The Effect of Methylphenidate on the Microstructure of Schedule-Induced Polydipsia in an animal model of ADHD

Íbias, Javier; Daniels, Carter W.; Miguéns, Miguel; Pellón, Ricardo; Sanabria, Federico

doi:10.1016/j.bbr.2017.06.048

Behavioural Brain Research

2017

DOI: 10.1016/j.bbr.2017.06.048

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The Effect of Methylphenidate on the Microstructure of Schedule-Induced Polydipsia in an animal model of ADHD

Javier Íbias

Carter W. Daniels

Miguel Miguéns

et al.

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Cited by 5 publications

(3 citation statements)

References 41 publications

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“…23,24 For instance, SHR rats display similar licking rates in SIP under fixed time 60 seconds (FT-60 seconds) and 30 seconds schedules of reinforcement when compared with WIST rats, even although SHR rats show poorer performance in a delay-discounting task. 24 Similarly, SIP microstructural measures could be useful tools to model aspects of compulsivity. 24 Similarly, SIP microstructural measures could be useful tools to model aspects of compulsivity.…”

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confidence: 99%

“…6,12 However, recent studies have pointed toward the importance of analyzing the pattern of licking using microstructural measures to better identify deficits in inhibitory control. 23,24 For instance, SHR rats display similar licking rates in SIP under fixed time 60 seconds (FT-60 seconds) and 30 seconds schedules of reinforcement when compared with WIST rats, even although SHR rats show poorer performance in a delay-discounting task. 21 When comparing microstructural measures in SIP between SHR and WIST rats, SHR rats show an increased proportion of trials with drinking bouts and a higher number of drinking bouts of shorter duration per drinking episode, indicating a hyperactive-like pattern of licking.…”

mentioning

confidence: 99%

“…21 When comparing microstructural measures in SIP between SHR and WIST rats, SHR rats show an increased proportion of trials with drinking bouts and a higher number of drinking bouts of shorter duration per drinking episode, indicating a hyperactive-like pattern of licking. 24 Similarly, SIP microstructural measures could be useful tools to model aspects of compulsivity.…”

mentioning

confidence: 99%

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Excessive habit formation in schedule‐induced polydipsia: Microstructural analysis of licking among rat strains and involvement of the orbitofrontal cortex

Merchán

Mora

Gago

et al. 2018

Genes Brain and Behavior

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Schedule-induced polydipsia (SIP) is an animal model of compulsive drinking that selects for individual differences and varies across rat strains. The aim of this study was to investigate excessive habit formation by analyzing the SIP licking microstructure among rat strains, and to compare the brain areas activated by SIP in different populations. Wistar, Long Evans and Roman High- and Low-Avoidance rat strains were compared using a cluster analysis of 2 main variables, that is, frequency of licking (percentage of interpellet intervals with drinking episodes) and intensity of licking (mean number of licks per interpellet interval), and were found to exhibit high intensity and frequent licking (compulsive drinkers, CD), low intensity but frequent licking (habitual drinkers, HD), and low intensity and low-frequency licking (low drinkers, LD). The Wistar strain showed a higher frequency and intensity of licking, and had the largest group of CD rats when compared with the other strains. Regarding the acquisition of SIP, CD rats showed a higher intensity of licking when compared with the HD and LD rats. Moreover, c-Fos quantification revealed that rats in the CD group showed hyperactivity in the lateral orbitofrontal cortex and basolateral amygdala when compared with the LD group. Analyzing the SIP microstructure could be a valuable tool for understanding the role of excessive habit formation in the development of compulsive drinking and its underpinning neurobiological mechanisms.

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confidence: 99%

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confidence: 99%

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confidence: 99%

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Excessive habit formation in schedule‐induced polydipsia: Microstructural analysis of licking among rat strains and involvement of the orbitofrontal cortex

Merchán

Mora

Gago

et al. 2018

Genes Brain and Behavior

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Repeated Δ-9-Tetrahydrocannabinol administration dose dependently increases stablished schedule-induced drinking

Fuentes-Verdugo,

Pellón,

Miguéns

2024

Psychopharmacology

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Rationale Schedule-induced drinking (SID) reproduces an excessive and repetitive behavioural pattern that has led to propose this procedure as an animal model to study compulsive behaviours. Although it is known that cannabis can cause several adverse effects, in recent years there has been great interest in the medical application of cannabis derivatives for obsessive-compulsive related disorders. Objectives The present study investigated the effects of repeated THC administration on rates of previously acquired SID, as well as the possible alteration of its temporal distribution along inter-food intervals. Methods Male Wistar rats acquired SID under a 30 min fixed-time 30-sec food delivery schedule (from 30 to 43 sessions to reach a stable level). Thereafter, 5 or 10 mg/kg daily i.p. injections of THC or vehicle were repeatedly administered for 7 days to evaluate the effects on SID. Results Repeated THC administration at a dose of 5 mg/kg resulted in an increase on licking. Surprisingly, no effects on SID were observed with the 10 mg/kg dose. However, magazine entries were reduced with both THC doses. THC also modified the temporal distributions of licking and magazine entries during inter-food intervals. Conclusions The present results show that repeated THC administration may (i) increase induced licking at moderate doses, (ii) reduce magazine entries, and (iii) affect the temporal pattern of SID. These findings suggest that THC does not appear to be beneficial to reduce compulsive behaviour in this animal model, while another collateral effect of THC —such as a greater habitual-like behaviour— needs to be considered.

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A computational formulation of the behavior systems account of the temporal organization of motivated behavior

Sanabria

Daniels

Gupta

et al. 2019

Behavioural Processes

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The Effect of Methylphenidate on the Microstructure of Schedule-Induced Polydipsia in an animal model of ADHD

Cited by 5 publications

References 41 publications

Excessive habit formation in schedule‐induced polydipsia: Microstructural analysis of licking among rat strains and involvement of the orbitofrontal cortex

Excessive habit formation in schedule‐induced polydipsia: Microstructural analysis of licking among rat strains and involvement of the orbitofrontal cortex

Repeated Δ-9-Tetrahydrocannabinol administration dose dependently increases stablished schedule-induced drinking

A computational formulation of the behavior systems account of the temporal organization of motivated behavior

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