The effect of mutation in the gene of cationic trypsinogen PRSS1 on the severity of acute pancreatitis

Abstract

necrosectomy, and 16 patients required surgery of which 15 were being managed with PCD. Overall Sepsis reversal with PCD was seen in 55.3% patients. Curative efficacy of PCD was 46.4%. Patients referred within one week of PCD placement had better survival (20.8% vs. 54.8%, P=0.011), higher sepsis reversal with PCD (75% vs. 42%, P=0.014) and lower surgical mortality (16.6% vs. 77.7%) as compared to patients referred after one week of PCD insertion. Conclusions: In the step-up era, there has been change in referral pattern in acute pancreatitis with patients being referred in the later part of the disease process. In this study, early referral to the surgical unit with respect to PCD placement has shown better outcomes.