The effect of molecular weight on the crystallization kinetics of polycaprolactone

Jenkins, Michael J.; Harrison, Kate

doi:10.1002/pat.733

Cited by 158 publications

(121 citation statements)

References 23 publications

Supporting

Mentioning

107

Contrasting

Unclassified

Order By: Relevance

“…The extrusion process was carried out at temperatures (110-130°C) above PCL melting temperature and well below PCL starting degradation temperature, to avoid degradation phenomena of the polymer during tube manufacturing. Calorimetric properties of PCL before and after extrusion were similar, except for a higher crystallisation temperature of the extruded polymer as compared to native PCL: this result could suggest some molecular weight decrease of PCL during processing, due to combined thermal and mechanical stress, accelerating its crystallisation rate (Jenkins and Harrison 2006).…”

Section: Discussionmentioning

confidence: 93%

Melt-extruded guides for peripheral nerve regeneration. Part I: Poly(ε-caprolactone)

Chiono

Vozzi

et al. 2009

Biomed Microdevices

View full text Add to dashboard Cite

Melt-extruded guides for peripheral nerve repair based on poly(epsilon-caprolactone) (PCL) were realised and their physico-chemical properties were evaluated. Preliminarily, PCL cast films were found to support the attachment and proliferation of Neonatal Olfactory Bulb Ensheating Cells (NOBEC). S5Y5 neuroblastoma cells were cultured inside PCL guides in their uncoated form or coated with a non-specific adhesion protein (gelatin) and a specific peptide for nerve regeneration (poly(L-lysine)). Coating increased cell density (gelatin) and/or the cell density rate on substrates (poly(L-lysine); gelatin) as compared to uncoated guides. Various in vivo tests were carried out for the repair of small (0.5 cm), medium (1.5 cm) and long (4.5 cm) size defects in the peripheral nerves of Wistar rats. For the small nerve defects, uncoated and coated PCL guides were tested. Results from in vivo tests were subjected to histological examination after 45 days, 6 and 8 months postoperative for small, medium and large defects, respectively. Regeneration was found for small and medium size defects. For 0.5 cm defects, the coating did not affect regeneration significantly. Grip-tests also evidenced functional recovery for the 1.5 cm-long defects treated with PCL guides, after 6 months from implantation. On the other hand, mechanical stiffness of PCL conduits impaired the repair of 4.5 cm-long defects in 8-month period: the lack of flexibility of the guide to rat movements caused its detachment from the implant site. The research showed that PCL guides can be used for the successful repair of small and medium size nerve defects, with possible improvements by suitable bio-mimetic coatings.

show abstract

Section: Discussionmentioning

confidence: 93%

Melt-extruded guides for peripheral nerve regeneration. Part I: Poly(ε-caprolactone)

Chiono

Vozzi

et al. 2009

Biomed Microdevices

View full text Add to dashboard Cite

show abstract

“…As seen from Table I, with increase in T c , the Avrami rate constant (Z t ) decreased; this was evident from the literature published. 59 This suggests that at low T c 's, the high degree of undercooling overcame the energy barrier quickly and easily contributed toward less time and faster crystallization.…”

Section: Avrami Model For Isothermal Crystallizationmentioning

confidence: 98%

Isothermal and nonisothermal crystallization kinetics of poly(ϵ‐caprolactone)

Dhanvijay

Shertukde

Kalkar

2011

J of Applied Polymer Sci

View full text Add to dashboard Cite

With increasing environmental awareness, evaluating the potential of biopolymers as a substitute for traditional materials has been of great interest. Crystallization kinetics provides fundamental knowledge required for evaluation, playing vital role in determining the final properties of the product. In this study, the isothermal and nonisothermal crystallization kinetics of poly(e-caprolactone) (PCL) were investigated with the help of various models. The Avrami model best described the isothermal crystallization kinetics, suggesting three-dimensional spherulitic growth, which was in agreement with the morphology studies; whereas the Liu model fit well under nonisothermal crystallization conditions. The failure of the Kissinger model to determine the activation energy was overcome with the Friedman model. The kinetic crystallizability determined by the Ziabacki model indicated a higher crystallization ability of PCL at lower cooling rates.

show abstract

“…In addition, its great permeability to various molecules [9,10] PCL, due to its high crystallinity, biodegrades slowly and is completely degraded after 2-4 years depending on the geometry and the initial molecular weight of the device or implant [11][12][13][14][15]. Amorphous regions are preferentially degraded, since water absorption is impeded in the crystalline zones [16][17][18][19][20][21][22]. In consequence, the rate of biodegradation of the polyesters is significantly influenced by their crystallization capability [23,24].…”

Section: Introductionmentioning

confidence: 99%

In vitro degradation studies and mechanical behavior of poly(ε-caprolactone-co-δ-valerolactone) and poly(ε-caprolactone-co-L-lactide) with random and semi-alternating chain microstructures

Fernández

Etxeberria

Sarasua

2015

European Polymer Journal

View full text Add to dashboard Cite

The effect of molecular weight on the crystallization kinetics of polycaprolactone

Cited by 158 publications

References 23 publications

Melt-extruded guides for peripheral nerve regeneration. Part I: Poly(ε-caprolactone)

Melt-extruded guides for peripheral nerve regeneration. Part I: Poly(ε-caprolactone)

Isothermal and nonisothermal crystallization kinetics of poly(ϵ‐caprolactone)

In vitro degradation studies and mechanical behavior of poly(ε-caprolactone-co-δ-valerolactone) and poly(ε-caprolactone-co-L-lactide) with random and semi-alternating chain microstructures

Contact Info

Product

Resources

About