The Effect of Monosodium Glutamate (Msg) Administration to Pyramidal Cells Necrosis on Cerebral Cortex of Wistar Male Rats (<i>Rattus Norvegicus</i>)

Fardian, Nur; Maulina, Meutia; Tabari, Mitra; Mardiati,

doi:10.1108/978-1-78756-793-1-00070

Cited by 3 publications

(3 citation statements)

References 7 publications

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“…This can be seen in the number of normal pyramid and purkinje neurons in the K+ group significantly decreased (p<0.05) compared to the K-group. These results are also in accordance with research conducted that MSG administration can significantly reduce the number of pyramidal cerebrum neurons and purkinje cerebellar neurons [14,15].…”

Section: Resultssupporting

confidence: 92%

Neuroprotective effects of Apis dorsata forest honey on the neurons count in cerebrum and cerebellum of mice (Mus musculus) exposed to monosodium glutamate

Suhud¹,

Widjiati²,

Rimayanti³

et al. 2023

World J. Adv. Res. Rev.

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Introduction: Monosodium glutamate or MSG can have an effect on increasing the production of reactive oxygen species (ROS) in the brain. Apis dorsata forest honey is known to have higher antioxidant activity than Apis mellifera and Apis cerana honey. This study aims to determine the preventive effect of Apis dorsata honey on the number of pyramidal cerebrum neurons and purkinje cerebellum neurons of mice (Mus musculus) exposed to monosodium glutamate (MSG). Material and Methods: This study used 25 mice which were divided into 5 groups. In the K- group only aquadest was given. The K+ group was given 4mg/gBB of MSG. Groups P1, P2, and P3 given Apis dorsata honey at a dose of 53.82mg/20gBW, 107.64mg/20gBW, and 161.46mg/20gBW. All treatments were carried out orally for 52 days. Results: The results showed that the average number of cerebral pyramidal neurons in the K-, K+, P1, P2, and P3 groups was 12.24±0.607; 7.24±2.875; 12.48±1.513; 15.72±0.944; and 19.28±2.827. The mean number of purkinje cerebellar neurons was 4.8±1.456; 2.08±0.807; 3.08±1.035; 3.56±0.434; and 4.68±1.390. Discussion: The average number of pyramidal neurons and purkinje neurons in the group given preventive dose of Apis dorsata honey and exposed to MSG was higher and there is a significant difference compared to the group that was only exposed to MSG. It can be concluded that the administration of Apis dorsata honey can maintain the number of pyramidal cerebrum neurons and purkinje cerebellar neurons in mice exposed to MSG.

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Section: Resultssupporting

confidence: 92%

Neuroprotective effects of Apis dorsata forest honey on the neurons count in cerebrum and cerebellum of mice (Mus musculus) exposed to monosodium glutamate

Suhud¹,

Widjiati²,

Rimayanti³

et al. 2023

World J. Adv. Res. Rev.

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“…It has also resulted in the impairment of non-spatial memory and learning of the animals and has contributed to an increase in calcium and sodium levels which may be attributed by the activation of NMDA receptors by MSG, causing ionic channels to open in an unregulated manner with excess entry of calcium and sodium ions ( Sama and Norris, 2013 ; Abdel Moneim et al, 2018 ). Histopathological finding also indicated some evidence of neuronal damage like cerebral edema and neuronal necrosis which is a clear indication of MSG-induced neurotoxicity ( Fardian et al, 2018 ).…”

Section: Discussionmentioning

confidence: 99%

Neuroprotective potential of Marsilea quadrifolia Linn against monosodium glutamate-induced excitotoxicity in rats

Subramanian,

Tamilanban,

Sekar

et al. 2023

Front. Pharmacol.

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“…According to Fardian et al, 57 increased glutamate concentration induced cell death in the pyramidal cells of the cerebral cortex through autophagy by lysosomes. The uncontrolled lysosome activity led to internal destruction and ended in neural necrosis.…”

Section: Discussionmentioning

confidence: 99%

Therapeutic role of adipose tissue–derived stem cells versus microvesicles in a rat model of cerebellar injury

Mazen

Abdel-Fattah

Desoky

et al. 2021

J Cellular Molecular Medi

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Monosodium glutamate (MSG) is a salt originally derived from herb and commonly marketed as a flavour enhancer. 1 It becomes extensively used in canned food, frozen entrees, crackers, processed meats and dietary supplements. It is also found in soaps, cosmetics, infant formula and vaccines. 2 MSG dissociates in solution to glutamate and sodium ions. 1 Glutamate is the foremost excitatory neurotransmitter in the body.Numerous transporters and receptors for glutamate are found in the

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The Effect of Monosodium Glutamate (Msg) Administration to Pyramidal Cells Necrosis on Cerebral Cortex of Wistar Male Rats (Rattus Norvegicus)

Cited by 3 publications

References 7 publications

Neuroprotective effects of Apis dorsata forest honey on the neurons count in cerebrum and cerebellum of mice (Mus musculus) exposed to monosodium glutamate

Neuroprotective effects of Apis dorsata forest honey on the neurons count in cerebrum and cerebellum of mice (Mus musculus) exposed to monosodium glutamate

Neuroprotective potential of Marsilea quadrifolia Linn against monosodium glutamate-induced excitotoxicity in rats

Therapeutic role of adipose tissue–derived stem cells versus microvesicles in a rat model of cerebellar injury

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