The effect of Mongolian medical acupuncture on cytokines and neurotransmitters in the brain tissue of insomniac rats

Si, Lengge; Wang, Yuehong; Wuyun, Gerile; Agula, B

doi:10.1016/j.eujim.2015.05.008

Cited by 11 publications

(12 citation statements)

References 27 publications

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“…[ 1 ]. Serotonin (5-HT), a tryptophan-derived biogenic amine, eventually endures oxidative deamination to form 5-hydroxyindolacetic acid (5-HIAA), has been found decreasing significantly in brains of insomnia [ 2 ], depression [ 3 ] and AD [ 4 ] rats. Dopamine (DA) and norepinephrine (NE), the metabolites of tyrosine (Tyr), are involved in sleep-wake cycles, learning, memory and emotion.…”

Section: Introductionmentioning

confidence: 99%

“…Dopamine (DA) and norepinephrine (NE), the metabolites of tyrosine (Tyr), are involved in sleep-wake cycles, learning, memory and emotion. A number of studies [ 2 , 3 , 4 ] have shown that the levels of DA and NE decreased significantly in the brains of depression and AD rats, counter to insomnia. Acetylcholine (ACh) is recognized participant in rapid eye movement (REM) sleep [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

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Targeted Neurotransmitters Profiling Identifies Metabolic Signatures in Rat Brain by LC-MS/MS: Application in Insomnia, Depression and Alzheimer’s Disease

Wang

Zhu

et al. 2018

Molecules

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Epidemiological, cross-sectional, and prospective studies have suggested that insomnia, Alzheimer’s disease (AD) and depression are mutually interacting conditions and frequently co-occur. The monoamine and amino acid neurotransmitter systems in central nervous system were involved in the examination of neurobiological processes of this symptom complex. However, few studies have reported systematic and contrastive discussion of different neurotransmitters (NTs) changing in these neurological diseases. Thus, it is necessary to establish a reliable analytical method to monitoring NTs and their metabolite levels in rat brain tissues for elucidating the differences in pathophysiology of these neurological diseases. A rapid, sensitive and reliable LC-MS/MS method was established for simultaneous determination of the NTs and their metabolites, including tryptophan (Trp), tyrosine (Tyr), serotonin (5-HT), 5-hydroxyindolacetic acid (5-HIAA), dopamine (DA), acetylcholine (ACh), norepinephrine (NE), glutamic acid (Glu), and γ-aminobutyric acid (GABA) in rat brain tissues. The mobile phase consisting of methanol and 0.01% formic acid in water was performed on an Inertsil EP C18 column, and the developed method was validated well. Results demonstrated that there were significant differences for 5-HT, DA, NE, Trp, Tyr and ACh between model and control group in all three models, and a Bayes linear discriminant function was established to distinguish these three kinds of nervous system diseases by DA, Tyr and ACh for their significant differences among control and three model groups. It could be an excellent strategy to provide perceptions into the similarity and differentia of mechanisms from the point of NTs’ changing in brain directly and a new method to distinguish insomnia, depression and AD from view of essence.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Targeted Neurotransmitters Profiling Identifies Metabolic Signatures in Rat Brain by LC-MS/MS: Application in Insomnia, Depression and Alzheimer’s Disease

Wang

Zhu

et al. 2018

Molecules

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“…The diagnostic criteria in Mongolian medicine were based on the diagnostic criteria for insomnia in the textbook of Internal Medicine of Mongolian Medicine for medical colleges and universities in China [6]. The primary symptoms include Haoyi blood and Haoyi Xila symptoms arising from prevalence of Haoyi, that is, difficulty falling asleep, easy awakening, inability to fall asleep after awakening, and pernoctation.…”

Section: Experimental Methodsmentioning

confidence: 99%

“…Negative moods such as tension, worry, fear, depression, and anxiety, and social environment, diet, daily life, movement, and so forth belong to external causes. Alleviating “Haoyi” and regulating equilibrium of “Sangen” are the main treatment principles [6]. Mongolian medicine improves sleep and treats insomnia by alleviating “Haoyi,” unclogging Haoyi blood, and balancing Sangen.…”

Section: Introductionmentioning

confidence: 99%

Clinical Trial Research on Mongolian Medical Warm Acupuncture in Treating Insomnia

Wang

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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Objective. Insomnia is one of the most common sleep disorders. Hypnotics have poor long-term efficacy. Mongolian medical warm acupuncture has significant efficacy in treating insomnia. The paper evaluates the role of Mongolian medical warm acupuncture in treating insomnia by investigating the Mongolian medicine syndromes and conditions, Pittsburgh sleep quality index, and polysomnography indexes. Method. The patients were diagnosed in accordance with International Classification of Sleep Disorders (ICSD-2). The insomnia patients were divided into the acupuncture group (40 cases) and the estazolam group (40 cases). The patients underwent intervention of Mongolian medical warm acupuncture and estazolam. The indicators of the Mongolian medicine syndromes and conditions, Pittsburgh sleep quality index (PSQI), and polysomnography indexes (PSG) have been detected. Result. Based on the comparison of the Mongolian medicine syndrome scores between the warm acupuncture group and the drug treatment group, the result indicated P < 0.01. The clinical efficacy result showed that the effective rate (85%) in the warm acupuncture group was higher than that (70%) in the drug group. The total scores of PSQI of both groups were approximated. The sleep quality indexes of both groups decreased significantly (P < 0.05). The sleep quality index in the Mongolian medical warm acupuncture group decreased significantly (P < 0.01) and was better than that in the estazolam group. The sleep efficiency and daytime functions of the patients in the Mongolian medical warm acupuncture group improved significantly (P < 0.01). The sleep time was significantly extended (P < 0.01) in the Mongolian medical warm acupuncture group following PSG intervention. The sleep time during NREM in the Mongolian warm acupuncture group increased significantly (P < 0.01). The sleep time exhibited a decreasing trend during REM and it decreased significantly in the Mongolian warm acupuncture group (P < 0.01). The percentage of sleep time in the total sleep time during NREM3+4 in the Mongolian medical warm acupuncture group increased significantly. Conclusion. Mongolian medical warm acupuncture is efficient and safe in treating insomnia. It is able to better improve the patients' sleep time and daytime functions. It is better than that in the estazolam group following drug withdrawal in terms of improving the sleep time. It is more effective in helping the insomnia patients than hypnotics.

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“…The patients were diagnosed in accordance with Standards for Diagnosis and Efficacy of TCM Symptoms and International Classification of Sleep Disorders (ICSD-2) by US Sleep Research Society [9]. The diagnostic criteria in Mongolian medicine were based on the diagnostic criteria for insomnia in the textbook of Internal Medicine of Mongolian Medicine for medical colleges and universities in China [6]. The primary symptoms include Haoyi blood and Haoyi Xila symptoms arising from prevalence of Haoyi, that is, difficulty falling asleep, easy awakening, inability to fall asleep after awakening, and pernoctation.…”

Section: Diagnostic Criteriamentioning

confidence: 99%

Clinical trial research on Mongolian medical warm acupuncture in treating insomnia

Sip¹

2018

Med Aromat Plants

Self Cite

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Objective. Insomnia is one of the most common sleep disorders. Hypnotics have poor long-term efficacy. Mongolian medical warm acupuncture has significant efficacy in treating insomnia. The paper evaluates the role of Mongolian medical warm acupuncture in treating insomnia by investigating the Mongolian medicine syndromes and conditions, Pittsburgh sleep quality index, and polysomnography indexes. Method. The patients were diagnosed in accordance with International Classification of Sleep Disorders (ICSD-2). The insomnia patients were divided into the acupuncture group (40 cases) and the estazolam group (40 cases). The patients underwent intervention of Mongolian medical warm acupuncture and estazolam. The indicators of the Mongolian medicine syndromes and conditions, Pittsburgh sleep quality index (PSQI), and polysomnography indexes (PSG) have been detected. Result. Based on the comparison of the Mongolian medicine syndrome scores between the warm acupuncture group and the drug treatment group, the result indicated < 0.01. The clinical efficacy result showed that the effective rate (85%) in the warm acupuncture group was higher than that (70%) in the drug group. The total scores of PSQI of both groups were approximated. The sleep quality indexes of both groups decreased significantly ( < 0.05). The sleep quality index in the Mongolian medical warm acupuncture group decreased significantly ( < 0.01) and was better than that in the estazolam group. The sleep efficiency and daytime functions of the patients in the Mongolian medical warm acupuncture group improved significantly ( < 0.01). The sleep time was significantly extended ( < 0.01) in the Mongolian medical warm acupuncture group following PSG intervention. The sleep time during NREM in the Mongolian warm acupuncture group increased significantly ( < 0.01). The sleep time exhibited a decreasing trend during REM and it decreased significantly in the Mongolian warm acupuncture group ( < 0.01). The percentage of sleep time in the total sleep time during NREM3+4 in the Mongolian medical warm acupuncture group increased significantly. Conclusion. Mongolian medical warm acupuncture is efficient and safe in treating insomnia. It is able to better improve the patients' sleep time and daytime functions. It is better than that in the estazolam group following drug withdrawal in terms of improving the sleep time. It is more effective in helping the insomnia patients than hypnotics.

show abstract

The effect of Mongolian medical acupuncture on cytokines and neurotransmitters in the brain tissue of insomniac rats

Cited by 11 publications

References 27 publications

Targeted Neurotransmitters Profiling Identifies Metabolic Signatures in Rat Brain by LC-MS/MS: Application in Insomnia, Depression and Alzheimer’s Disease

Targeted Neurotransmitters Profiling Identifies Metabolic Signatures in Rat Brain by LC-MS/MS: Application in Insomnia, Depression and Alzheimer’s Disease

Clinical Trial Research on Mongolian Medical Warm Acupuncture in Treating Insomnia

Clinical trial research on Mongolian medical warm acupuncture in treating insomnia

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