The effect of menstrual cycle on blood alcohol levels and behavior.

Brick, John; Nathan, Peter E.; Westrick, E.; Frankenstein, William; Shapiro, Allan P.

doi:10.15288/jsa.1986.47.472

Cited by 49 publications

(18 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Contrary to our expectations, the direct effects of ethanol and ethanol consumption did not vary as a function of menstrual cycle phase. This lack of effect is similar to some (Brick et al 1986) but not other (Sutker et al 1987) studies. The present study was conducted in a carefully controlled laboratory environment, and the results suggest that the effects of menstrual cycle on the direct effects of ethanol and ethanol consumption are probably relatively subtle.…”

Section: Discussionsupporting

confidence: 91%

“…For example, Brick et al (1986) reported that ethanol did not have differential effects on measures of memory or body sway at menstruation (when levels of both P and E are low), mid-cycle (when levels of E are high and levels of P are intermediate), and premenstrual (when levels of E and P are declining from intermediate levels) phases. However, another study reported that women performed more poorly on a vigilance task during the follicular phase than the luteal phase (Linnoila et al 1980).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of ethanol at four phases of the menstrual cycle

Holdstock

Wit

2000

Psychopharmacology

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Effects of ethanol at four phases of the menstrual cycle

Holdstock

Wit

2000

Psychopharmacology

View full text Add to dashboard Cite

show abstract

“…Ethanol increased measures of sedation (ARCI PCAG and BAES sedation), stimulation (ARCI A-immediately after ingestion), dysphoria (ARCI LSD), nausea, ratings of feel drug, and decreases in psychomotor (DSST) performance. Similar to some studies (e.g., Brick et al 1986;Holdstock and de Wit 2000), but not to others (e.g., Sutker et al 1987), the subjective and behavioral effects of ethanol did not differ across the menstrual cycle phase.…”

Section: Discussionsupporting

confidence: 85%

Moderate doses of ethanol fail to increase plasma levels of neurosteroid 3α-hydroxy-5α-pregnan-20-one-like immunoreactivity in healthy men and women

Holdstock

Penland²,

Morrow³

et al. 2005

Psychopharmacology

View full text Add to dashboard Cite

3alpha,5alpha-THP-like immunoreactivity levels in human plasma are not increased following moderate ethanol consumption, suggesting that circulating levels of progesterone or its tetrahydro-reduced metabolites do not play a major role in ethanol action. However, the possibility remains that ethanol increases endogenous brain production of GABAergic neurosteroids without affecting plasma levels. Moreover, humans synthesize 5beta-reduced GABAergic steroids, and levels of these steroids may be altered in plasma or brain.

show abstract

“…Indeed, there have been a number of investigations of ethanol pharmacokinetics as a function of menstrual cycle phase in women (Jones and Jones 1976;Hay et al 1984;Brick et al 1986;Cole-Harding and Wilson 1987;Sutker et al 1987a, b). In general, ethanol eliminations were not altered by menstrual cycle phase (Jones and Jones 1976;Hay et al 1984;Brick et al 1986;Cole-Harding and Wilson 1987). This is in agreement with the one study published in macaque monkeys that found no effect of menstrual cycle phase on peak blood ethanol following intubation of low, moderate or high ethanol doses (Mello et al 1984).…”

Section: Discussionmentioning

confidence: 99%

Discriminative stimulus effects of ethanol and 3α-hydroxy-5α-pregnan-20-one in relation to menstrual cycle phase in cynomolgus monkeys ( Macaca fascicularis )

et al. 1997

View full text Add to dashboard Cite

The present study was designed to characterize the discriminative stimulus effects of ethanol and the neurosteroid 3 alpha-hydroxy-5 alpha-pregnan-20-one (allopregnanolone) in nonhuman primates as a function of menstrual cycle phase. Female cynomolgus monkeys (Macaca fascicularis) were trained in a two-lever procedure to discriminate 1.0 g/kg ethanol (IG, 30 min pretreatment) from water using food reinforcement. A cumulative dosing procedure was used to assess changes in the potency of ethanol and an endogenous anxiolytic steroid in the follicular versus the luteal phase of the menstrual cycle. Plasma progesterone and allopregnanolone levels were determined within 24 h of testing to verify phase of menstrual cycle. The monkeys were more sensitive to the discriminative stimulus effects of ethanol and the ethanol-like effects of the endogenous neuroactive steroid allopregnanolone during the luteal phase of the menstrual cycle. These findings suggest that changes in the endogenous levels of ovarian-derived progesterone and allopregnanolone alter sensitivity to the discriminative stimulus effects of ethanol.

show abstract

The effect of menstrual cycle on blood alcohol levels and behavior.

Cited by 49 publications

References 0 publications

Effects of ethanol at four phases of the menstrual cycle

Effects of ethanol at four phases of the menstrual cycle

Moderate doses of ethanol fail to increase plasma levels of neurosteroid 3α-hydroxy-5α-pregnan-20-one-like immunoreactivity in healthy men and women

Discriminative stimulus effects of ethanol and 3α-hydroxy-5α-pregnan-20-one in relation to menstrual cycle phase in cynomolgus monkeys ( Macaca fascicularis )

Contact Info

Product

Resources

About