The Effect of Metoclopramide on the Lower Oesophageal Sphincter in Late Pregnancy

Abstract

The effects of intravenous metoclopramide (Maxolon) on the lower oesophageal sphincter (LOS) were studied in three groups of patients, one group being normal control and the other two being pregnant females, one without heartburn and the other with. Metoclopramide increases the LOS pressure 20•5,15•2 and 10•2cm HP respectively (P <0'005, p <0•005 and p <0•05). These findings suggest that for patients undergoing elective or emergency obstetrical anaesthesia, intravenous metoclopramide may help reduce the incidence of regurgitation of gastric contents.

Fetal heart rate decelerations during ECT‐induced seizures: is it important?

“…No lateral tilt was used. Before anesthesia induction, the patient received bicitra 30 ml per os and metoclopramide 10 mg i.v (3, 4). A blood pressure cuff was employed as a tourniquet to monitor motor activity.…”

Preanaesthetic management of the obstetric patient

“…Metoc1opramide, a dopamine antagonist, promotes gastric emptying in the pregnant women dur-992 ing labour (19), raises the lower oesophageal sphincter tone, and has antiemetic properties (20). However, it may not reverse the delayed gastric emptying associated with opioid administration (5).…”

“…However, it may not reverse the delayed gastric emptying associated with opioid administration (5). Furthermore, anticholinergics, such as atropine and glycopyrrolate, block its effects on the gut (20). Metoclopramide crosses the placenta, but has no adverse effects on the neurobehavioural scores (21).…”

Medikamentöse Prophylaxe des Säureaspirationssyndroms

“…Darüber hinaus erschwert Metoclopramid über die Erhöhung des distalen Ösophagussphinktertonus die retrograde Magenentleerung (7,67). Metoclopramid antagonisiert auch den tonusmindernden Effekt von Anticholinergika (9).…”