The Effect of Minocycline on Fat Graft Survival and Apoptotic Pathway

Güney, Kırdar; Tatar, Sedat; Özel, Begüm; Seymen, Cemile Merve; Elmas, Çiğdem; Tuncer, Serhan; Çenetoğlu, Seyhan

doi:10.1055/s-0039-1677709

Cited by 15 publications

(13 citation statements)

References 32 publications

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“…That is why there is no alteration in the epidermal thickness. This is also being the findings of Guneyet al that demonstrate the antiapoptotic effects of minocycline on fat graft and observed statisticallysignificant apoptosis inhibition 21 . This has also being proven in the study conducted by Abbaszuddenet al who found that minocycline protects neurons from caspase activation through decrease release of cytochrome C from mitochondria and also reduces the levels of TNF 22 .…”

Section: Groupsupporting

confidence: 70%

Impeding Minocycline Induced Hyperpigmentation by Pomegranate Extracting the Epidermis of Guinea Pig

Fatimee¹,

Younus²,

Sundus³

et al. 2020

J. Bahria Univ. Med. Dent. Coll.

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Objective: This study was planned over the hypothesis that pomegranate extract rich in ellagic acid used with minocycline could decrease its adverse effect and prolong its therapeutic use and efficacy. Study design and Setting: This experimental study was done in the department of anatomy, Basic Medical Sciences Institute, Jinnah Postgraduate Medical Center, Karachi, Methodology: We acquired 40 guinea pigs (male, adult, 450 – 550 gm), randomly divided them into 4 groups.Group B received 0.0003mg/g bodyweight of minocycline only, group C was given 0.0003mg/g bodyweight of minocycline with 0.4mg/g bodyweight of pomegranate, group D was given 0.4mg/g bodyweight pomegranate only; with keeping group A with no intervention at laboratory diet for 8 weeks. After the experimental period, the animals were sacrificed, H & E and DOPA-OXIDASE staining was done on harvested skin tissues for morphometric observations under light microscopy. Results: The results showed that minocycline induced reduction in mean thickness of epidermis and increased melanin pigment deposition. Mean number of melanocytes decreased with pomegranate use though the difference was insignificant (P-value > 0.05) but consistent and measurable. Conclusions: It was proven that by including pomegranate in our daily diet, the process of hyperpigmentation of skin induced by the broad spectrum tetracycline particularly minocycline, can be slow down by decreasing the activity of tyrosinase enzyme, thus it provides a novel pathway to fight against any other drug induced hyperpigmentation occurring due to increase activity of tyrosinase enzyme

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Section: Groupsupporting

confidence: 70%

Impeding Minocycline Induced Hyperpigmentation by Pomegranate Extracting the Epidermis of Guinea Pig

Fatimee¹,

Younus²,

Sundus³

et al. 2020

J. Bahria Univ. Med. Dent. Coll.

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“…Rapid vascularisation seems crucial, 30 and until then the graft has to be protected from harmful impacts such as mechanical cues or infectious agents. Moreover, antiapoptotic effects on free fat grafts exerted by certain antibiotic substances have been postulated 31 . Hence, most surgeons prefer to add antibiotics to their postoperative regime following autologous lipotransfer with the goal of maximising safety of the procedure.…”

Section: Discussionmentioning

confidence: 99%

Prolonged antibiotic prophylaxis in tissue reconstruction using autologous fat grafting: Is there a benefit for wound healing?

Morandi

Winkelmann

Dostal

et al. 2021

International Wound Journal

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Fat grafting is a well‐established method in plastic surgery. Despite many technical advances, standardised recommendations for the use of prophylactic antibiotics in fat grafting are not available. This retrospective multicentre study aims to analyse the use of prophylactic antibiotics in fat grafting and to compare complication rates for different protocols. A retrospective medical chart review of 340 patients treated with fat grafting of the breast from January 2007 to March 2019 was performed in three plastic surgery centres. Complications, outcomes, and antibiotic regimes were analysed. The Clavien‐Dindo classification was applied. All patients received perioperative antibiotic prophylaxis: 33.8% (n = 115) were treated with a single shot (group 1), 66.2% (n = 225) received a prolonged antibiotic scheme (group 2). There was no significant difference in the number of sessions (P = .475). The overall complication rate was 21.6% (n = 75), including graft resorption, fat necrosis, infection, and wound healing problems. Complication rates were not significantly different between groups. Risk factors for elevated complication rates in this specific patient group are smoking, chemotherapy, and irradiation therapy. The complication rate for lipografting of the breast is low, and it is not correlated to the antibiotic protocol. The use of prolonged prophylactic antibiotics does not lower the complication rate.

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“…Adipocytes represent the major cell type in absorbed cell type in the fat graft. In the model of the fat implant to the dorsal area of rats, Güney et al verified that the adipocyte apoptosis could be inhibited by utilizing minocycline, thereby increased fat graft survival characterized by bigger graft volume, better fat structures coupled with more vascular 16 . And this apoptosis could be antagonized by synthetic glucocorticoid and insulin-like growth factor-1 (IGF-1) 17 .…”

Section: Adipocyte Apoptosismentioning

confidence: 99%

Deciphering the Emerging Roles of Adipocytes and Adipose-Derived Stem Cells in Fat Transplantation

Zhao

et al. 2021

Cell Transplant

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Autologous fat transplantation is widely regarded as an increasingly popular method for augmentation or reshaping applications in soft tissue defects. Although the fat transplantation is of simple applicability, low donor site morbidity and excellent biocompatibility, the clinical unpredictability and high resorption rates of the fat grafts remain an inevitable problem. In the sites of fat transplantation, the most essential components are the adipocyte and adipose-derived stem cells (ADSCs). The survival of adipocytes is the direct factor determining fat retention. The efficacy of fat transplantation is reduced by fat absorption and fibrosis due to the inadequate blood flow, adipocyte apoptosis and fat necrosis. ADSCs, a heterogeneous mixture of cells in adipose tissue, are closely related to tissue survival. ADSCs exhibit the ability of multilineage differentiation and remarkable paracrine activity, which is crucial for graft survival. This article will review the recent existing research on the mechanisms of adipocytes and ADSCs in fat transplantation, especially including adipocyte apoptosis, mature adipocyte dedifferentiation, adipocyte browning, ADSCs adipogenic differentiation and ADSCs angiogenesis. The in-depth understanding of the survival mechanism will be extremely valuable for achieving the desired filling effects.

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The Effect of Minocycline on Fat Graft Survival and Apoptotic Pathway

Cited by 15 publications

References 32 publications

Impeding Minocycline Induced Hyperpigmentation by Pomegranate Extracting the Epidermis of Guinea Pig

Impeding Minocycline Induced Hyperpigmentation by Pomegranate Extracting the Epidermis of Guinea Pig

Prolonged antibiotic prophylaxis in tissue reconstruction using autologous fat grafting: Is there a benefit for wound healing?

Deciphering the Emerging Roles of Adipocytes and Adipose-Derived Stem Cells in Fat Transplantation

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