The Effect of Modification of Hydroxyapatite Whisker with Zinc Acetate via Sol-Gel Technology

Jin, Jiaxin; Liu, Wen Ying; Zhang, Wen Yun; Chen, Qing Hua; Yuan, Yan Bo; Yang, Li Dou; Yu, Xiao; Li, Ming Qiu

doi:10.4028/www.scientific.net/amm.364.655

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“…While Ca 2+ lay on the crystal surface, Zn 2+ , HAPw and -OH from PEG-6000 existed in the identical liquid phase, and Ca (I) could shape stronger absorption sites to attract Zn 2+ after calcinating Zn 2+ fused on the surface of HAPw [30,31]. The variable morphology of ZnO nanoparticles in the composite, such as triangular, short, rod-like and screw-shaped, may be found in our previous study [32]. Agglomeration was likely to be present in the synthetic process of the HAPw/n-ZnO composite; accordingly, superficial dispersants such as PEG-6000 incorporated with ultrasonication were employed to decompose the agglomerates.…”

Section: Discussionmentioning

confidence: 59%

Synthesis, characterization, antimicrobial activity and mechanism of a novel hydroxyapatite whisker/nano zinc oxide biomaterial

et al. 2014

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Postoperative infections remain a risk factor that leads to failures in oral and maxillofacial artificial bone transplantation. This study aimed to synthesize and evaluate a novel hydroxyapatite whisker (HAPw) / nano zinc oxide (n-ZnO) antimicrobial bone restorative biomaterial. A scanning electron microscope (SEM), energy dispersive spectroscopy (EDS) and x-ray diffraction (XRD) were employed to characterize and analyze the material. Antibacterial capabilities against Staphylococcus aureus, Escherichia coli, Candida albicans and Streptococcus mutans were determined by minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC), and kinetic growth inhibition assays were performed under darkness and simulated solar irradiation. The mode of antibiotic action was observed by transmission electron microscopy (TEM) and confocal laser scanning microscopy (CLSM). The MIC and MBC were 0.078-1.250 mg ml(-1) and 0.156-2.500 mg ml(-1), respectively. The inhibitory function on the growth of the microorganisms was achieved even under darkness, with gram-positive bacteria found to be more sensitive than gram-negative, and enhanced antimicrobial activity was exhibited under simulated solar excitation compared to darkness. TEM and CLSM images revealed a certain level of bacterial cell membrane destruction after treatment with 1 mg ml(-1) of the material for 12 h, causing the leakage of intracellular contents and bacteria death. These results suggest favorable antibiotic properties and a probable mechanism of the biomaterial for the first time, and further studies are needed to determine its potential application as a postoperative anti-inflammation method in bone transplantation.

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Section: Discussionmentioning

confidence: 59%