The effect of monaural middle ear destruction on postnatal development of auditory response properties of mouse inferior collicular neurons

Xu, Li; Jen, Philip H.‐S.

doi:10.1016/s0378-5955(01)00304-5

Cited by 9 publications

(8 citation statements)

References 36 publications

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“…Killackey and Ryugo [1977] reported that the laminated structure of the central nucleus of the IC of the rat is altered following unilateral but not bilateral ear canal closure. Their findings are supported by studies of Xu and Jen [2001] who report lack of a clear tonotopic organization of the IC of juvenile mice studied after middle ear destruction performed at 12-14 days after birth.…”

Section: Central Effects Of Unilateral Chlsupporting

confidence: 66%

“…The bilateral response to unilateral manipulation was also observed in our measurements of dendritic fields following unilateral CHL, where we identified an increase in dendritic length in both medial and lateral fields on both sides of the brain [Tucci et al, 2001]. Xu and Jen [2001] examined auditory response properties in IC neurons of juvenile and adult mice following unilateral middle ear destruction, producing permanent unilateral CHL. In animals of both age groups, units in the IC contralateral to the manipulated CHL ear were found to exhibit longer latencies, higher minimum thresholds, a smaller dynamic range, and degraded tuning curves compared to cells in the opposite IC, or in control animals.…”

Section: Central Effects Of Unilateral Chlsupporting

confidence: 59%

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Reversible Conductive Hearing Loss: Restored Activity in the Central Auditory System

2008

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The effect of a reversible, unilateral hearing loss on 2-deoxyglucose (2-DG) uptake in the central auditory system was studied using young gerbils. All animals had a unilateral conductive hearing loss (CHL), induced by atresia, on postnatal day 21 (P21). One week later, on P28, animals had their atresia repaired (CHL/R), or not repaired (CHL/NR), and CHL/NR animals entered the 2-DG experiments. CHL/R animals were allowed a 1-week period of restored binaural hearing experience prior to entering 2-DG experiments on P35. Animals in each group were injected with 2-DG and exposed to ambient sounds for 45 min prior to sacrifice. Uptake of 2-DG was measured in the anteroventral cochlear nucleus (AVCN), the medial superior olive (MSO), and the inferior colliculus (IC) on both sides of the brain. In CHL/NR animals, there were significant differences in uptake between the AVCN, MSO, and IC ipsilateral versus contralateral to the manipulated ear, indicating an imbalance in ascending afferent activity. In CHL/R animals, there were no significant differences, suggesting that 1 week after CHL repair, the appearance of balanced afferent activity had been restored.

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Section: Central Effects Of Unilateral Chlsupporting

confidence: 66%

Section: Central Effects Of Unilateral Chlsupporting

confidence: 59%

Reversible Conductive Hearing Loss: Restored Activity in the Central Auditory System

2008

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“…The hearing impairments investigated in previous studies (e.g. Popelar et al, 1994;Salvi et al, 2000;Syka, 2002;Wang et al, 2002;Barsz et al, 2007;Izquierdo et al, 2008;Sun et al, 2008) employed either interventions into the mature system to explore plasticity in adulthood (Wang et al, 1996(Wang et al, , 2002Rajan, 1998;Salvi et al, 2000;Barsz et al, 2007;Sun et al, 2008) or permanent destruction of a certain part of the auditory pathway before the onset of hearing to explore hearing-impairment-induced developmental anomalies (Kitzes & Semple, 1985;McAlpine et al, 1997;Shepherd et al, 1999;Xu & Jen, 2001;Vale et al, 2004;Kotak et al, 2005;Kral et al, 2005). However, to correctly identify the developmental changes induced by a hearing impairment, even the second method may be inadequate: the permanent nature of the impairment (e.g.…”

Section: Effect Of Hearing Impairment On the Representation Of Intensitymentioning

confidence: 99%

Noise exposure during early development impairs the processing of sound intensity in adult rats

Bureš

Grécová

Popelář

et al. 2010

Eur J of Neuroscience

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During the early postnatal development of rats, the structural and functional maturation of the central auditory nuclei strongly relies on the natural character of the incoming neural activity. Even a temporary deprivation in the critical period results in a deterioration of neuronal responsiveness in adult animals. We demonstrate that besides the poorer frequency selectivity of neurons in the impaired animals reported previously [Grecova et al. (2009)Eur. J. Neurosci. 29, 1921-1930], the neuronal representation of sound intensity is significantly affected. Rate-intensity functions of inferior colliculus neurons were recorded in anaesthetized adult rats that were exposed to intense noise at postnatal day 14, and compared with those obtained in age-matched controls. Although the response thresholds were similar in the exposed and control rats, the neurons in the exposed animals had a longer first-spike latency, a narrower dynamic range, lower maximum response magnitudes and a steeper slope of the rate-intensity functions. The percentage of monotonic neurons was significantly lower in the exposed animals. The observed anomalies were confined to the mid- and high-frequency regions, whereas no significant changes were found in the low-frequency neurons. The altered parameters of the individual rate-intensity functions led also to differences in the cumulative responses. We conclude that a brief noise exposure during the critical period leads to a frequency-dependent alteration of the sound intensity representation in the inferior colliculus of adult rats. The results suggest that such impairments may appear in individuals with normal hearing thresholds, but with a history of noise exposure very early in childhood.

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“…4), reflecting the total activity of ascending inputs to the IC (Nudo and Masterton, 1986;Brown et al, 1997), the nature of the outputs from that IC may be quite different in each condition. Given that unilateral CA eliminates information derived from one ear, while unilateral CHL only diminishes its central representation, CHL animals likely maintain some level of inhibition in the IC ipsilateral to the intact ear (Xu and Jen, 2001) while in CA animals the IC units have become more "excitable". Therefore, it would follow that the level of excitation present in the projection from the IC contralateral to the manipulated ear to the MG would be higher in CA animals than in CHL animals, affecting the activity in thalamocotical projections to auditory cortex, and the level of 2-DG uptake in auditory cortex.…”

Section: Sub-cortical Effects Of Unilateral Hearing Lossmentioning

confidence: 99%

“…Electrophysiological investigations of conductive hearing loss (CHL) in animals have shown that CHL changes the way sound is processed in the peripheral and central auditory system (e.g., Clopton and Silverman, 1978;Webster and Bobbin, 1986;Sumner et al, 2005;Xu and Jen, 2001;Jen and Xu, 2002;Xu et al, 2007). Centrally, unilateral CHL results in a decrease in glucose uptake as measured by the 2-deoxyglucose (2-DG) method, affecting cellular activity and metabolism in the major afferent projection from the manipulated ear (e.g., Tucci et al, 1999Tucci et al, , 2001.…”

Section: Introductionmentioning

confidence: 99%

Consequences of unilateral hearing loss: Cortical adjustment to unilateral deprivation

Hutson¹,

Durham²,

Imig³

et al. 2008

Hearing Research

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The effect of unilateral hearing loss on 2-deoxyglucose (2-DG) uptake in the central auditory system was studied in post-natal day 21 gerbils. Three weeks following a unilateral conductive hearing loss (CHL) or cochlear ablation (CA), animals were injected with 2-DG and exposed to an alternating auditory stimulus (1 and 2 kHz tones). Uptake of 2-DG was measured in the inferior colliculus (IC), medial geniculate (MG), and auditory cortex (fields AI and AAF) of both sides of the brain in experimental animals and in anesthesia-only sham animals (SH). Significant differences in uptake, compared to SH, were found in the IC contralateral to the manipulated ear (CHL or CA) and in AAF contralateral to the CHL ear. We hypothesize that these findings may result from loss of functional inhibition in the IC contralateral to CA, but not CHL. Altered states of inhibition at the IC may affect activity in pathways ascending to auditory cortex, and ultimately activity in auditory cortex itself. Altered levels of activity in auditory cortex may explain some auditory processing deficits experienced by individuals with CHL.

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The effect of monaural middle ear destruction on postnatal development of auditory response properties of mouse inferior collicular neurons

Cited by 9 publications

References 36 publications

Reversible Conductive Hearing Loss: Restored Activity in the Central Auditory System

Reversible Conductive Hearing Loss: Restored Activity in the Central Auditory System

Noise exposure during early development impairs the processing of sound intensity in adult rats

Consequences of unilateral hearing loss: Cortical adjustment to unilateral deprivation

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