The effect of methamphetamine on social interaction of adult male rats

Šlamberová, Romana; Mikulecká, Anna; Pometlová, Marie; Schutová, Barbora; Hrubá, Lenka; Deykun, Kateryna

doi:10.1016/j.bbr.2010.06.019

Cited by 37 publications

(20 citation statements)

References 36 publications

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“…These results are in agreement with findings showing increased activity only in animals with prenatal application of MA but not in controls in the open field test (Bubenikova-Valesova et al, 2009). However, in the test of social interaction there was increase of locomotion after single low-dose MA application (Pometlová et al, 2007;Slamberova et al, 2010). Therefore, manifestations of changes in general motor activity cased by single low-dose MA are dependent on the test environment.…”

Section: )supporting

confidence: 87%

“…The decrease of social interactions in the tests of social behavior of laboratory rats after the application of low doses of MA (0.5, 1.0 and 1.5 mg/kg) was described in our previous experimental works (Pometlová et al, 2007;Slamberova et al, 2010). This effect of MA was considered to be anxiogenic (File and Hyde, 1978).…”

Section: Introductionmentioning

confidence: 72%

“…In our previous work (Pometlová et al, 2008;Slamberova et al, 2010) the anxiogenic effect of MA was not confirmed either by presence of stretched attend posture or by changes in number of open arm entrances. These differences in our previous and present work are probably caused by more precise evaluation of EPM test findings by modified ethologic evaluation protocol.…”

Section: )mentioning

confidence: 78%

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Anxiogenic Effect of Low-dose Methamphetamine in the Test of Elevated Plus-maze

2012

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R e c e i ve d Fe b r u a r y 2 3 , 2 0 1 2 ; A c c e p t e d Ju n e 2 5 , 2 0 1 2 .Key words: Anxiety -Behavior -Elevated plus-maze -Methamphetamine Abstract: Methamphetamines (MA) are psychostimulant drugs that are known to change individuals' behavior. Psychostimulants could either evoke positive emotions (e.g. joy and happiness) or attenuate negative emotional states (e.g. anxiety and depression) in humans. In animal experiments, the test of elevated plus-maze (EPM) is widely used. This test is appropriate for evaluation of anxiolytic and anxiogenic drug effects, or for examination of specific subtypes of anxiety disorders. The aim of the present study was to examine the effect of acute single dose of MA (1 mg/kg) on the behavior of laboratory rat in the EPM. The detailed ethologic analysis of behavior was performed using a modified protocol based on the study of Fernández Espejo (1997). Our results demonstrated that MA affects rat's behavior in the EPM in the majority of analyzed categories. The present protocol allowed us to determine positive anxiogenic effect of MA.

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Section: )supporting

confidence: 87%

Section: Introductionmentioning

confidence: 72%

Section: )mentioning

confidence: 78%

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Anxiogenic Effect of Low-dose Methamphetamine in the Test of Elevated Plus-maze

2012

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“…In the EPM test, acute and chronic exposure to psychostimulants has been shown to have both anxiogenic [4,15,17,24,39] as well as anxiolytic effects [13,54]. In the SIT, psychostimulant drugs usually displayed anxiogenic effect in the form of decreased social interaction (SI) indicating increased anxiety [11,19,36,66], which was also observed in our previous studies [62,63] showing that MA administration impairs SI in dose-, stress condition-, and sexspecific manners. As far as the USV test is concerned, there are number of studies showing anxiolytic effects of psychostimulants on USVs in young animals [2,3,35,41], while withdrawal from the drug intake has the opposite, anxiogenic effect [12].…”

Section: Introductionsupporting

confidence: 59%

“…Forty-five minutes prior to testing, animals were injected with either a challenge dose of MA (1 mg/ml/kg) or saline (1 ml/kg). The dose of MA was chosen based on our previous studies [55,62] because this dose does not induce stereotypical behaviours. The timing of the drug application was also chosen based on our previous study [48] that showed that peak MA level in the brain (not in the blood) occurred between the 45th and 60th minute after administration.…”

Section: Animals and Drug Injectionsmentioning

confidence: 99%

Do the effects of prenatal exposure and acute treatment of methamphetamine on anxiety vary depending on the animal model used?

Šlamberová

Pometlová

Macúchová

et al. 2015

Behavioural Brain Research

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The effects of enriched environment on the behavioral and corticosterone response to methamphetamine in adolescent and adult mice

Baker

Magnuson

Dahly

et al. 2018

Developmental Psychobiology

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Methamphetamine alters behavior and the stress response system. Relatively little research has examined the effects of methamphetamine in adolescents and compared these effects to those in adults. Housing in enriched environments has been explored as one way to protect against the effects of methamphetamine, but the findings are conflicting and no study has examined how enriched environment may alter the behavioral and corticosterone responses to methamphetamine in adolescent and adult rodents. We examined the long-term effects of methamphetamine exposure on anxiety, social behavior, behavioral despair, and corticosterone levels in adolescent and adult mice housed in enriched or isolated environments. Enriched environment did not alter the behavioral or corticosterone response to methamphetamine. Methamphetamine exposure decreased anxiety and increased behavioral despair in adult mice, but methamphetamine did not alter behavior in adolescent mice. There was no effect of methamphetamine on social behavior or corticosterone levels. Our findings demonstrate that the specific environmental enrichment paradigm used in this study was not sufficient to mitigate the behavioral effects of methamphetamine and that adolescent mice are relatively resistant to the effects of methamphetamine compared to adult mice.

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The effect of methamphetamine on social interaction of adult male rats

Cited by 37 publications

References 36 publications

Anxiogenic Effect of Low-dose Methamphetamine in the Test of Elevated Plus-maze

Anxiogenic Effect of Low-dose Methamphetamine in the Test of Elevated Plus-maze

Do the effects of prenatal exposure and acute treatment of methamphetamine on anxiety vary depending on the animal model used?

The effects of enriched environment on the behavioral and corticosterone response to methamphetamine in adolescent and adult mice

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