The effect of metrazol on the susceptibility of rats to sound-induced seizures.

Karn, Harry W.; Lodowski, C. H.; Patton, R. A.

doi:10.1037/h0056076

Cited by 13 publications

(9 citation statements)

References 6 publications

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“…Patton (10); King, Karn and Patton (6); and Patton, Karn and King (11) have already shown that nutritional factors are important determiners of seizure sensitivity. Karn, Lodowski and Patton (5) have also demonstrated that injection of sub-convulsive doses of metrazol prior to testing markedly increases susceptibility.…”

Section: Discussionmentioning

confidence: 97%

Studies on the nutritional basis of abnormal behavior in albino rats. II. Further analysis of the effects of inanition and vitamin B1 on convulsive seizures.

Patton¹,

Karn²,

King³

1942

Journal of Comparative Psychology

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Section: Discussionmentioning

confidence: 97%

Studies on the nutritional basis of abnormal behavior in albino rats. II. Further analysis of the effects of inanition and vitamin B1 on convulsive seizures.

Patton¹,

Karn²,

King³

1942

Journal of Comparative Psychology

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“…In addition, during the 1920s and 1940s over a hundred pharmacological studies were published in different journals of psychology. Specifically, the effects of substances such as caffeine (Schilling;1921;Peterson & Carter, 1936;, tobacco (Meyer, 1923), alcohol (Peterson & Carter, 1936), cocaine (Fowler, 1940), nicotine (Humphrey, 1942), peyote (Fernberger, 1932), atropine (Peterson & Carter, 1936), sodium phenobarbital (Williams & O'Brien, 1937), benzedrine (Searle & Brown, 1938;Wentink, 1938), adrenalin (Wentink, 1938;Fowler, 1941), sodium amytal (Settlege, 1936), metrazol (Karn, Lodowski & Patton, 1941), picrotoxine (Tainter, 1943), ephedrine (Wentink, 1938), insulin (Wentink, 1938;Stellar, 1943), coramine (Turchioe, 1945), pregnenolone (McGinnies, 1947) or opioids (Simon & Eddy, 1935;Eddy & Ahrens, 1935), among others, were widely tested on a varied plethora of aspects in both animals and humans. Particularly important in those earlier years of psychopharmacology were the studies by psychologist Harry L. Hollingworth which are cited as a standard for psychopharmacological research (Benjamin, Rogers & Rosenbaum, 1991;Hollingworth, 1912b;Hollingworth & Poffenberger, 1920).…”

Section: Existingmentioning

confidence: 99%

A Bibliometric Analysis of Research in Psychopharmacology by Psychology Departments (1987–2007)

Portillo‐Salido¹

2010

Span. j. psychol.

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From the very outset of scientific Psychology, psychologists have shown interest for drugs and their effects on behavior. This has given rise to numerous contributions, mostly in the form of Psychopharmacology publications. The aim of this study was to quantitatively evaluate these contributions and compare them with other academic disciplines related to Psychopharmacology. Using the PubMed database, we retrieved information about articles from 15 journals included in the Pharmacology and Pharmacy category of the Journal Citation Reports database for a 21-year period (1987 to 2007). There were 37540 articles which about 52% were represented by 3 journals. About 70% of psychology publications were represented by 2 of these journals. Psychology departments accounted for the 11% of the published papers, which places Psychology third behind Psychiatry and Pharmacology, which contributed to 22.69 and 13% respectively. Psychology contributed to the greatest number of studies in 3 journals, second in 3 and third in 8. This report represents the first effort to explore the contribution of academic Psychology to the multidisciplinary science of psychopharmacology. Although leaders of production of psychopharmacology research were from Psychiatry and Pharmacology, Psychology departments are an important source of studies and thus of knowledge in the field of Psychopharmacology Desde los mismos inicios de la Psicología científica los psicólogos han mostrado interés por los fármacos y el efecto de éstos sobre la conducta. Esto ha dado lugar a numerosas aportaciones, principalmente en forma de publicaciones de Psicofarmacología. El objetivo de este estudio fue evaluar cuantitativamente estas aportaciones y compararlas con las de otras disciplinas académicas relacionadas con la Psicofarmacología. Usando la base de datos PubMed se extrajo información sobre artículos publicados en 15 revistas incluidas en la categoría de Farmacología y Farmacia de la base de datos Journal Citation Reports durante un período de 21 años . Hubo 37.540 artículos de los cuales alrededor del 52% se publicaron en 3 revistas. El 70 % de las publicaciones de psicología se publicaron en 2 de estas revistas. Psicología, con el 11% de los artículos publicados, fue la tercera detrás de Psiquiatría y Farmacología, que contribuyeron con el 22,69 y el 13% respectivamente. Psicología contribuyó con el mayor número de estudios en 3 revistas, fue la segunda en 3 y la tercera en 8. Este estudio representa un primer intento por explorar la contribución de la Psicología académica a la ciencia multidisciplinar de la psicofarmacología. Aunque los líderes de producción en investigación psicofarmacológica fueron Psiquiatría y Farmacología, los departamentos de Psicología son una importante fuente de estudios y por tanto de conocimiento en el campo de la Psicofarmacología.Palabras clave: psicología, psiquiatría, farmacología, psicofarmacología, revistas científicas, estudio bibliométrico.

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“…During the past six years many investigators have reported studies of a disorganized pattern of rat behavior variously termed experimental neurosis (19) or neurotic behavior (15), audiogenie seizure (6,11,14,22,25,29,31), audio-epileptic seizure (30), noisefright convulsion (32), sonogenic convulsion (23), sound-induced seizure (17). The diagnostic name preferred by a given writer has in general reflected his opinion of the fundamental nature of the behavior.…”

mentioning

confidence: 99%

“…The diagnostic name preferred by a given writer has in general reflected his opinion of the fundamental nature of the behavior. For example, 'experimental neurosis' has been coupled with a clash of incompatible response-tendencies (19); 'audiogenic seizure' and 'sound-induced seizure' are terms adopted by those emphasizing the auditory aspect of the precipitating situation (25,17); 'noise-fright convulsion' implies a strong emotional component in the complex of antecedent events (32). That agreement concerning the fundamental nature of the pattern has not yet been achieved is illustrated by several statements in a recent REVIEW article by M. E. Bitterman (3).…”

mentioning

confidence: 99%

“…(10). It appears, for example, that sub-convulsive doses of metrazol (17,21), 24-hour hunger (8), and vitamin deficiency (27), all increase the likelihood of seizure. But of all the thousands of rats serving as subject in many laboratories and under widely diverse conditions (including 'strong conflict'), only one rat is reported to have given the seizure pattern in the absence of intense sound (13).…”

mentioning

confidence: 99%

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