The Effect of Metamucil on Postprandial Blood Glucose and Plasma Gastric Inhibitory Peptide in Insulin‐dependent Diabetics

Florholmen, Jon; Arvidsson-Lenner, Ragnhild; Jorde, Rolf; Burhol, P. G.

doi:10.1111/j.0954-6820.1982.tb03206.x

Cited by 28 publications

(2 citation statements)

References 15 publications

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“…However, these effects are predominantly observed in type II diabetics and with chronic consumption of psyllium. Other studies show variable effects of psyllium on blood glucose responses in normal and diabetic subjects ( 38 – 41 ) . The inconsistent results may be attributed to how psyllium is administrated and partly to the physical properties of the psyllium.…”

Section: Discussionmentioning

confidence: 95%

The acute effects of psyllium on postprandial lipaemia and thermogenesis in overweight and obese men

et al. 2008

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Overweight and obesity is one of the risk factors for developing CVD. At present, very little is known about the acute effects of dietary fibre on lipids, glucose and insulin, resting energy expenditure and diet-induced thermogenesis in overweight and obese individuals. This study examined the postprandial metabolic effects of dietary fibre in overweight and obese men. Ten overweight and obese men consumed a mixed meal accompanied by either a high-fibre or low-fibre supplement on two separate visits, in a random order, 1 week apart. Two isoenergetic breakfast meals with similar composition were consumed by ten overweight/obese men. The meals contained either a low (3 g) or high (15 g) amount of fibre, low-fibre meal (LFM) and high-fibre meal (HFM) respectively. Analysis was carried out using paired t test and ANOVA. Serum TAG incremental area under the curve during 6 h of the postprandial period was significantly lower after the consumption of HFM compared with LFM. At the first hour of the postprandial period, plasma apo B48 concentration after consumption of HFM was significantly lower compared with LFM. The resting energy expenditure and diet-induced thermogenesis after both meals was similar during 6 h of the postprandial period. Collectively, these findings suggest that a single acute dose of dietary fibre in the form of psyllium supplement can decrease arterial exposure to TAG and modify chylomicron responses in the postprandial period.Psyllium: Obesity: Postprandial state: Lipids: Lipoproteins: Thermogenesis Overweight and obesity is one of the important risk factors in the development of CVD. Atherosclerosis is the main cause of CVD. Several lipoprotein types probably contribute to the initiation of atherosclerosis, including LDL and chylomicron remnants (CMR) (1,2) . Under normal conditions, CMR are rapidly cleared from plasma predominantly via the LDLreceptor during the postprandial period. However, in the case of obesity, increased production and/or impaired clearance of these particles results in elevated plasma levels of postprandial chylomicrons and CMR (3) . Studies have also identified apo B48 as a marker of chylomicrons and CMR in femoral and carotid biopsies of human atherosclerotic plaque (4 -6) . Furthermore, studies have shown an increase in plasma CMR in subjects with or at risk of atherosclerosis (7,8) . As postprandial dyslipidaemia is an independent risk factor for atherosclerosis and CVD (8 -11) , this phenomenon may be an additional cause of rapid progress of atherosclerosis among overweight and obese individuals.Epidemiological studies have demonstrated that the prevalence of obesity is lower in populations that consume high-fibre diets compared with populations that consume low-fibre diets (12 -14) . Similarly, within population groups, individuals with a higher fibre intake tend to be leaner than individuals with a lower fibre intake and case-control studies have documented that obese individuals typically consume less fibre than normal-weight individuals (14 -16) . The main rat...

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Section: Discussionmentioning

confidence: 95%

The acute effects of psyllium on postprandial lipaemia and thermogenesis in overweight and obese men

et al. 2008

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“…SDF significantly decreased the postprandial plasma glucose in DM patients after 2 hours (mean reduction 14.2±5.2 vs 10.6±3.1 mmol/L). 7 In earlier research, it was found that psyllium decreased either the postprandial blood glucose concentrations 16 or the fasting plasma glucose level 8 in people with type 2 diabetes. In a different study, psyllium only had an effect on diabetic subjects' glycemic reaction to a test meal of flaked bran cereal when it was mixed into or sprinkled on top of the cereal.…”

Section: Discussionmentioning

confidence: 97%

The postprandial glucose-lowering effect of dietary fiber (Psyllium Husk) in patients with type 2 diabetes mellitus.

Muhammad Owais Fazal,

Ghulam Abbas,

Yasir Yaqoob

et al. 2024

TPMJ

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Objectives: To compare the mean reduction in postprandial plasma glucose in patients with diabetes mellitus type 2 by dietary fibre (psyllium husk) to those not using dietary fibre (psyllium husk) and on standard treatment. Study Design: Randomized Controlled Trial. Setting: Department of Medicine, Allied Hospital, Faisalabad. Period: 30th November 2022 to 29th May 2023. Material & Methods: A total of 60 type 2 diabetes mellitus patients of both genders, age >18 to 60 years, diagnosed with DM for more than two years, were selected. Patients undergoing insulin therapy, history of DSF allergy, gastrointestinal surgery, and pregnant or lactating women were excluded. Group A received soluble ffibre10.5 g daily for 12 weeks of intervention and standard medications oforDM. Postprandial glucose was checked after 2 hours of meal. In comparison, Group B did not receive any food supplements throughout the intervention period and continued regular diets. The outcome of Blood samples was obtained in terms of mean reduction in postprandial glucose. Results: Mean reduction in Postprandial glucose in Patients with type 2 diabetes mellitus by dietary fibre (psyllium husk) was 14.33 ± 2.04 mmol/l, and in those who are not using dietary fibre (psyllium husk) and on standard treatment, it was 10.83 ± 1.95 mmol/l (p-value = 0.0001). Conclusion: This study concluded that the mean reduction in Postprandial glucose in Patients with type 2 diabetes mellitus by dietary fibre (psyllium husk) is relatively high.

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The Effect of Metamucil on Postprandial Blood Glucose and Plasma Gastric Inhibitory Peptide in Insulin‐dependent Diabetics

Cited by 28 publications

References 15 publications

The acute effects of psyllium on postprandial lipaemia and thermogenesis in overweight and obese men

The acute effects of psyllium on postprandial lipaemia and thermogenesis in overweight and obese men

The postprandial glucose-lowering effect of dietary fiber (Psyllium Husk) in patients with type 2 diabetes mellitus.

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