The effect of mouthrinses on severe acute respiratory syndrome coronavirus 2 viral load

Silva, António; Azevedo, Maria João; Sousa‐Pinto, Bernardo

doi:10.1016/j.adaj.2021.12.007

Cited by 15 publications

(10 citation statements)

References 61 publications

(87 reference statements)

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“…The COVID‐19 pandemic prompted a dramatic closure or limitation of dental services worldwide, thus causing serious health and economic consequences (Marcenes, 2020 ). The increasing risks in SARS‐CoV‐2 transmission via saliva and respiratory secretions during dental procedures has led to the use of pre‐operating mouthwashes (Tadakamadla et al, 2021 ; Mendoza et al, 2022 ; Silva et al, 2021 ) as additional preventive measures together with physical barriers such as facial masks and facial barriers.…”

Section: Introductionmentioning

confidence: 99%

“…The COVID-19 pandemic prompted a dramatic closure or limitation of dental services worldwide, thus causing serious health and economic consequences (Marcenes, 2020). The increasing risks in SARS-CoV-2 transmission via saliva and respiratory secretions during dental procedures has led to the use of pre-operating mouthwashes (Tadakamadla et al, 2021;Mendoza et al, 2022;Silva et al, 2021) as additional preventive measures together with physical barriers such as facial masks and facial barriers. SARS-CoV-2 is surrounded by a lipid envelope that includes spike (S) glycoproteins able to interact with cell receptors widely expressed in mucosal tissues, gingiva, tongue, and salivary glands (Carrouel et al, 2021;Hamming et al, 2004).…”

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confidence: 99%

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In vitro virucidal activity of mouthwashes on SARS‐CoV‐2

et al. 2022

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Objectives The objective of the study was to evaluate the in vitro virucidal activity of commercial mouthwashes against SARS‐CoV‐2 and variants of concern. Materials and Methods Antiviral activity was assessed at different time intervals, based on common use of these products by titrating residual viral infectivity on Vero E6 cells. Results All the mouthwashes were effective to reduce the infectious titers of SARS‐CoV‐2 and its tested variants. Mouthwashes Listerine ® Cool Mint milder taste and Listerine ® Cavity Protection milder taste reduced the infectious viral titer by up to 3.9 log10 after 30 s, while mouthwash Cetilsan ® Sugar Free was able to reduce the viral titer by 2.2–2.9 log10 at all tested time intervals. Mouthwash Curasept ® ADS DNA Intensive treatment was less effective to decrease viral infectivity (0.7–2.2 log10 TCID50/ml at all tested time intervals). Interestingly, the Gamma variant appeared more resistant to treatment in vitro with the different mouthwashes. Conclusions In this study, we were able to assess the ability of different mouthwashes to in vitro decrease the infectivity of SARS‐CoV‐2 and its variants, and we observed that Gamma variant of concern was more resistant to treatment with mouthwashes.

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Section: Introductionmentioning

confidence: 99%

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confidence: 99%

In vitro virucidal activity of mouthwashes on SARS‐CoV‐2

et al. 2022

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“…The use of pre-procedural mouth rinses should be considered routine in clinical dental practice because it could prevent the spread of the virus by reducing the number of microorganisms released from patient's saliva during splatter [14]. In clinical trials, povidone-iodine-based mouth rinses appeared to be the most effective oral pre-procedural mouth rinse in the context for SARS-CoV-2 viral load reduction [15].…”

Section: Safety Precaution and Infection Control Practices Among Dent...mentioning

confidence: 99%

Safety Precaution and Infection Control Practices among Dental Practitioners in Nigeria during the COVID-19 Pandemic

Menakaya

Menakaya²,

Abah

et al. 2023

EJDENT

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Background: COVID-19 remains a major public health threat globally and dental practitioners are particularly at risk due to the proximity of care givers to the patient and the generation of aerosols during many dental treatment procedures. Dental practitioners are therefore required to strictly observe standard universal precautions in their clinical practice. Objectives: To determine the safety precaution and infection control practices among dental practitioners in Nigeria during the COVID-19 Pandemic. Methods: A cross-sectional self-administered pre-tested questionnaire based survey of consenting dental practitioners from different geopolitical zones in Nigeria was employed for the study. Study participants were recruited by non-random convenience sampling. Data were analyzed using Statistical Package for Social Sciences (SPSS) version 20. Results: A total of 105 out of 142 respondents completed and returned the survey questionnaire giving a response rate of 74%. About 24-55% of study respondents performed aerosol/splatter/droplet generating procedures. Hand hygiene and donning of face mask were the most common safety practices while the use of face shield and N95 facemask were common infection control practices. Over 60% of respondents practiced triaging of patients, pre-procedural mouth rinse and donning of disposable surgical gowns. Almost half of the respondents practiced decontamination of the clinic work environment and over 70% of respondents used N95 masks. Conclusion: Aerosol generating procedures were not uncommon dental practices in Nigeria during COVID-19 pandemic. However, use of N95 mask was relatively high and there was a reasonable level of practice of basic standard COVID-19 safety measures and infection prevention and control guidelines.

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“…A systematic review in 2022 evaluated several types of mouthwash [ 55 ] and concluded that, after a povidone-iodine solution, CPC is the most effective in vitro and in vivo to reduce the viral load of SARS-CoV-2 in saliva. CPC has a substantivity of 2–5 h [ 56 ]. In vivo, research demonstrates that the viral pressure of the SARS-CoV-2 virus in the saliva is suppressed for up to 3–6 h after rinsing with CPC [ 57 , 58 ].…”

Section: Introductionmentioning

confidence: 99%

Aerosol in the oral health-care setting: a misty topic

Weijden

2023

Clin Oral Invest

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Studies have shown that mouth and respiratory tract microorganisms can be transported in aerosol and spatter. Due to aerosol-generating procedures, there are potentially various infection risks for patients and those working in health care, especially in oral health care. Dental aerosol can contaminate not only the mucous membranes of the oral health-care professional’s mouth, respiratory passages, and eyes but also exposed surfaces and materials in the environment. As such, preventing disease transmission within oral health-care offices is important issue. Since the start of the COVID-19 pandemic, an innumerable amount of (mis)information and advice on how to stay safe and prevent the spread of coronavirus has been published. What preventive measures can and have been taken to counteract this, and what have we learned during the pandemic? This review summarizes relevant literature that has addressed the presence and dispersal of aerosol and spatter as a concern in health care. It includes the sources of dental aerosol, their potential health threats, and strategies for controlling and mitigating their impact. It shows that further research is needed to better understand the potential health risks of dental aerosol and to develop effective strategies for mitigating them. Clinical relevance Using personal protective equipment, high-volume evacuation systems and pre-procedural antimicrobial agents can help to reduce the potential for infection in oral health-care settings and protect the well-being of oral health-care workers and their patients.

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The effect of mouthrinses on severe acute respiratory syndrome coronavirus 2 viral load

Cited by 15 publications

References 61 publications

In vitro virucidal activity of mouthwashes on SARS‐CoV‐2

In vitro virucidal activity of mouthwashes on SARS‐CoV‐2

Safety Precaution and Infection Control Practices among Dental Practitioners in Nigeria during the COVID-19 Pandemic

Aerosol in the oral health-care setting: a misty topic

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