The effect of menopause on regional and total body lean mass

Douchi, Tsutomu; Yamamoto, Shinako; Nakamura, Sachiko; Ijuin, Tomu; Oki, Toshimichi; Maruta, Kuninori; Nagata, Yukihiro

doi:10.1016/s0378-5122(98)00035-8

Cited by 71 publications

(71 citation statements)

References 17 publications

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“…One of these factors, namely the sudden decline in estrogen levels at the time of menopause seems to play an important role [9][10][11][12]. Results of studies on the effect of hormone therapy (HT) on body composition suggest that postmenopausal estrogen use might be beneficial.…”

Section: Introductionmentioning

confidence: 99%

Soy isoflavones, body composition, and physical performance

et al. 2005

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Objectives: Physiologic changes, occurring during the process of aging, can have serious health consequences, such as increased risk of chronic disease and disability. Decline in estradiol levels after menopause is hypothesized to contribute to this risk. Thus, hormone therapy (HT) might prevent or delay those changes. However, HT has serious side effects and alternative approaches are needed. Methods: We performed a 12-month double-blind randomized trial comparing soy protein containing 99 mg isoflavones (aglycone weights) with milk protein (placebo) daily in 202 postmenopausal women aged 60-75 years. Endpoints were body composition, and physical performance. Randomization resulted in reasonable well-balanced groups, 153 (76%) women completed the trial. Compliance was good (plasma genistein levels 55 ± 101 and 1259 ± 1610 nmol/L for placebo and soy group, respectively). The changes in the endpoints during the intervention period among the two intervention groups were analyzed. Results: Body mass index (BMI) and waist-to-hip ratio did not change during intervention. Handgrip strength at the final visit was slightly worse in the soy group compared to the placebo group (−0.45 kg (95% C.I.: −2.5, 1.6 kg; p = 0.7), but this difference was not statistically significant. Self-reported functional status, mobility and physical performance, all slightly improved during intervention but there were no differences between the groups. Conclusions: The results of the present trial do not support the view that soy isoflavones have favorable effects on body composition and physical performance in postmenopausal women.

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Section: Introductionmentioning

confidence: 99%

Soy isoflavones, body composition, and physical performance

et al. 2005

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“…Additionally, thyroxine (t 4 ) and triiodothyronine (t 3 ) levels as well as growth hormone (GH) decrease as a result of the general ageing process. This dramatic hormonal transition is often associated with weight gain and changes in body composition, in particular fat distribution paterns [34][35][36][37][38][39][40][41]. We can summarize from a proximate viewpoint that menopausal transition is caused by the inal depletion of germ cells and it is characterized by marked hormonal disturbances which are associated with signiicant changes in body composition and fat paterning.…”

Section: Physiology Of Menopause: Proximate Approachmentioning

confidence: 99%

Menopause Female Reproductive Senescence from the Viewpoint of Evolutionary Anthropology

Kirchengast¹

2017

A Multidisciplinary Look at Menopause

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Female reproductive senescence is characterized by the so-called menopausal transition taking place between the ages of 40 and 60 years. The major event of menopausal transition is menopause itself, which is biomedically deined as the cessation of menstrual function and the irreversible termination of female reproductive capability. Recent human females experience a postreproductive period from about 30 years. Such a long postreproductive period is absolutely uncommon among animals. Consequently, human menopause is still an evolutionary puzzle and several theories to explain the evolutionary basis of menopause have been presented. Menopausal transition, however, is also seen as a period of increased somatic and psychic symptoms which make this phase of life quite uncomfortable for afected women. In the present study, menopause and climacteric complaints are discussed from the viewpoint of evolutionary anthropology.

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“…Muscle weakness may harm the quality of life and autonomy of elderly people. The decline of lean body mass that occurs with aging probably includes a decrease in somatotropin (GH) synthesis and secretion due to decreased pituitary response to GHRH, loss of muscle fibers, neuromuscular changes, sedentary lifestyle and other changes intrinsically associated with aging (Douchi et al, 1998). In the pre-menopausal women, the response to GHRH is increased which is not found in the post-menopausal women, suggesting that the age-related decline in GH results in the loss of muscle mass (Douchi et al, 1998).…”

Section: Thin Postmenopausal Womenmentioning

confidence: 99%

“…The decline of lean body mass that occurs with aging probably includes a decrease in somatotropin (GH) synthesis and secretion due to decreased pituitary response to GHRH, loss of muscle fibers, neuromuscular changes, sedentary lifestyle and other changes intrinsically associated with aging (Douchi et al, 1998). In the pre-menopausal women, the response to GHRH is increased which is not found in the post-menopausal women, suggesting that the age-related decline in GH results in the loss of muscle mass (Douchi et al, 1998). Bone loss accelerates substantially in the late perimenopause and continues at a similar pace in the first postmenopausal years (GilletteGuyonnet et al, 2000;Finkelstein J. et al, 2008).…”

Section: Thin Postmenopausal Womenmentioning

confidence: 99%

“…Also the lean body mass and bone mass are decreased, while the fat mass increases in postmenopausal women (android distribution). It however, remains unclear whether the changes are due to age or to menopause (Tremollieres et al, 1996;Douchi et al, 1998;Ijuin H et al, 1999;Wang Q et al, 1994). A longitudinal study showed that a rapid increase in visceral fat mass generally attributed to the aging process (Tchernof et al, 1998).…”

Section: Contribution Of Lean and Fat Mass To Bone Massmentioning

confidence: 99%

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