the course of intraocular pressure (IOP) is examined in open angle glaucoma patients and in glaucoma suspects after topical administration of the combination of guanethidine 3% and adrenaline 0.5% in one eye drop (GA). By treating one eye with GA and leaving the fellow eye untreated on the same day, there was a symmetrical response of IOP, independent of the mydriasis in the treated eyes. It leads to the conclusion that the mydriatic response has no influence on the course of IOP. The physiological explantation for the symmetrical course of IOP in both treated and untreated fellow eyes seems to be a mediation by the bloodstream of GA to the eye which was left untreated.

show abstract

The Effect of Mydriatics Upon the Intraocular Pressure in So-Called Primary Wide-Angle Glaucoma*

Cited by 40 publications

References 1 publication

Changes in intraocular pressure following diagnostic mydriasis with cyclopentolate 1%

Changes in intraocular pressure following diagnostic mydriasis with cyclopentolate 1%

Pigment Liberation Test in Open‐angle Glaucoma

Guanethidine ? adrenaline eye drops in glaucoma simplex

Contact Info

Product

Resources

About