The effect of methylethylpiridinol addition to the therapy on the level of pigment epithelium-derived factor and oxidative status in patients with diabetic nephropathy: randomized controlled open-label clinical study

Попов, С. С.; Ануфриева, Е. И.; Крыльский, Е. Д.; Shulgin, K. K.; Веревкин, А.Н.; Popova, T. N.; Пашков, А. Н.

doi:10.1007/s40200-021-00802-6

Cited by 4 publications

(2 citation statements)

References 29 publications

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“…The dominant disease of TCM means that there is no good treatment method or curative effect in western medicine at present, but TCM can be treated with a definite curative effect, or the curative effect of traditional Chinese and western medicine is definite, but the adverse reactions of TCM are relatively few, which is not easy to bring about drug-induced and iatrogenic diseases [ 26 – 28 ]. TCM has many advantages in the treatment of “eliminating thirst nephropathy,” which has been continuously optimized on the basis of summing up clinical experience for many years.…”

Section: Discussionmentioning

confidence: 99%

Clinical Application of the Classical Theory of Traditional Chinese Medicine in Diabetic Nephropathy

Pan

Shi

2022

Computational and Mathematical Methods in Medicine

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Objective. To explore the clinical application of the classical theory of traditional Chinese medicine (TCM) in diabetic nephropathy (DN). Methods. A total of 100 patients with DN treated in our hospital from May 2019 to June 2021 were included. The patients were randomly assigned to the control group and the study group. The control group received routine treatment, and the study group was treated with the classical theory of TCM. The efficacy, TCM syndrome score, urine proteinuria (UTP), urine albumin-creatinine ratio (UACR), plasma albumin (ALB), hemoglobin A1c (HbA1C), fasting blood glucose (FBG), blood urea nitrogen (BUN), creatinine (Cr), and treatment safety were compared between the two groups. Results. In comparison to the curative effect, the study group was significantly effective in 34 cases, effective in 12 cases, and ineffective in 4 cases, and the effective rate was 92.00%; the control group was significantly effective in 16 cases, effective in 18 cases, and ineffective in 16 cases, and the effective rate was 68.00%. The effective rate in the study group was higher compared to the control ( P < 0.05 ). In comparison to the TCM syndrome scores, there exhibited no significant difference before treatment ( P > 0.05 ), but after treatment, the TCM syndrome scores of the two groups decreased, and the TCM syndrome scores of the study group were lower compared to the control at 6 weeks, 12 weeks, 24 weeks, and 36 weeks of treatment ( P < 0.05 ). There exhibited no significant difference in the indexes of UTP and UACR before treatment, but the indexes of UTP and UACR in the two groups decreased after treatment, and the indexes of UTP and UACR in the study group were lower compared to the control at 6 and 12 weeks after treatment. There was no significant difference in the indexes of ALB, HbA1C, and FBG before treatment, but after treatment, the indexes of ALB increased, the indexes of HbA1C and FBG decreased in both groups, and the indexes of HbA1C and FBG i4n the study group were lower compared to the control, while the index of ALB in the study group was higher. The indexes of BUN and Cr were compared, and there was no significant difference before treatment, but after treatment, the indexes of BUN and Cr in the two groups decreased, and the indexes of BUN and Cr in the study group were lower compared to the control ( P < 0.05 ). In terms of the treatment safety of the two groups, there was no abnormality in blood, urine, stool routine, and liver and kidney function examination in the study group. No obvious adverse reactions were found in all patients. There were 1 case of abnormal liver function and 2 cases of rash in the control group, and there exhibited no significant difference ( P > 0.05 ). Conclusion. Under the guidance of classical theory, the optimization scheme of comprehensive treatment of TCM may improve renal function by improving metabolic disorders, vascular lesions, neurotrophic disorders, antioxidant stress, and other ways to repair nerve injury, improving the changes of TCM syndromes, signs, and indicators of patients, and delay the progress of DN.

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Section: Discussionmentioning

confidence: 99%

Clinical Application of the Classical Theory of Traditional Chinese Medicine in Diabetic Nephropathy

Pan

Shi

2022

Computational and Mathematical Methods in Medicine

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“…Производное аминоурацила, аллацил, применялось в качестве мочегонного, снижающего реабсорбцию ионов натрия и в меньшей степени ионов хлора. В связи с появлением на фармацевтическом рынке более эффективных диуретических средств в настоящее время аллацил в медицинской практике не используется [55].…”

Section: другие виды фармакологической активностиunclassified

Review of Pyrimidine Derivatives as Pharmacologically Active Compounds

Chiriapkin

2022

Juvenis scientia

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Pyrimidine derivatives represent an extensive class of organic compounds that contain in their structure a six-membered heterocycle with two nitrogen atoms at positions 1 and 3. Substances of this group have a wide range of pharmacological activity, which makes it possible to consider the pyrimidine core as a promising scaffold for the development of new biologically active compounds. The article provides an analysis of the literature data of pyrimidine derivatives used in medical practice. For example, there are substances with antiviral, psychotropic, antimicrobial, antitumor, antifungal, antiparasitic and anabolic activity. Based on the structure-activity relationship of pyrimidine structures of active drugs, as well as other compounds that are considered candidates for the development of new drugs, it is possible to search for and design compounds with the desired types of pharmacological activity. Thus, a systematic analysis of pyrimidine derivatives from a pharmacological point of view can serve as a basis for further search for new highly effective and safe medicines.

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Analysis of the management and therapeutic performance of diabetes mellitus employing special target

Sun,

Lin

2023

World J Diabetes

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Diabetes mellitus (DM) is a chronic metabolic condition characterized predominantly by hyperglycemia. The most common causes contributing to the pathophysiology of diabetes are insufficient insulin secretion, resistance to insulin’s tissue-acting effects, or a combination of both. Over the last 30 years, the global prevalence of diabetes increased from 4% to 6.4%. If no better treatment or cure is found, this amount might climb to 430 million in the coming years. The major factors of the disease’s deterioration include age, obesity, and a sedentary lifestyle. Finding new therapies to manage diabetes safely and effectively without jeopardizing patient compliance has always been essential. Among the medications available to manage DM on this journey are glucagon-like peptide-1 agonists, thiazolidinediones, sulphonyl urease, glinides, biguanides, and insulin-targeting receptors discovered more than 10 years ago. Despite the extensive preliminary studies, a few clinical observations suggest this process is still in its early stages. The present review focuses on targets that contribute to insulin regulation and may be employed as targets in treating diabetes since they may be more efficient and secure than current and traditional treatments.

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The effect of methylethylpiridinol addition to the therapy on the level of pigment epithelium-derived factor and oxidative status in patients with diabetic nephropathy: randomized controlled open-label clinical study

Cited by 4 publications

References 29 publications

Clinical Application of the Classical Theory of Traditional Chinese Medicine in Diabetic Nephropathy

Clinical Application of the Classical Theory of Traditional Chinese Medicine in Diabetic Nephropathy

Review of Pyrimidine Derivatives as Pharmacologically Active Compounds

Analysis of the management and therapeutic performance of diabetes mellitus employing special target

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