The Effect of Mixing on the Metastable Zone Width and Nucleation Kinetics in the Anti-Solvent Crystallization of Benzoic Acid

O'grady, Des; Barrett, Mark; Casey, Eoin; Glennon, Brian

doi:10.1205/cherd06207

Cited by 125 publications

(139 citation statements)

References 29 publications

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“…Increasing interest in the determination and theoretical interpretation of metastable zone width in antisolvent crystallization started relatively recently after the publication of a paper by O'Grady et al (2007). These authors carried out measurements of metastable zone width in antisolvent crystallization of benzoic acid in a water−ethanol mixture and, following the classical approach of Nývlt for crystallization from solution by cooling at a constant rate (Nývlt et al, 1985), first derived a relation, which they called modified Nývlt relation, between the maximum antisolvent composition Δx max added to a solution saturated at a given temperature T, and the rate of addition of the antisolvent R A .…”

Section: Prefacementioning

confidence: 99%

Nucleation and Crystal Growth

Sangwal¹

2018

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Section: Prefacementioning

confidence: 99%

Nucleation and Crystal Growth

Sangwal¹

2018

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“…A programmable heater / chiller that circulate ethylene-glycol solution through the jacket vessel control the solution temperature, as well as the heating / cooling rates. The temperature of the solution is measured with a digital thermocouple [8,9].…”

Section: Experimental Methodsmentioning

confidence: 99%

Metastability of CuCl2 in H2O-HCl for the Copper-Chlorine Thermochemical Cycle of Hydrogen Production

Lescisin¹,

Ma²,

Oa³

et al. 2017

J Chem Eng Process Technol

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In this paper, metastability of CuCl 2 in H 2 O-HCL for applications to the Cu-Cl thermochemical cycle is experimentally investigated to decrease crystallizing (precipitating) temperature and reduce thermal energy requirements of the cycle. Metastability delays the phase transition by altering the phase transition temperature, depending on direction (heating or cooling). The dissolving temperature is increased if the solution is heated and decreased if the solution is cooled, whereas a typical simple solubility model assumes dissolving and crystallizing occur at the same temperature. The solution temperature is controlled using an ethylene-glycol heater/chiller and measured with a thermocouple. The results of this paper show the metastable zone width increases with cooling rate and is unaffected by HCL concentration. The solubility product constant is calculated for CuCl 2 dissolving in various concentrations of HCL and decreases with increasing temperature and HCL concentration.

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“…Generally the goal is to detect the formation of particles as close as possible to the actual nucleation (formation of critical cluster). In order to determine the MSZW several sensors can be considered: turbidity (Parsons et al, 2003), focused beam reflectance measurement (Fujiwara et al, 2002, O'Grady et al, 2007, spectroscopy (Fujiwara et al, 2002, O'Grady et al, 2007, Pollanen et al, 2006, ultrasonic velocity measurements (Gurbuz and Ozdemir, 2003), density (Marciniak, 2002a) and electrical conductivity monitoring (Lyczko et al, 2002), hot stage microscopy (Kumar et al, 1996), quartz crystal based monitoring (Joung et al, 2005, Loffelmann andMersmann, 2002), and last but not least by visual inspection of the crystallizer content (Sohnel and Mullin, 1988).…”

Section: Introductionmentioning

confidence: 99%

Comparison of external bulk video imaging with focused beam reflectance measurement and ultra-violet visible spectroscopy for metastable zone identification in food and pharmaceutical crystallization processes

Simon

Nagy

Hungerbühler

2009

Chemical Engineering Science

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• This is a journal article. It was published in the Chemical Engi- The purpose of the paper is twofold: it describes the proof of concept of the newly introduced bulk video imaging (BVI) method and it presents the comparison with existing process analytical technologies (PAT) such as focused beam reflectance measurement (FBRM) and ultra violet/visible (UV/Vis) spectroscopy. While the latter two sample the system in small volumes closely to the probe, the BVI approach monitors the entire or large parts of the crystallizer volume. The BVI method is proposed as a complementary noninvasive PAT tool and it is shown that it is able to detect the boundaries of the metastable zone with comparable or better performance than the FBRM and UV/VIS probes.

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The Effect of Mixing on the Metastable Zone Width and Nucleation Kinetics in the Anti-Solvent Crystallization of Benzoic Acid

Cited by 125 publications

References 29 publications

Nucleation and Crystal Growth

Nucleation and Crystal Growth

Metastability of CuCl2 in H2O-HCl for the Copper-Chlorine Thermochemical Cycle of Hydrogen Production

Comparison of external bulk video imaging with focused beam reflectance measurement and ultra-violet visible spectroscopy for metastable zone identification in food and pharmaceutical crystallization processes

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