The effect of molecules in mother-of-pearl on the decrease in bone resorption through the inhibition of osteoclast cathepsin K

Duplat, Denis; Gallet, Marlène; Berland, Sophie; Marie, Arul; Dubost, Lionel; Rousseau, Marthe; Kamel, Saı̈d; Milet, Christian; Brazier, Michel; Lopez, Évelyne; Bédouet, Laurent

doi:10.1016/j.biomaterials.2007.07.036

Cited by 25 publications

(25 citation statements)

References 29 publications

(39 reference statements)

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“…Zhang et al (2012), that 61 of the 259 shell proteins matched proteins in the exosome database (Zhang et al, 2012) and at least 48 specific genes which govern apoptotic cascades are also present in the oyster genome (Lacoste et al, 2002;Zhang et al, 2012). Furthermore, the fact that lipids with signaling properties and other cell signaling molecules are components of molluscan shell ECM extracts also lends support to this hypothesis Duplat et al, 2007;Farre and Dauphin, 2008;Mourie et al, 2002;Rousseau et al, 2006;Sud et al, 2001;Zhang et al, 2006). Cellular orchestration of biomineralization has also recently been shown to occur in mineralizing sea urchin embryos where a nanosphere-sized mineral was found inside intracellular vesicles and that vesicles were found in multiple cell types of the forming embryo (Vidavsky et al, 2014).…”

Section: Discussionmentioning

confidence: 73%

Cellular orchestrated biomineralization of crystalline composites on implant surfaces by the eastern oyster, Crassostrea virginica (Gmelin, 1791)

Johnstone

Gohad

Falwell

et al. 2015

Journal of Experimental Marine Biology and Ecology

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Section: Discussionmentioning

confidence: 73%

Cellular orchestrated biomineralization of crystalline composites on implant surfaces by the eastern oyster, Crassostrea virginica (Gmelin, 1791)

Johnstone

Gohad

Falwell

et al. 2015

Journal of Experimental Marine Biology and Ecology

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“…Findings showed that this may have been true of the increase in clastic cell adhesion; nevertheless, the organic matrix of dentin did not itself seem to cause the proresorptive effect on clastic cell activity, even when organic matrix from different substrates was used (Duplat et al 2007;Sriarj et al 2009). Bone marrow osteoclasts pretreated with extract of dentin organic matrix and cultured on ivory slices exhibited decreased resorptive activity (Sriarj et al 2009).…”

Section: Clastic Cell Adhesion: Integrins and Extracellular Matrix Prmentioning

confidence: 97%

Cellular and Molecular Pathways Leading to External Root Resorption

2016

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External apical root resorption during orthodontic treatment implicates specific molecular pathways that orchestrate nonphysiologic cellular activation. To date, a substantial number of in vitro and in vivo molecular, genomic, and proteomic studies have supplied data that provide new insights into root resorption. Recent mechanisms and developments reviewed here include the role of the cellular component-specifically, the balance of CD68 + , iNOS + M1-and CD68 + , CD163 + M2-like macrophages associated with root resorption and root surface repair processes linked to the expression of the M1-associated proinflammatory cytokine tumor necrosis factor, inducible nitric oxide synthase, the M1 activator interferon γ, the M2 activator interleukin 4, and M2-associated anti-inflammatory interleukin 10 and arginase I. Insights into the role of mesenchymal dental pulp cells in attenuating dentin resorption in homeostasis are also reviewed. Data on recently deciphered molecular pathways are reviewed at the level of (1) clastic cell adhesion in the external apical root resorption process and the specific role of α/β integrins, osteopontin, and related extracellular matrix proteins; (2) clastic cell fusion and activation by the RANKL/RANK/OPG and ATP-P2RX7-IL1 pathways; and (3) regulatory mechanisms of root resorption repair by cementum at the proteomic and transcriptomic levels.

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“…Previous studies have shown the functional nature of nacre as a biomaterial for bone repair after its successful in vivo implantation in sheep femur, where it triggered bone remodeling at the interphase between bone and nacre implant (Atlan et al, 1999). Fragments of nacre from the bivalve Pinctada maxima when implanted into the bone of rats, sheep, dogs, and humans elicited a biological response including local osteogenic activity and incorporation of the nacre, without any inflammatory reaction (Duplat et al, 2007;Benkendorff, 2010). Studies conducted by Fujita et al suggest that a bioavailable form of calcium carbonate from Oyster shell lysate of Ostrea edulis can be used for the treatment of osteoporosis patients (Fujita et al, 1993).…”

Section: Marine Molluscsmentioning

confidence: 99%

“…Studies conducted by Fujita et al suggest that a bioavailable form of calcium carbonate from Oyster shell lysate of Ostrea edulis can be used for the treatment of osteoporosis patients (Fujita et al, 1993). The water-soluble fraction of nacre extract reduced the osteoclastic resorption activity by inhibiting cathepsin K without reducing the osteoclast number, adhesion, and survival (Duplat et al, 2007). N16, derived from the nacreous layer of a pearl oyster Pinctada fucata, is a protein that promotes biomineralization, however; it inhibits RANKL induced osteoclast differentiation.…”

Section: Marine Molluscsmentioning

confidence: 99%

Marine Natural Products: New Avenue in Treatment of Osteoporosis

Chaugule¹,

Indap²,

Chiplunkar

2017

Front. Mar. Sci.

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Bone metabolism is a physiological process that maintains the skeletal integrity and bone functions. Skeletal integrity is always balanced by two key cell types-bone resorbing osteoclasts and bone-forming osteoblasts. Imbalance between generation and function of osteoclasts and osteoblasts often leads to pathological conditions such as osteoporosis, osteopetrosis, Paget's disease. Osteoporosis is one of the most common age-related diseases characterized by decreased bone mineral density and microarchitectural deterioration. Current therapies are indeed effective in preventing bone loss but are also followed by side effects. Since many years, marine organisms have been considered as a good source of bioactive molecules or compounds with potential pharmaceutical properties. Marine Natural Products (MNPs) derived from various marine resources such as marine cyanobacteria, dinoflagellates, algae, sponges, soft corals, molluscs, fishes, and mangroves had shown profound effect on bone metabolism through inhibiting osteoclastogenesis and up-regulating osteoblastogenesis via modulating RANK/RANKL/OPG pathway. Amongst the pre-clinically investigated MNPs for management of osteoporosis, very few are under phase I clinical trials. This review discusses the currently available pharmacological drugs and there major health concern in osteoporosis treatment. It further gives an insight into various marine resources and marine-derived bioactive products, depicting their mechanism of action, functional role, and how these can be exploited for the treatment of osteoporosis.

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The effect of molecules in mother-of-pearl on the decrease in bone resorption through the inhibition of osteoclast cathepsin K

Cited by 25 publications

References 29 publications

Cellular orchestrated biomineralization of crystalline composites on implant surfaces by the eastern oyster, Crassostrea virginica (Gmelin, 1791)

Cellular orchestrated biomineralization of crystalline composites on implant surfaces by the eastern oyster, Crassostrea virginica (Gmelin, 1791)

Cellular and Molecular Pathways Leading to External Root Resorption

Marine Natural Products: New Avenue in Treatment of Osteoporosis

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