Nurses caring for patients with acute stroke are likely to administer both music and medication with therapeutic intent. The administration of medication is based on accumulated scientific evidence and tailored to the needs of each patient. However, the therapeutic use of music is generally based on good intentions and anecdotal evidence. This review summarizes and examines the current literature regarding the effectiveness of music in the treatment of critically ill patients and the use of music in neurologically injured patients. The rationale for hypothesis-driven research to explore therapeutic music intervention in acute stroke is compelling. (Critical Care Nurse. 2016;36[2]:e1-e7) "Music hath charms to soothe the savage breast." W. Congreve, The Mourning Bride M usic has long been used in health care for its healing powers and has given rise to the practice of music therapy. The American Music Therapy Association defines music therapy as the "clinical and evidence-based use of music interventions to accomplish individualized goals within a therapeutic relationship by a credentialed professional who has completed an approved music therapy program."1 Board-certified music therapists employ customized music therapy interventions based on the best evidence from published literature, their training and expertise, and the needs of the patient.1 Music therapy is powerful, physically noninvasive, and can mediate positive outcomes when