The effect of Melissa officinalis L. extract on learning and memory: Involvement of hippocampal expression of nitric oxide synthase and brain-derived neurotrophic factor in diabetic rats

Naseri, Mohsen; Mianroodi, Reza Arabi; Pakzad, Zeynab; Falahati, Peiman; Borbor, M; Azizi, Hossein; Nasri, Sima

doi:10.1016/j.jep.2021.114210

Cited by 11 publications

(2 citation statements)

References 36 publications

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“…Similarly, in a rodent model of permanent focal brain ischemia, RA was found to prevent working, spatial and recognition memory deficits, possibly via its synaptogenic (increased expression of synaptophysin and BDNF) and anti-inflammatory (reduced levels of GFAP) activities (Fonteles et al, 2016). In concurrence, Naseri and coworkers observed that RA as the principle phenolic compound in Melissa officianalis could attenuate STZ-induced diminishment of hippocampal BDNF levels, concomitantly with significant enhancements in (working) memory and learning, as assessed by Y-maze and passive avoidance tests (Naseri et al, 2021).…”

Section: Cognitive Impairment Associated Pathological Ageing and Othe...mentioning

confidence: 92%

Molecular mechanisms of neuroprotective offerings by rosmarinic acid against neurodegenerative and other CNS pathologies

Ravaria

Saxena

et al. 2023

Phytotherapy Research

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Rosmarinic acid (RA) is a natural phenolic compound present in culinary herbs of the Boraginaceae, Lamiaceae/Labiatae, and Nepetoideae families. While the medicinal applications of these plants have been known for ages, RA has only been relatively recently established as an effective ameliorative agent against various disorders including cardiac diseases, cancer, and neuropathologies. In particular, several studies have confirmed the neuroprotective potential of RA in multiple cellular and animal models, as well as in clinical studies. The neuroprotective effects mediated by RA stem from its multimodal actions on a plethora of cellular and molecular pathways; including oxidative, bioenergetic, neuroinflammatory, and synaptic signaling. In recent years, RA has garnered tremendous interest as an ideal therapeutic candidate for treating neurodegenerative diseases. This review first briefly discusses the pharmacokinetics of RA and then proceeds to detail the neuroprotective mechanisms of RA at the molecular levels. Finally, the authors focus on the ameliorative potential of RA against several central nervous system (CNS) disorders, ranging from neuropsychological stress and epilepsy to neurodegenerative diseases such as Alzheimer's disease, Huntington's disease, Parkinson's disease, Lewy body dementia, and amyotrophic lateral sclerosis.

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Section: Cognitive Impairment Associated Pathological Ageing and Othe...mentioning

confidence: 92%

Molecular mechanisms of neuroprotective offerings by rosmarinic acid against neurodegenerative and other CNS pathologies

Ravaria

Saxena

et al. 2023

Phytotherapy Research

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“…The extract of M. officinalis ameliorates the learning and memory deficits in scopolamine-injected rats by increasing the time spent in the target quadrant of the Morris water maze test [ 75 ]. M. officinalis can improve long-term memory in the passive avoidance test along with decreased acetylcholinesterase enzyme activity[ 76 ] and increased alterations in the Y-maze test of diabetic rats [ 76 ]. In the carrageenan-induced paw edema model, the inflammation response was decreased significantly in rats treated with M. officinalis leaf extract compared with the drug “indomethacin” [ 77 ].…”

Section: P Athology Of Alzheimer’s Diseasementioning

confidence: 99%

Anti-inflammatory and memory-enhancing properties of Chinese herbal extracts: The possible application in Alzheimer’s disease

Liu¹,

Varinthra²,

Suresh³

et al. 2022

Tzu Chi Medical Journal

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A BSTRACT Alzheimer’s disease (AD) is a progressive brain disease that causes cognitive impairment in seniors. The beta-amyloid (Aβ) deposition and intracellular neurofibrillary tangles are two pathological hallmarks of AD. The increase of AD hallmarks causes inflammatory response enhancement, reduction of synaptic plasticity, and impaired cognition. The percentage of the aging population is growing along with the number of AD patients; however, effective treatment of AD is still limited. Therefore, developing preventive and therapeutic drugs for AD with fewer adverse side effects is urgently needed. The crude extracts from herbs such as Centella asiatica , Dendrobium catenatum , Litsea cubeba , Nardostachys jatamansi , Convolvulus pluricaulis , Melissa officinalis , Magnolia officinalis , Withania somnifera , and Nigella sativa improved memory performance and reduced inflammation response in various diseases. In addition, herbal blends usually have minimum aversive effects and can be mixed into diet and served as nutritional supplements. Hence, it is promising to develop Chinese herbal extracts to prevent or treat early AD. This review article highlights the currently available treatments of AD and the therapeutic effects of a group of crude extracts from Chinese herbs that can prevent cognitive decline and reduce the excessive inflammatory response. The possible clinical use of these Chinese herbal extracts in AD is also discussed.

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Herbal Medicine for Health Management and Disease Prevention

Ghosh,

Adhikary,

Bhattacherjee

et al. 2023

Reference Series in Phytochemistry

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The effect of Melissa officinalis L. extract on learning and memory: Involvement of hippocampal expression of nitric oxide synthase and brain-derived neurotrophic factor in diabetic rats

Cited by 11 publications

References 36 publications

Molecular mechanisms of neuroprotective offerings by rosmarinic acid against neurodegenerative and other CNS pathologies

Molecular mechanisms of neuroprotective offerings by rosmarinic acid against neurodegenerative and other CNS pathologies

Anti-inflammatory and memory-enhancing properties of Chinese herbal extracts: The possible application in Alzheimer’s disease

Herbal Medicine for Health Management and Disease Prevention

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