The effect of Moringa oleifera leaf extracts against urethane-induced lung cancer in rat model

Ibrahim, Mona Abdel Rahman; Mohamed, Saleh A.; Dkhil, Mohamed A.; Thagfan, Felwa A.; Abdel‐Gaber, Rewaida; Soliman, Doaa

doi:10.1007/s11356-022-24813-9

Cited by 4 publications

(3 citation statements)

References 66 publications

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“…Studies of M. oleifera leaf extracts in rats with a urethane model of lung cancer showed improved induced changes in the concentrations of glutathione, superoxide dismutase and malondialdehyde. Compared with the control group, rats treated with the extract showed a moderate amount of collagen fibers and tumor atrophy and approximately restored normal lung histology (Ibrahim et al, 2023).…”

Section: Anticancer Activitymentioning

confidence: 89%

Moringa oleifera (drumstick tree)—nutraceutical, cosmetological and medicinal importance: a review

Klimek-Szczykutowicz,

Gaweł-Bęben,

Rutka

et al. 2024

Front. Pharmacol.

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Moringa oleifera Lam. (Moringaceae) is a species of tree with an increasing utility, occurring naturally mainly in Pakistan and northern India. M. oleifera is currently cultivated in Africa, South America, Asia and the Middle East. The usage of its leaves, seed oil, bark, fruits, flowers and roots has positive opinions of FDA (American Food and Drug Administration), EFSA (European Food Safety Authority) and CosIng (Cosmetic Ingredients database). The chemical composition of M. oleifera is dominated by: proteins (consisting mainly of amino acids such as arginine or serine), fatty acids (omega-3 and omega-6), vitamins (vitamin A, B and C and tocopherols), mineral salts (including several bioelements, such as calcium, magnesium, sodium, and potassium), valuable polyphenolic compounds from the group of phenolic acids (e.g., gallic acid, ferulic acid) and flavonoids (e.g., myricetin, rutoside, and kaempferol). The raw materials show antioxidant, hepatoprotective, anti-inflammatory and antimicrobial properties. Dietary supplements and alimentary products containing M. oleifera are recommended as health-promoting and “novel food” preparations. The main purpose of this work was a review of the latest scientific literature on M. oleifera, with particular emphasis on the studies focusing on its chemical composition, biological activity and safety. Moreover, the review tends to discuss the results of biotechnological studies using this material and the agronomical significance.

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Section: Anticancer Activitymentioning

confidence: 89%

Moringa oleifera (drumstick tree)—nutraceutical, cosmetological and medicinal importance: a review

Klimek-Szczykutowicz,

Gaweł-Bęben,

Rutka

et al. 2024

Front. Pharmacol.

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“…The leaf extract of M. oleifera contained 4-hydroxyphenylacetonitrile (92), lutein (93), adenosine (94), uridine ( 95…”

Section: Other Compoundsmentioning

confidence: 99%

“…The leaf extract of M. oleifera contained 4-hydroxyphenylacetonitrile (92), lutein (93), adenosine (94), uridine (95), 3-pyridinecarboxamide (96), 5-hydroxymethyl-2-furaldehyde (97), 5-hydroxymethyl-2-furancarboxylic acid (98), bis-isothiocyanatomethyl benzene ( 99 Compound 104 displayed a potent inhibition of CYP3A4, with an IC 50 value of 41.5 µg/mL, while compound 105 exhibited CYP3A4 inhibition with an IC 50 value of 100 µg/mL. Compound 107 also demonstrated CYP3A4 inhibitory activity, with an IC 50 value of 72.5 µg/mL.…”

Section: Other Compoundsmentioning

confidence: 99%

Moringa oleifera: A Review of the Pharmacology, Chemical Constituents, and Application for Dental Health

Amin,

Ariwibowo,

Putri

et al. 2024

Pharmaceuticals

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Moringa oleifera L., commonly known as Kelor in Indonesia and miracle tree in English, has a rich history of utilization for medicinal, nutritional, and water treatment purposes dating back to ancient times. The plant is renowned for its abundance of vitamins, minerals, and various chemical constituents, making it a valuable resource. Among its notable pharmacological properties are its effectiveness as an anti-diabetic, anti-diarrheal, anti-helmintic, anti-leishmanial, anti-fungal, anti-bacterial, anti-allergic, anti-cancer, anti-inflammatory, and anti-oxidant agent. In this comprehensive review, we delve into the extensive pharmacological applications and phytochemical constituents of M. oleifera and its application in dental health.

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Myrtenol ameliorates inflammatory, oxidative, apoptotic, and hyperplasic effects of urethane-induced atypical adenomatous hyperplasia in the rat lung

Amiresmaili,

Rajizadeh,

Jafari

et al. 2024

Naunyn-Schmiedeberg's Arch Pharmacol

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The effect of Moringa oleifera leaf extracts against urethane-induced lung cancer in rat model

Cited by 4 publications

References 66 publications

Moringa oleifera (drumstick tree)—nutraceutical, cosmetological and medicinal importance: a review

Moringa oleifera (drumstick tree)—nutraceutical, cosmetological and medicinal importance: a review

Moringa oleifera: A Review of the Pharmacology, Chemical Constituents, and Application for Dental Health

Myrtenol ameliorates inflammatory, oxidative, apoptotic, and hyperplasic effects of urethane-induced atypical adenomatous hyperplasia in the rat lung

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