The effect of mild endotoxemia during low arginine plasma levels on organ blood flow in rats

Prins, Hubert A.; Houdijk, Alexander P. J.; Wiezer, Marinus J.; Teerlinck, T.; Lambalgen, A.A. van; Thijs, L. G.; Leeuwen, Paul A. M. van

doi:10.1097/00003246-200006000-00051

Cited by 23 publications

(13 citation statements)

References 25 publications

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“…Data of the total hepatic blood flow are in good accordance with the results of previously published studies (3,(25)(26)(27), underlining the reliability of the present methodological approach.…”

Section: Discussionsupporting

confidence: 89%

H₂S contributes to the hepatic arterial buffer response and mediates vasorelaxation of the hepatic artery via activation of K_ATP channels

Siebert¹,

Cantré²,

Eipel³

et al. 2008

American Journal of Physiology-Gastrointestinal and Liver Physi

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Section: Discussionsupporting

confidence: 89%

H₂S contributes to the hepatic arterial buffer response and mediates vasorelaxation of the hepatic artery via activation of K_ATP channels

Siebert¹,

Cantré²,

Eipel³

et al. 2008

American Journal of Physiology-Gastrointestinal and Liver Physi

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“…The latter substance has even been suggested to be permissive for the high basal islet blood perfusion (30). In a previous study we found that administration of arginine did not influence islet blood flow in itself, suggesting that substrate supply is not normally limiting for NO effects in the islets (33), which also confirms findings in other organs (11). In the present study, we used a dose of arginase which in other studies has decreased serum arginine concentrations (12,13).…”

Section: Discussionsupporting

confidence: 86%

“…Theoretically it could be assumed that this would impair the flow through vascular beds mainly regulated by NO through substrate depletion (10). However, administration of arginase to pigs (9) or rats (11,12) did not affect blood perfusion in most vascular beds. Indeed, in one study a paradoxical increase in intestinal, ventricular, splenic and liver blood flow was observed (13).…”

Section: Introductionmentioning

confidence: 99%

Arginase Increases Total Pancreatic and Islet Blood Flow in Anaesthetized Mice

Jansson

Bodin

Källskog

2007

Upsala Journal of Medical Sciences

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Background. Previous studies have demonstrated that the high basal pancreatic islet blood perfusion is crucially dependent on nitric oxide formation. Arginase can interfere with the formation of nitric oxide by limiting substrate availability. The aim of the present study was to evaluate the influence of arginase on islet blood perfusion in anasthetized mice.Methods. The blood perfusion of the pancreatic islets was measured with a microsphere technique in anaesthetized NMRI mice after administration of arginase.Results: Arginase administration increased both total pancreatic and islet blood flow to the same degree. Also adrenal blood flow was increased, whereas other organ blood flow values were unaffected.Conclusion. Arginase induces a paradoxical increase in pancreatic and islet blood flow, the reasons for which are still unknown.

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“…Of these articles, 52 (38.0%) showed a decreased RVR [25, 28, 30, 31, 32, 33, 34, 36, 45, 46, 47, 51, 52, 53, 58, 62, 63, 68, 69, 70, 71, 72, 73, 74, 75, 78, 84, 85, 87, 92, 95, 98, 99, 100, 101, 109, 111, 112, 114, 115, 120, 122, 124, 125, 126, 130, 131, 135, 143, 144, 154, 155], 16 (11.7%) an unchanged RVR [23, 29, 35, 37, 60, 64, 80, 97, 106, 108, 110, 113, 116, 119, 140, 145,] and 69 (50.3%) an increased RVR [20, 21, 22, 24, 26, 27, 38, 39, 40, 41, 42, 43, 44, 48, 49, 50, 54, 55, 56, 57, 59, 61, 65, …”

Section: Resultsmentioning

confidence: 99%

Renal Vascular Resistance in Sepsis

et al. 2006

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Aims: To assess changes in renal vascular resistance (RVR) in human and experimental sepsis and to identify determinants of RVR. Methods: We performed a systematic interrogation of two electronic reference libraries using specific search terms. Subjects were animals and patients involved in experimental and human studies of sepsis and septic acute renal failure, in which the RVR was assessed. We obtained all human and experimental articles reporting RVR during sepsis. We assessed the role of various factors that might influence the RVR during sepsis using statistical methods. Results: We found no human studies, in which the renal blood flow (and, therefore, the RVR) was measured with suitably accurate direct methods. Of the 137 animal studies identified, 52 reported a decreased RVR, 16 studies reported no change in RVR, and 69 studies reported an increased RVR. Consciousness of animals, duration of measurement, method of induction of sepsis, and fluid administration had no effect on the RVR. On the other hand, on univariate analysis, size of the animals (p<0.001), technique of measurement (p = 0.017), recovery after surgery (p = 0.004), and cardiac output (p <0.001) influenced the RVR. Multivariate analysis, however, showed that only cardiac output (p = 0.028) and size of the animals (p = 0.031) remained independent determinants of the RVR. Conclusions: Changes in RVR during sepsis in humans are unknown. In experimental sepsis, several factors not directly related to sepsis per se appear to influence the RVR. A high cardiac output and the use of large animals predict a decreased RVR, while a decreased cardiac output and the use of small animals predict an increased RVR.

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The effect of mild endotoxemia during low arginine plasma levels on organ blood flow in rats

Abstract: The present study shows that low arginine plasma levels do not influence organ blood flow, whereas, during a low-grade endotoxemia, low arginine plasma levels result in reduced blood flow to the small intestine.

Cited by 23 publications

References 25 publications

H₂S contributes to the hepatic arterial buffer response and mediates vasorelaxation of the hepatic artery via activation of K_ATP channels

H₂S contributes to the hepatic arterial buffer response and mediates vasorelaxation of the hepatic artery via activation of K_ATP channels

Arginase Increases Total Pancreatic and Islet Blood Flow in Anaesthetized Mice

Renal Vascular Resistance in Sepsis

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The effect of mild endotoxemia during low arginine plasma levels on organ blood flow in rats

Abstract: The present study shows that low arginine plasma levels do not influence organ blood flow, whereas, during a low-grade endotoxemia, low arginine plasma levels result in reduced blood flow to the small intestine.

Cited by 23 publications

References 25 publications

H2S contributes to the hepatic arterial buffer response and mediates vasorelaxation of the hepatic artery via activation of KATP channels

H2S contributes to the hepatic arterial buffer response and mediates vasorelaxation of the hepatic artery via activation of KATP channels

Arginase Increases Total Pancreatic and Islet Blood Flow in Anaesthetized Mice

Renal Vascular Resistance in Sepsis

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Product

Resources

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H₂S contributes to the hepatic arterial buffer response and mediates vasorelaxation of the hepatic artery via activation of K_ATP channels

H₂S contributes to the hepatic arterial buffer response and mediates vasorelaxation of the hepatic artery via activation of K_ATP channels