The effect of metritis on luteal function in dairy cows

Strüve, Klaas; Herzog, Kathrin; Magata, Fumie; Marion, P; Shirasuna, Koumei; Miyamoto, Akio; Bollwein, Heinrich

doi:10.1186/1746-6148-9-244

Cited by 28 publications

(21 citation statements)

References 47 publications

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“…Dietary energy restriction may decrease IGF-I concentrations, causing altered follicular growth and development of a subfunctional CL (Burns et al 1997). In addition, metritis was able to impair luteal activity transiently, but did not seem to have a long-term effect on luteal function (Struve et al 2013). Moreover, the luteal phase and the length of the interovulatory interval were both shorter in heifers with two waves of follicular development compared to those with three (Ginther et al 1989).…”

Section: Discussionmentioning

confidence: 88%

Effects of season on plasma progesterone profiles in repeat breeding cows

Ghanem¹,

Nishibori²

2015

Vet. Med. - Czech

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Forty six Holstein Friesian repeat breeding cows (the average AI/conception was 5.2 ± 0.2) were investigated using the progesterone assay after AI to determine possible differences in plasma progesterone profiles between summer and winter seasons. Twenty eight (60.9%) and 18 (39.1%) cows were followed in summer (June-August) and winter (December-February), respectively. In the summer season, the total progesterone concentrations were higher (P < 0.05) in pregnant cows with normal luteal function compared to those in non-pregnant animals with abnormal luteal function. In contrast, in the winter season, there was no difference (P = 0.12) in total progesterone concentrations between pregnant and non-pregnant cows with normal or abnormal luteal functions. When the progesterone concentrations were compared, the pregnant and non-pregnant cows with normal luteal functions exhibited no difference (P = 0.92) in summer and winter seasons. Thus, the present study indicates that there is no effect of season on plasma progesterone profiles in repeat breeding cows; however in the summer season, the total progesterone concentrations were considerably higher in pregnant cows with normal luteal function compared to non-pregnant cows with abnormal luteal function.

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Section: Discussionmentioning

confidence: 88%

Effects of season on plasma progesterone profiles in repeat breeding cows

Ghanem¹,

Nishibori²

2015

Vet. Med. - Czech

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“…Metritis cows are 11 times more at risk of prolonged luteal cycles during the postpartum period [8]. One study reported that cows with metritis showed a higher prevalence of persistent corpus luteum (CL) during the first postpartum luteal phase compared to healthy cows [10]. Moreover, cows with clinical endometritis are more likely to show anovulatory anestrus after calving or prolonged luteal phases compared to normal animals [1,8].…”

Section: Introductionmentioning

confidence: 99%

Lipopolysaccharide-induced mechanisms of ovarian dysfunction in cows with uterine inflammatory diseases

Magata

2020

J. Reprod. Dev.

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Uterine inflammatory diseases commonly occur in postpartum dairy cows, resulting in reduced reproductive performance due to aberrant uterine and ovarian activity. Infection of the uterus with gram-negative bacteria results in the detection of lipopolysaccharide (LPS) in the plasma and follicular fluid of cows along with uterine inflammation. LPS acts on follicular components such as theca cells, granulosa cells, and follicle-enclosed oocytes, leading to impaired follicular activity. Follicles with a high LPS environment exhibit reduced follicular steroidogenesis due to the inhibition of steroidogenic enzyme transcription. Primary cell cultures of bovine granulosa and theca cells have shown that LPS acts on follicular cells to impair steroid production, which may disturb follicle growth and/or reduce their ability to ovulate. Even if ovulation occurs, cows with uterine inflammation are less likely to conceive because in addition to uterine damage, LPS also impairs the developmental competence of oocytes. LPS perturbs the nuclear and cytoplasmic maturation of bovine oocytes. Moreover, oocytes matured in an LPS treatment are less likely to develop into the blastocyst stage. Such oocytes also have a reduced number of trophoblast cells in blastocysts. Therefore, the detrimental effects of LPS on ovarian activity may be partly responsible for infertility in cows with uterine inflammation. Novel treatment and prevention strategies for uterine inflammatory diseases can be developed by advancing our knowledge of the pathophysiology underlying ovarian dysfunction, and this can only be achieved by further research. The present review outlines the molecular pathogenesis of LPS-induced ovarian dysfunction.

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“…(). It was also reported that cows with severe bacterial metritis had smaller CL and lower levels of circulatory P 4 (Struve et al., ; Williams et al., ). In the present study, lower luteal P 4 (μg/g of CL) in the buffaloes with cytological and purulent endometritis might be due to the adverse effect of infection on the development of pre‐ovulatory follicle or growth of CL (Sheldon, Cronin, Goeetze, Donofrio, & Schuberth, ; Williams et al., ).…”

Section: Discussionmentioning

confidence: 92%

Relationship between endometritis and oxidative stress in the follicular fluid and luteal function in the buffalo

Behera

Sharma

Singh

et al. 2016

Reprod Domestic Animals

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In this study, alteration in the follicular fluid composition and luteal function was investigated in the buffalo with endometritis. Genitalia were classified into cytological and purulent endometritis on the basis of polymorphonuclear cell cut off while non-endometritis served as control (n = 10/group). In the follicular phase, the number of surface follicles was counted, diameter of the largest follicle was measured and the follicular fluid was assayed for total protein, cholesterol, malondialdehyde (MDA), total antioxidant capacity (TAC), oestradiol (E2 ) and progesterone (P4 ). The P4 content of corpus luteum during mid-luteal phase was estimated by radioimmunoassay. Ovaries from the follicular phase of oestrous cycle showed no significant difference in the total number of surface follicles, size of the largest follicle and volume of follicular fluid in the buffaloes with and without endometritis (p > .05). However, the antral fluid of the largest follicle from the genitalia of buffalo with cytological and purulent endometritis showed a significant decrease in the concentration of total protein, cholesterol, TAC and E2 and a significant increase in the concentration of MDA and P4 (p < .05). The results indicated that there is an association between endometritis and decreased ovarian function.

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The effect of metritis on luteal function in dairy cows

Cited by 28 publications

References 47 publications

Effects of season on plasma progesterone profiles in repeat breeding cows

Effects of season on plasma progesterone profiles in repeat breeding cows

Lipopolysaccharide-induced mechanisms of ovarian dysfunction in cows with uterine inflammatory diseases

Relationship between endometritis and oxidative stress in the follicular fluid and luteal function in the buffalo

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