The effect of mitomycin C as fibrosis preventive agent during craniectomies

Abstract

Epidural fibrosis can be a devastating condition that forms after craniectomy. Topical application of mitomycin C may be a successful method of preventing epidural fibrosis following craniectomy.

Age-dependence of intracranial viscoelastic properties in living rats

“…Second, dura mater is significantly stiffer than brain tissue, and the magnitude of the difference increases as the size of the animal (and consequently thickness of the dura) increases (Galford and McElhaney, 1970;Ozawa et al, 2004;Fiford and Bilston, 2005;Maikos et al, 2008;Persson et al, 2010a,b). The rat cranial dura is ∼13 µm thickness and is only loosely adherent to the skull (Cemil et al, 2009). Experiments with uniaxial tension applied at low and high strain rates lead to the conclusion that "the rat dura mater is significantly stiffer than the CNS tissue it surrounds" (Fiford and Bilston, 2005;Maikos et al, 2008).…”

Persistent Intracranial Hypertension in a Cranial Vault Remodeling Patient With Open Skull Fractures From Horse Kick

“…The possibility of underlying dural scarring or adhesions from prior surgery may have acted as a barrier to decompression of the cerebrum. Soft tissue adhesions between the dura, temporalis muscle, and galea have been noted by neurosurgeons in cranioplasties following decompressive craniectomies (Cemil et al, 2009; Rocque et al, 2018). Finally, the patient’s refractory ICPs may have been simply due to her severe cranial trauma from horse kick.…”