The effect of multiple-dose ivermectin treatment on CD4+/CD8+ and the oxidative stress index in goats with udder viral papillomatosis

Bozkurt, Gökhan; Kaya, Feyyaz; Yıldırım, Yakup; Yıldız, Ramazan; Gungo, Orsan; Doğan, Fırat; Ayozger, Leyla Elif Ozgu

doi:10.1016/j.rvsc.2023.02.006

Cited by 1 publication

(1 citation statement)

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“…ChPV can cause persistent host infections, posing a threat to the goat industry. Therefore, new experimental therapeutic protocols against ChPV infections are being developed ( 20 ).…”

Section: Discussionmentioning

confidence: 99%

Prevalence and genotype distribution of caprine papillomavirus in peripheral blood of healthy goats in farms from three European countries

et al. 2023

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Caprine papillomaviruses (ChPVs, Capra hircus papillomaviruses) were detected and quantified for the first time using droplet digital polymerase chain reaction (ddPCR) in blood samples of 374 clinically healthy goats from farms located in Italy, Romania, and Serbia. Overall, ddPCR revealed ChPV DNA in 78 of the 374 examined samples, indicating that ~21% of the goats harbored circulating papillomavirus DNA. In particular, in Italian goat farms, ChPV genotypes were detected and quantified in 58 of 157 blood samples (~37%), 11 of 117 samples from Serbian farms (~9.4%), and 9 of 100 from Romanian blood samples (9%). Blood samples from Italian goat farms showed a high prevalence of ChPV1, which was detected in 45 samples (28.6%). The ChPV2 genotype was detected in 13 samples (~8.3%). Therefore, significant differences in prevalence and genotype distributions were observed. On Serbian and Romanian farms, no significant differences were observed in the genotype prevalence of ChPVs. Molecular findings are consistent with ChPV prevalence, characterized by a territorial distribution similar to that of papillomaviruses in other mammalian species. Furthermore, this study showed that ddPCR is a very sensitive and accurate assay for ChPV detection and quantification. The ddPCR may be the molecular diagnostic tool of choice, ultimately providing useful insights into the molecular epidemiology and field surveillance of ChPV.

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“…ChPV can cause persistent host infections, posing a threat to the goat industry. Therefore, new experimental therapeutic protocols against ChPV infections are being developed ( 20 ).…”

Section: Discussionmentioning

confidence: 99%