The effect of micronutrient supplementation on quality-of-life and left ventricular function in elderly patients with chronic heart failure

Witte, Klaus K.; Nikitin, Nikolay P.; Parker, A C; Haehling, Stephan von; Volk, Hans‐Dieter; Anker, Stefan D.; Clark, Andrew L.; Cleland, John G.F.

doi:10.1093/eurheartj/ehi442

Cited by 271 publications

(230 citation statements)

References 43 publications

Supporting

Mentioning

213

Contrasting

Unclassified

Order By: Relevance

“…Witte et al presented data indicating that supplementation with micronutrients including selenium and coenzyme Q10 could improve cardiac left ventricular (LV) function according to evaluations made using cardiac magnetic resonance scans [59]. The authors also demonstrated a significant increase in quality of life as evaluated by the EuroQoL inventory (a European multidisciplinary inventory to evaluate the health status), but at the same time no change of the NYHA (New York Heart Association) functional class could be reported.…”

Section: Selenium and Coenzyme Q10 In Heart Diseasementioning

confidence: 99%

Selenium and coenzyme Q10 interrelationship in cardiovascular diseases – A clinician's point of view

Alehagen

Aaseth

2015

Journal of Trace Elements in Medicine and Biology

View full text Add to dashboard Cite

show abstract

Section: Selenium and Coenzyme Q10 In Heart Diseasementioning

confidence: 99%

Selenium and coenzyme Q10 interrelationship in cardiovascular diseases – A clinician's point of view

Alehagen

Aaseth

2015

Journal of Trace Elements in Medicine and Biology

View full text Add to dashboard Cite

show abstract

“…Although the regression of cardiac hypertrophy by dietary copper supplementation in humans is unknown, a recent study in a small population of chronic heart failure patients has shown that dietary supplementation with micronutrients for 9 months increased left ventricle ejection, decreased left ventricle volume, and improved the quality of life [2]. Among the formulated micronutrients was Cu (1.2 mg/day), which has been considered to play an important role in the improvement of cardiac function [3].…”

Section: Introductionmentioning

confidence: 99%

Copper reverses cardiomyocyte hypertrophy through vascular endothelial growth factor-mediated reduction in the cell size

Zhou

Jiang

Kang

2008

Journal of Molecular and Cellular Cardiology

View full text Add to dashboard Cite

Previous studies have shown that dietary copper supplementation reversed heart hypertrophy induced by pressure overload in a mouse model. The present study was undertaken to understand the cellular basis of copper-induced regression of cardiac hypertrophy. Primary cultures of neonatal rat cardiomyocytes were treated with phenylephrine at a final concentration of 100 μM in cultures for 48 h to induce cellular hypertrophy. The hypertrophied cardiomyocytes were exposed to copper sulfate at a final concentration of 5 μM in cultures for additional 24 h. This copper treatment reduced the size of the hypertrophied cardiomyocytes, as measured by flow cytometry, protein content in cells, cell volume and cardiomyocyte hypertrophy markers including beta myosin heavy chain protein, skeletal alpha-actin, and atrial natriuretic peptide. Cell cycle analysis and cell sorting of p-histone-3 labeled cardiomyocytes indicated that cell division was not involved in the copper-induced regression of cardiomyocyte hypertrophy. Copper also inhibited PE-induced apoptosis, determined by a TUNEL assay. Because copper stimulates vascular endothelial growth factor (VEGF) production through activation of hypoxia-inducible transcription factor, an anti-VEGF antibody at a final concentration of 2 ng/ml in cultures was used and shown to blunt copper-induced regression of cell hypertrophy. Conversely, VEGF alone at a final concentration of 0.2 μg/ml reversed cell hypertrophy as the same as copper did. This study demonstrates that both copper and VEGF reduce the size of hypertrophied cardiomyocytes, and copper regression of cardiac hypertrophy is VEGF dependent.

show abstract

“…We were able to relate increasing levels of isoprostanes and reduced antioxidant concentrations to increasing NYHA functional class. In a previous study, multiple micronutrient supplementation, including the antioxidant vitamins C and E, improved left ventricular function and quality-of-life scores in a small group of elderly patients with CHF [31]. In contrast, antioxidant supplementation with vitamin E (a-tocopherol) alone did not help patients with CHF [32] and may even be harmful [33].…”

Section: Discussionmentioning

confidence: 89%

Nutritional intake and oxidative stress in chronic heart failure

Hughes

Woodside

McGartland

et al. 2012

Nutrition, Metabolism and Cardiovascular Diseases

View full text Add to dashboard Cite

Background and aims: Patients with chronic heart failure (CHF) are known to be at risk of malnutrition, and cardiac cachexia is an adverse prognostic indicator. The aim of this study was to determine the dietary adequacy of CHF patients compared with Dietary Reference Values, to compare the nutritional intake and status of CHF patients to a healthy comparison group, and finally to determine whether nutritional intake and status depended on New York Heart Association (NYHA) functional class. Methods and Results: Patients with CHF (n Z 39) and a comparison group of 27 healthy participants, who did not have CHF, were asked to complete a four-day food diary, and energy and nutrient intakes were calculated. F 2a -isoprostanes were measured in urine as an indicator of oxidative stress and antioxidants were measured in serum or plasma. Overall 73% of the CHF patients were consuming less than recommended energy intakes, and more than 50% of these patients were also consuming less than recommended vitamin D, selenium and zinc intakes. Nutrient intake (energy, vitamin B6, D, E, iron, folate and riboflavin) was lower in CHF patients than in the comparison group, with vitamin B6 and folate intake and antioxidant status decreasing, and isoprostane status increasing as NYHA functional class increased. Conclusion: The majority of CHF patients do not meet dietary reference values for energy and a range of nutrients, and nutrient intake is lower in CHF patients than in healthy individuals. Dietary inadequacy tends to be increased in those with more severe disease. ª

show abstract

The effect of micronutrient supplementation on quality-of-life and left ventricular function in elderly patients with chronic heart failure

Abstract: Long-term multiple micronutrient supplementation can improve LV volumes and LVEF and QoL scores in elderly patients with heart failure due to LV systolic dysfunction.

Cited by 271 publications

References 43 publications

Selenium and coenzyme Q10 interrelationship in cardiovascular diseases – A clinician's point of view

Selenium and coenzyme Q10 interrelationship in cardiovascular diseases – A clinician's point of view

Copper reverses cardiomyocyte hypertrophy through vascular endothelial growth factor-mediated reduction in the cell size

Nutritional intake and oxidative stress in chronic heart failure

Contact Info

Product

Resources

About