The effect of multiple primary rules on population-based cancer survival

Weir, Hannah K.; Johnson, Christopher; Thompson, Trevor

doi:10.1007/s10552-013-0203-3

Cited by 76 publications

(62 citation statements)

References 13 publications

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“…18 Weir et al found an incidence of multiple primaries of 19.7% following the SEER guidelines (or 16.9% IACR rules) in colon and 21% (SEER; 19.9% IACR) in patients with lung cancer. 6 Amer et al found similar incidences of multiple primaries in patients with colon cancer; however, they only reported 5.6% multiple primaries in patients with lung cancer. 11 Long-term survival with multiple primaries is variable and is influenced by cancer type and stage at diagnosis.…”

Section: Epidemiology Of Multiple Primariesmentioning

confidence: 92%

“…3 In epidemiological studies, the frequency of multiple primaries is reported to be in the range of 2-17%. [4][5][6][7][8] Many factors can influence the reported numbers of multiple primaries, namely the definition that was applied (see below), the follow-up time since the longer patients are followed up after a primary cancer diagnosis, the higher the likelihood that they may develop a second malignancy and importantly also the patient population studied. 9 Today, the situation of patients with multiple primaries is of increasing relevance and importance.…”

Section: Introductionmentioning

confidence: 99%

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Multiple primary tumours: challenges and approaches, a review

et al. 2017

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When in a patient more than one tumour in the same or a different organ is diagnosed, multiple primary tumours may be present. For epidemiological studies, different definitions of multiple primaries are used with the two main definitions coming from the project Surveillance Epidemiology and End Results and the International Association of Cancer Registries and International Agency for Research on Cancer. The differences in the two definitions have to be taken into consideration when reports on multiple primaries are analysed. In this review, the literature on multiple primaries is reviewed and summarised. Overall, the frequency of multiple primaries is reported in the range of 2–17%.Aetiological factors that may predispose patients to multiple primaries can be grouped into host related, lifestyle factors and environmental influences. Some of the most common cancer predisposition syndromes based on a clinical presentation are discussed and the relevant genetic evaluation and testing are characterised.Importantly, from a clinical standpoint, clinical situations when multiple primaries should be suspected and ruled out in a patient are discussed.Furthermore, general principles and possible treatment strategies for patients with synchronous and metachronous multiple primary tumours are highlighted.

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Section: Epidemiology Of Multiple Primariesmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Multiple primary tumours: challenges and approaches, a review

et al. 2017

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“…An important but overlooked fact is the multifocality of cancer, with a surprisingly high frequency of multiple lesions of primary origin (with estimates ranging between 3% and 25%) of same or different histological types, with concomitant or subsequent occurrence (synchronous versus metachronous lesions), and with occurrences at proximal versus distant organ sites (7)(8)(9)). An obvious difficulty is distinguishing between truly independent primary lesions and separate lesions that are the result of distant spread with single initiating events.…”

Section: The Clinical Problemmentioning

confidence: 99%

Multifocal epithelial tumors and field cancerization: stroma as a primary determinant

Dotto¹

2014

J. Clin. Invest.

127

112

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It is increasingly evident that cancer results from altered organ homeostasis rather than from deregulated control of single cells or groups of cells. This applies especially to epithelial cancer, the most common form of human solid tumors and a major cause of cancer lethality. In the vast majority of cases, in situ epithelial cancer lesions do not progress into malignancy, even if they harbor many of the genetic changes found in invasive and metastatic tumors. While changes in tumor stroma are frequently viewed as secondary to changes in the epithelium, recent evidence indicates that they can play a primary role in both cancer progression and initiation. These processes may explain the phenomenon of field cancerization, i.e., the occurrence of multifocal and recurrent epithelial tumors that are preceded by and associated with widespread changes of surrounding tissue or organ "fields."

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“…The incidence of second primary malignancy varies greatly in different cancer sites, ranging from 2% to 17% 1. Lung cancer is, by far, at the highest risk of developing second primary, accounting for 21% and 19.9% as reported by the Surveillance Epidemiology and End Results (SEER) and the International Association of Cancer Registries (IACR), respectively 2. Here we report the case of a patient who was diagnosed with stage IV non-small cell lung cancer, developed a second primary in his colon after 3 years and remained stable with more than 5 years of follow-up.…”

Section: Introductionmentioning

confidence: 99%

Prolonged survival with maintenance pemetrexed for a multiple primary malignancy

Shuayb

Salehi

2018

BMJ Support Palliat Care

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Despite the fact that multiple primary malignancies (MPMs) are not new and have been diagnosed for about a hundred-year time, literatures on lung and colon primaries are scarce. We report a case of a 62-year-old Asian Bangladeshi man with stage IV lung adenocarcinoma who developed a metachronous stage II colon adenocarcinoma approximately 3 years later. A chemotherapy protocol of six cycles of pemetrexed/cisplatin followed by maintenance pemetrexed was used, and surgery was done for the colon primary. With more than 5 years of periodic follow-up, his disease remains stable without any local or metastatic recurrence. Definitive therapeutic protocols are unavailable, but information taken with caution from case reports may be of importance for treatment decisions of MPMs. We believe that management with careful judgement by a multidisciplinary team may result in a good outcome with longer survival.

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The effect of multiple primary rules on population-based cancer survival

Cited by 76 publications

References 13 publications

Multiple primary tumours: challenges and approaches, a review

Multiple primary tumours: challenges and approaches, a review

Multifocal epithelial tumors and field cancerization: stroma as a primary determinant

Prolonged survival with maintenance pemetrexed for a multiple primary malignancy

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