The Effect of Microwave on Y-Maze Learning in the White Rat

Neolelgh, Roger C.; Garner, R.J.; Morgont, R. John; Crosstt, Henry A.; Lambert, Paul D.

doi:10.1080/00222739.1971.11688779

Cited by 10 publications

(2 citation statements)

References 3 publications

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“…There are at least three reports in the literature (Justesen & King, 1970;Lebovitz, 1981;Nealeigh, Garner, Morgan, Cross, & Lambert, 1971) of a qualitative increase in efficiency of performance (i. e., a reduction in errors involving performance of discrimination) by rats under moderate ('\, 1 0 C) microwave-induced elevations of core temperature. The P300 data of the present study answer only the quantitative question regarding the dependence on brain temperature of the time rate at which cognition is achieved.…”

Section: Dependent Measuresmentioning

confidence: 99%

Endogenous hyperthermia in normal human subjects: I. Experimental study of evoked potentials and reaction time

et al. 1985

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Previous work on awake guinea pigs and rats in the authors' laboratory revealed that microwaveinduced elevations of brain temperature (.:lTs from 1 0 to 3 0 C over resting baselines) are associated with reliable reductions in latencies of flash-evoked brain potentials' (EPs). To assess the generality of this finding in the normal human being, and to avoid the ethical problem of whole-body human exposure to an intense microwave field, .:lTs were induced endogenously by vigorous exercise and by insulative and vapor-barrier clothing. Twenty male athletes, 18 to 22 years of age, were randomly but equally divided into counterbalanced experimental and control groups for a single 3-h morning or afternoon session of measurements. During baseline measures, EPs of three types were observed: flash-evoked N1, pattern-reversal P100, and event-related P300. In addition, simple reaction times (RTs) to photic stimulation were recorded. All measures were repeated after sham warming of the 10 control subjects and after tympanically indexed brain temperatures of the 10 experimental subjects were elevated by an average of 1.2 0 C above control values. EP and RT latencies were reliably reduced in association with the .:lTs, the mean reductions ranging from 3% to 9%. The data on the human flash-evoked N1 component compare favorably with data recorded from rats and guinea pigs that have undergone exogenous elevations of temperature by microwave irradiation. The data on RTs and other EP components are consistent with the thesis that human CNS activity in general is accelerated during a modest bout of whole-body hyperthermia.More than half a century has passed since Hoagland hypothesized that elevation of brain temperature is associated with acceleration of catalytic events that may represent the rate-limiting step in biochemical reactions (Hoagland, 1933). The predicted result is an increase in propagation velocity of nerve impulses. Earlier and sub-

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Section: Dependent Measuresmentioning

confidence: 99%

Endogenous hyperthermia in normal human subjects: I. Experimental study of evoked potentials and reaction time

et al. 1985

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“…We believe that elevations of rectal temperature to levels near 40 øC, with commensurate ,aTs of brain temperatures, which can occur endogenously during the metabolic hyperarousal of fight, flight, or threat, may play an adaptive role because of heightened activity of the nervous system [cf. Justesen and King, 1970and Justesen and Bruce-Wolfe, 1977, with Nealeigh et al, 1971]. Beyond 40 øC, the likelihood of adaptive facilitation seems less likely, at least in human beings, given the epileptiform activity and hallucinatory episodes that attend intense fevers.…”

Section: Interpretation Of Our Findings Must Be Tempered By Thementioning

confidence: 99%

Microwave‐induced hyperthermia and the visually evoked electrocortical response of the guinea pig

Bruce‐Wolfe¹,

Justesen²

1979

Radio Science

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Five experimentally naive female guinea pigs, all young adults, were observed during a succession of 11 experiments for visually evoked electrocortical responses (VERs). In each experiment, VERs were recorded within minutes after an animal had received a hyperthermalizing dose of microwave radiation in a 2450-MHz field. Latency of the N• component of the VER, an inverse index of conduction velocity of primary visual fibers, was recorded via an electroencephalograph on a signal-averaging computer. Cortical and rectal temperatures were observed and recorded during measurement of VERs. The mean latency from onset of photic stimulation to the N• peak diminished from 42.8 to 37.7 ms at respective cortical temperatures of 37.0 and 40.5 øC, which represents a mean increase of conduction velocity of 3.4 percent per incremented Celsius degree. While cortical and rectal temperatures were highly correlated, the former were invariably lower by nearly 2 øC, although they diverged slightly at higher elevations. Above a cortical temperature of 41.5 øC, evidence of reversible and irreversible thermal toxicity was observed.

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Behavioural Effects of Radiofrequency Energy

Servantie

Gillard

1983

Biological Effects and Dosimetry of Nonionizing Radiation

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The Effect of Microwave on Y-Maze Learning in the White Rat

Cited by 10 publications

References 3 publications

Endogenous hyperthermia in normal human subjects: I. Experimental study of evoked potentials and reaction time

Endogenous hyperthermia in normal human subjects: I. Experimental study of evoked potentials and reaction time

Microwave‐induced hyperthermia and the visually evoked electrocortical response of the guinea pig

Behavioural Effects of Radiofrequency Energy

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