The Effect of Moderate Aerobic Training on Lymphocyte Proliferation

Mitchell, Joel B.; Paquet, A.; Pizza, Francis X.; Starling, Raymond D.; Holtz, Robert; Grandjean, Peter W.

doi:10.1055/s-2007-972865

Cited by 33 publications

(30 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The mechanisms involved in the diVerent eVects of exercise on the immune system are not fully understood and seem to be multi-factorial, including endocrine changes and alterations in plasma glutamine concentrations (Mitchell et al 1996;Nieman and Pedersen 1999;Pedersen and Toft 2000;Bassit et al 2000;Castell 2002Castell , 2003Cunha et al 2003;Costa Rosa 2004).…”

Section: Introductionmentioning

confidence: 99%

Effect of exercise on glutamine metabolism in macrophages of trained rats

et al. 2009

View full text Add to dashboard Cite

This study investigated the effect of exercise on glutamine metabolism in macrophages of trained rats. Rats were divided into three groups: sedentary (SED); moderately trained (MOD) rats that were swim trained 1 h/day, 5 days/week for 6 weeks; and exhaustively trained (EXT) rats that were similarly trained as MOD for 5 weeks and, in the 6th week, trained in three 1-h sessions/day with 150 min of rest between sessions. The animals swam with a load equivalent to 5.5% of their body weight and were killed 1 h after the last exercise session. Cells were collected, and glutamine metabolism in macrophage and function were assayed. Exercise increased phagocytosis in MOD when compared to SED (34.48 +/- 1.79 vs 15.21 +/- 2.91%, P < 0.05); however, H(2)O(2) production was higher in MOD (75.40 +/- 3.48 nmol h x 10(5) cell(-1)) and EXT (79.20 +/- 1.18 nmol h x 10(5) cell(-1)) in relation to SED (32.60 +/- 2.51 nmol h x 10(5) cell(-1), P < 0.05). Glutamine consumption increased in MOD and EXT (26.53 +/- 3.62 and 19.82 +/- 2.62 nmol h x 10(5) cell(-1), respectively) relative to SED (6.72 +/- 0.57 nmol h x 10(5) cell(-1), P < 0.05). Aspartate increased in EXT (9.72 +/- 1.14 nmol h x 10(5) cell(-1)) as compared to SED (1.10 +/- 0.19 nmol h x 10(5) cell(-1), P < 0.05). Glutamine decarboxylation was increased in MOD (12.10 +/- 0.27 nmol h x 10(5) cell(-1)) and EXT (16.40 +/- 2.17 nmol h x 10(5) cell(-1)) relative to SED (1.10 +/- 0.06 nmol h x 10(5) cell(-1), P < 0.05). This study suggests an increase in macrophage function post-exercise, which was supported by enhanced glutamine consumption and metabolism, and highlights the importance for glutamine after exercise.

show abstract

Section: Introductionmentioning

confidence: 99%

Effect of exercise on glutamine metabolism in macrophages of trained rats

et al. 2009

View full text Add to dashboard Cite

show abstract

“…Mackinnon (1996) reports that the IgA class of antibodies primarily interact and defend the various secretory surfaces from invasion; therefore, [IgA] can readily be measured in tears, saliva, or fluids from the respiratory, genito-urinary and gastro-intestinal tracts. Although heavy exercise has been shown to decrease markedly the IgA concentrations of both nasal and salivary ([IgA s ]) samples (Tharp and Barnes 1989;Mackinnon and Jenkins 1993), the few studies that have examined the effects of moderate exercise on [IgA s ] have been inconclusive (Schouten et al 1988;Nehlsen-Cannarella et al 1990;Karper and Goldfarb 1995;Mitchell et al 1996).…”

Section: Introductionmentioning

confidence: 99%

Effect of moderate exercise on salivary immunoglobulin A and infection risk in humans

Klentrou

Cieslak

MacNeil

et al. 2002

European Journal of Applied Physiology

140

111

View full text Add to dashboard Cite

The incidence of upper respiratory tract infections (URTI) and salivary immunoglobulin A concentrations [IgA(s)] of nine individuals were examined during 12 weeks of moderate exercise training, and compared to ten sedentary controls. Changes in maximal oxygen uptake were assessed at initial, mid-point and final evaluations (T1-3), while changes in [IgA(s)] and salivary immunoglobulin concentration-salivary albumin concentration ratio ([IgA(s)]:[Alb(s)]) were monitored at T1 and T3. During the 12 week period, symptoms of URTI were self-recorded daily. During the period of training the level of fitness significantly increased ( P<0.05) in the exercise group. The number of days recording symptoms of influenza, but not of cold, and total light URTI symptoms was significantly reduced in the exercise group during the last weeks of training. A significant increase in [IgA(s)] and in [IgA(s)]:[Alb(s)] was found in the exercise group after training. Both [IgA(s)] and [IgA(s)]:[Alb(s)] were significantly related to the number of days showing symptoms of influenza ( P<0.01) and the total number of days of sickness ( P<0.05). These data provide quantitative support for the belief that regular, moderate exercise results in an increased [IgA(s)] at rest and [IgA(s)]:[Alb(s)], which may contribute to a decreased risk of infection.

show abstract

“…Recent studies suggest that strenuous swimming training of athletes increases susceptibility to infection and that moderate intensity exercise reduces immunity in young healthy individuals (Mitchell et al, 1996;Pedersen, 1997;Pedersen et al, 1998). Peijie et al (2003) reported that 6-week heavy load training induced immune system dysfunction in SD rats, but moderate exercise increased T-cell subsets relative to heavy load training.…”

Section: Discussionmentioning

confidence: 99%

Effects of Swimming Training on Immune Function of Growing Rats Fed a High-Fat Diet

Kwon

Hwang

Kim

et al. 2005

JHES

View full text Add to dashboard Cite

The effects of swimming exercise on immune function of growing rats fed a high-fat diet were studied. Thirty-four male rats were randomly divided into 4 groups: CS (control diet sedentary group, n‫,)8؍‬ CE (control diet exercised group, n‫,)9؍‬ HS (high-fat diet sedentary group, n‫)8؍‬ and HE (high-fat diet exercised group, n‫.)9؍‬ The high-fat diet was included 35% carbohydrate, 20% protein and 35% fat. AIN-76 was used as the control diet. In the exercised groups, the rats swam for 60 min day ؊1 , 5 days/week for 4 weeks. Mean blood glucose, total cholesterol, and triglyceride levels were not significantly different between groups, and neither were mean soleus muscle mitochondrial citrate synthase activities. However, the CD4؉/CD8؉ ratio (pϽ0.05) and the glycogen content of the plantarius muscle were significantly lower in the HS group than in the CS group. The CD4؉ T cell population of the spleen and the glycogen content of the plantarius muscle were significantly higher in the HE group than in the HS group (pϽ0.01 and pϽ0.05 respectively). Interleukin-2 production following 5 mg/ml of conconavalin A (Con. A) stimulation tended to be higher in the HE group than in the other groups but the difference was not statistically significant. It is suggested that regular endurance exercise in growing rats fed a high-fat diet increases the CD4؉ T cell subpopulation by stimulating interleukin-2 production.

show abstract

The Effect of Moderate Aerobic Training on Lymphocyte Proliferation

Cited by 33 publications

References 1 publication

Effect of exercise on glutamine metabolism in macrophages of trained rats

Effect of exercise on glutamine metabolism in macrophages of trained rats

Effect of moderate exercise on salivary immunoglobulin A and infection risk in humans

Effects of Swimming Training on Immune Function of Growing Rats Fed a High-Fat Diet

Contact Info

Product

Resources

About