The effect of metoclopramide on gastric emptying in traumatic brain injury

Bedside postpyloric feeding tube placement: A pilot series to validate this novel technique

“…It highlights the need to regularly reappraise the need for adjuvant nutritional support by means of nasoenteral tubes as these are distressing to patients. Metaclopramide was used in all patients, with no adverse complications associated with its use in agreement with other reported studies, even though its value remains somewhat contentious (6,15,16).…”

Guidelines for the Provision and Assessment of Nutrition Support Therapy in the Adult Critically Ill Patient

“…Rationale: Adding prokinetic agents such as erythromycin or metoclopramide has been shown to improve gastric emptying and tolerance of EN but has resulted in little change in clinical outcome for ICU patients. A total of 8 RCTs that met our inclusion criteria 130 ‐ 137 using metoclopramide and 1 combining erythromycin with metoclopramide were reviewed by meta‐analysis. No difference was found in terms of mortality or infection.…”

ASPEN Safe Practices for Enteral Nutrition Therapy

“…A total of 8 randomized controlled trials using metoclopramide and 1 trial combining erythromycin with metoclopramide were reviewed by meta‐analysis. The use of prokinetic agents was not found to make a difference in terms of mortality or infection 42 . ‐ 49 Erythromycin has been associated with undesirable effects, including cardiac toxicity, tachyphylaxis, and bacterial resistance, and should be used cautiously with monitoring.…”