The Effect of miR-145-5p, DANCR and NRAS Expression Levels on the Survival Rate of Colorectal Cancer Patients

Abstract

According to the results of the study 2017, the age-adjusted incidence of colorectal cancer in Iran between 1990 and 2017 increased about 3.63%. Statistics show that the incidence and mortality of colorectal cancer are increasing in low-and middle-income countries, while in developed countries it is stable or declining

Expression Status of Rap1 Pathway-Related Genes in Liver Metastases Compared with Corresponding Primary Colorectal Cancer

“…Approximately 3–5% of patients with CRLM have mutations within the NRAS gene [ 17 ]. A recent case–control study revealed that high expression of NRAS can increase the risk of CRC death up to four times (HR = 4.12, p = 0.045) [ 43 ]. In addition, Rezaei et al found that KDR was expressed at significantly higher levels in CRC tissues than in adjacent noncancerous tissues [ 13 ].…”

“…In contrast, when comparing gene expression in primary CRC tissues and adjacent noncancerous tissues, no statistically significant difference between the mRNA level of KDR in non-metastatic patients was found, implicating KDR as an interesting molecule to study further in the specific context of metastasis. 0.045) [43]. In addition, Rezaei et al found that KDR was expressed at significantly higher levels in CRC tissues than in adjacent noncancerous tissues [13].…”