The effect of mouthwashes containing biguanides on the progression of erosion in dentin

Charone, Senda; Cardoso, Cristiane de Almeida Baldini; Kato, Melissa Thiemi; Ducati, Paula; Fukushima, Rejane; Gennaro, Gabriela; Magalhães, Ana Carolina; Buzalaf, Marília Afonso Rabelo

doi:10.1186/1472-6831-14-131

Cited by 9 publications

(9 citation statements)

References 53 publications

(69 reference statements)

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“…Calcium phosphate-based agents can supply calcium or phosphate ions that are lost from the tooth surface in acidic conditions [ 36 , 71 , 109 , 110 , 111 ]. Some agents can inhibit MMPs, preserve the demineralised organic matrix of the dentine structure and hamper acid diffusion [ 83 , 141 , 152 , 154 , 159 , 160 ]. The properties of each anti-erosive agent are shown in Table 2 .…”

Section: Discussionmentioning

confidence: 99%

“…CHX is used in controlling dental erosion because it is an inhibitor of MMPs [ 141 , 159 , 160 ]. It inhibits collagen degradation by inhibiting MMPs 2, 8 and 9 in acidic attacks [ 141 , 159 ].…”

Section: Anti-erosive Agents In the Literaturementioning

confidence: 99%

“…CHX reduced the surface loss and hardness change in dentine specimens after erosive challenges in in situ settings [ 159 , 160 , 161 ]. CHX should not be used with fluoride in controlling dental erosion because it has an antagonistic effect with fluoride [ 161 ].…”

Section: Anti-erosive Agents In the Literaturementioning

confidence: 99%

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Topical Agents for Nonrestorative Management of Dental Erosion: A Narrative Review

Chawhuaveang

Yin

et al. 2022

Healthcare

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A nonrestorative approach to the management of dental erosion is the foremost option: controlling dental erosion. The objectives of this study are to provide an overview and to summarise the effects and properties of topical anti-erosive agents as a nonrestorative treatment of dental erosion. A literature search was conducted on five databases of peer-reviewed literature—Cochrane Library, EMBASE, PubMed, Scopus and Web of Science—to recruit articles published between 1 January 2000 and 31 December 2021. The literature search identified 812 studies; 95 studies were included. Topical anti-erosive agents can be broadly categorised as fluorides, calcium phosphate-based agents, organic compounds and other anti-erosive agents. In the presence of saliva, fluorides promote the formation of fluorapatite on teeth through remineralisation. Calcium phosphate-based agents supply the necessary minerals that are lost due to the acid challenge of erosion. Some organic compounds and other anti-erosive agents prevent or control dental erosion by forming a protective layer on the tooth surface, by modifying salivary pellicle or by inhibiting the proteolytic activity of dentine collagenases. Topical anti-erosive agents are promising in managing dental erosion. However, current evidence shows inconsistent or limited results for supporting the use of these agents in clinical settings.

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Section: Discussionmentioning

confidence: 99%

Section: Anti-erosive Agents In the Literaturementioning

confidence: 99%

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Topical Agents for Nonrestorative Management of Dental Erosion: A Narrative Review

Chawhuaveang

Yin

et al. 2022

Healthcare

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“…[ 34 ] It has found several antimicrobial applications in medicine, dentistry, and environmental sciences. [ 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 ] However, its utility in endodontic disinfection has seldom been explored. This study compared the substantivity of two biguanides-CHX and PHMB.…”

Section: Discussionmentioning

confidence: 99%

Comparative evaluation of substantivity of two biguanides - 0.2% polyhexanide and 2% chlorhexidine on human dentin

Chandki

Nikhil

Kalyan³

2020

J Conserv Dent

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Background: Substantivity is one of the desirable characteristics of root canal irrigants. Among conventional endodontic irrigants, only chlorhexidine (CHX) is known to exert significant substantivity on root canal dentin. This study explored the substantivity activity of a polymeric biguanide-poly hexamethylene biguanide (PHMB). Aim: The aim of this study was to determine the substantivity of a polymeric biguanide - 0.2% PHMB and compare it with that of 2% CHX. Materials and Methods: To evaluate and compare the substantivity of 0.2% PHMB and 2% CHX on root canal dentin, dentin disks were prepared and substantivity after 1 h, 24 h, 7 days and 21 days was measured using spectrophotometry. Statistical Analysis Used: The data so obtained were analyzed, and the intergroup comparison was made using unpaired t -test. Results: The results of this study indicated that 0.2%. PHMB exerts significantly greater substantivity than 2% CHX on human dentin. Conclusion: Within the limitations, this study supports the use of 0.2% polyhexanide as an endodontic irrigant based on its property of substantivity.

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“…3 When enamel loss occurs, the effects of acids further extend into the dentin, and dentin erosion can occur. 3 , 4 During the progression of dentin erosion, minerals are released from the peritubular and intertubular dentin. 5 Thereafter, a layer of a fully demineralized organic matrix (DOM) is formed in the superficial dentin, followed by a partially demineralized zone and by the intact inner dentin.…”

Section: Introductionmentioning

confidence: 99%

Do matrix metalloproteinase and cathepsin K inhibitors work synergistically to reduce dentin erosion?

et al. 2023

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Objectives To evaluate the effects of matrix metalloproteinase (MMP) and cathepsin K (catK) inhibitors on resistance to dentin erosion. Methodology A total of 96 dentin specimens (3×3×2 mm) were prepared and randomly assigned into four groups (n=24): deionized water (DW); 1 µM odanacatib (ODN, catK inhibitor); 1 mM 1,10-phenanthroline (PHEN, MMP inhibitor); and 1 µM odanacatib + 1 mM 1,10-phenanthroline (COM). Each group was further divided into two subgroups for the application of treatment solutions before (PRE) and after erosive challenges (POST). All specimens were subjected to four daily erosive challenges for 5 d. For each erosive challenge, the specimens in subgroup PRE were immersed in the respective solutions before cola drinks, while the specimens in subgroup POST were immersed in the respective solutions after cola drinks (the immersion duration was 5 min in both cases). All specimens were stored in artificial saliva at 37°C between erosive challenges. The erosive dentin loss (EDL) was measured by profilometry. The residual demineralized organic matrix (DOM) of specimens was removed using type VII collagenase and evaluated by profilometry. Both the EDL and thickness of the residual DOM were statistically analyzed by two-way analysis of variance (ANOVA) and Bonferroni’s test (α=0.05). The surface topography and transverse sections of the specimens were observed using SEM. MMPs and catK were immunolabeled in the eroded dentin and in situ zymography was performed to evaluate the enzyme activity. Results Significantly lower EDL was found in the groups ODN, PHEN, and COM than in the control group (all p<0.05), while no significant difference in EDL was found among the groups ODN, PHEN, and COM (all p>0.05). The application sequence showed no significant effect on the EDL of the tested groups (p=0.310). A significantly thicker DOM was observed in the group ODN than in the control group regardless of the application sequence (both p<0.05). The treatment with ODN, PHEN, and COM inhibited the gelatinolytic activity by approximately 46.32%, 58.6%, and 74.56%, respectively. Conclusions The inhibition of endogenous dentinal MMPs and catK increases the acid resistance of human dentin but without an apparent synergistic effect. The inhibition of MMPs and catK is equally effective either before or after the acid challenge.

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The effect of mouthwashes containing biguanides on the progression of erosion in dentin

Cited by 9 publications

References 53 publications

Topical Agents for Nonrestorative Management of Dental Erosion: A Narrative Review

Topical Agents for Nonrestorative Management of Dental Erosion: A Narrative Review

Comparative evaluation of substantivity of two biguanides - 0.2% polyhexanide and 2% chlorhexidine on human dentin

Do matrix metalloproteinase and cathepsin K inhibitors work synergistically to reduce dentin erosion?

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