The effect of multistrain synbiotic and vitamin D3 supplements on the severity of atopic dermatitis among infants under 1 year of age: a double-blind, randomized clinical trial study

Aldaghi, Mitra; Tehrani, Human; Karrabi, Maryam; Abadi, Fatemeh Sham; Sahebkar, Mohammad

doi:10.1080/09546634.2020.1782319

Cited by 13 publications

(28 citation statements)

References 22 publications

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“…A similar double-blind study was conducted by Aldaghi et al on AD infants that were administered either a synbiotic mix containing L. rhamnosus , L. euteri and B. infantis or vitamin D3. The report confirmed both treatments significantly decreased SCORAD scores when compared to the control group [ 111 ].…”

Section: Probiotics and Prebiotics In Treatment Of Atopic Dermatitismentioning

confidence: 78%

Skin Microbiota in Atopic Dermatitis

Hrestak

Matijašić

Paljetak

et al. 2022

IJMS

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The skin microbiota represents an ecosystem composed of numerous microbial species interacting with each other, as well as with host epithelial and immune cells. The microbiota provides health benefits to the host by supporting essential functions of the skin and inhibiting colonization with pathogens. However, the disturbance of the microbial balance can result in dysbiosis and promote skin diseases, such as atopic dermatitis (AD). This review provides a current overview of the skin microbiota involvement in AD and its complex interplay with host immune response mechanisms, as well as novel therapeutic strategies for treating AD focused on restoring skin microbial homeostasis.

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Section: Probiotics and Prebiotics In Treatment Of Atopic Dermatitismentioning

confidence: 78%

Skin Microbiota in Atopic Dermatitis

Hrestak

Matijašić

Paljetak

et al. 2022

IJMS

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“…The main search resulted in 2063 studies potentially relevant for inclusion ( Figure 1 ); of these, 32 studies 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 (8400 unique participants) met our criteria and were included in this systematic review ( Table 1 ). A subgroup of 21 studies 8 , 9 , 10 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 (7358 unique participants) were eligible for meta-analysis because they included a control group receiving either low-dose vitamin D supplementation (≤400 IU/d) or placebo.…”

Section: Resultsmentioning

confidence: 99%

“…Daily oral high-dose vitamin D intervention ranged from 1200 to 10 000 IU/d, whereas bolus doses ranged from 30 000 IU/week to 600 000 IU as a single dose. Twenty-five of the 32 RCTs 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 26 , 28 , 32 , 33 , 34 , 35 , 36 , 37 had 2 intervention groups, whereas the remaining 7 studies 25 , 27 , 29 , 30 , 31 , 38 , 39 compared more than 2 groups. Only 1 study 11 used 6 years as the upper age limit in their eligibility criteria.…”

Section: Resultsmentioning

confidence: 99%

“…Only 1 study 11 used 6 years as the upper age limit in their eligibility criteria. Fifteen studies 16 , 20 , 21 , 23 , 25 , 26 , 28 , 30 , 31 , 32 , 34 , 35 , 36 , 37 , 39 included infants (aged 0-12 months) as their only eligible age group, when they were included. In 9 studies, 8 , 9 , 11 , 12 , 13 , 14 , 15 , 16 , 17 at least 1 intervention group received a bolus dose of greater than 100 000 IU.…”

Section: Resultsmentioning

confidence: 99%

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Safety of High-Dose Vitamin D Supplementation Among Children Aged 0 to 6 Years

et al. 2022

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Key Points Question Is high-dose vitamin D supplementation safe for children aged 0 to 6 years? Findings In this systematic review and meta-analysis of 32 randomized clinical trials including 8400 unique children, high-dose vitamin D administered as a daily or bolus supplement was not associated with an increased risk of serious adverse events. Clinical adverse events associated with the supplementation were rare. Meaning This systematic review and meta-analysis suggests that vitamin D supplements in daily doses to 10 000 IU/d or bolus doses to 600 000 IU are well tolerated in children aged 0 to 6 years.

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“…The vitamin D3 group received 1,000 units (IU) of vitamin D3 daily, aside from the routine treatment. According to the results, an effective way to reduce the severity of AD in infants is represented by multistrain synbiotics, alongside vitamin D3 supplements and routine treatments ( 59 ).…”

Section: Controversiesmentioning

confidence: 99%

Probiotics and prebiotics in atopic dermatitis: Pros and cons (Review)

Fanfaret

Boda

Ion³

et al. 2021

Exp Ther Med

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Atopic dermatitis (AD) represents a chronic inflammatory skin condition in which the skin barrier is impaired; thus, the permeability is increased. Hence, there is a greater risk of allergic sensitization, as well as a higher pH and lower protection against resident microbes. Since this condition is currently increasing among children, it requires further study, as little is known regarding the pathogenesis that makes the skin prone to chronic relapsing inflammation. Trying to standardize the data regarding the use of prebiotics and probiotics in AD, we encountered tremendous variability in the literature data. Literature abounds in conflicting data: studies regarding prophylactic and therapeutic applications, different types of strains and dosages, applications in young children up to 5 years of age and above, usage of probiotics alone, prebiotics alone or synbiotics combined. There are also conflicting data regarding the outcome of these studies; some confirming a positive effect of prebiotics, probiotics or synbiotics and some showing no efficacy at all. The articles were divided into those assessing probiotics or prebiotics alone and a combination of the two, with studies showing a positive effect and studies proving no efficacy at all. We tried to critically analyze those articles showing weak and strong points. In summary, the most studied probiotics were the strains of Lactobacilli and Bifidobacteria . The Severity Scoring of Atopic Dermatitis (SCORAD) index was used to measure the efficacy of the treatment. Most studies compared their results with a placebo group and the efficacy when seen in moderate to severe forms of AD in patients with other allergic diseases present. However, the results are difficult to interpret, as in many studies the authors suggest that the disease may have a tendency to improve in time in some groups of patients.

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The effect of multistrain synbiotic and vitamin D3 supplements on the severity of atopic dermatitis among infants under 1 year of age: a double-blind, randomized clinical trial study

Cited by 13 publications

References 22 publications

Skin Microbiota in Atopic Dermatitis

Skin Microbiota in Atopic Dermatitis

Safety of High-Dose Vitamin D Supplementation Among Children Aged 0 to 6 Years

Probiotics and prebiotics in atopic dermatitis: Pros and cons (Review)

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