The effect of melatonin on Hippo signaling pathway in dental pulp stem cells

Baysal, Eylem; Zırh, Elham Bahador; Büber, Esra; Jakobsen, Tambudzai Kanhema; Zeybek, Naciye Dilara

doi:10.1016/j.neuint.2021.105079

Cited by 12 publications

(11 citation statements)

References 36 publications

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“…Additionally, remarkable findings shall be underlined showing that site-specific development and neuronal differentiation can be also achieved by the transfer of stem cells other than NSCs to areas of the CNS. This has been demonstrated with bone marrow MSCs [144], adipose tissue-derived MSCs [145], amniotic fluid MSCs [100], and dental pulp MSCs [102]. In the two latter cases, the MSCs were more specifically differentiated to dopaminergic cells, as judged by the expression of tyrosine hydroxylase [100,102].…”

Section: Neurogenesis From Nscs/nspcsmentioning

confidence: 83%

“…This has been demonstrated with bone marrow MSCs [144], adipose tissue-derived MSCs [145], amniotic fluid MSCs [100], and dental pulp MSCs [102]. In the two latter cases, the MSCs were more specifically differentiated to dopaminergic cells, as judged by the expression of tyrosine hydroxylase [100,102]. From a fundamental point of view, this sheds light on the role of the tissue-specific microenvironment, which may include the locally residing neurons and astrocytes, their secreted factors, and presumably also the composition of the extracellular matrix.…”

Section: Neurogenesis From Nscs/nspcsmentioning

confidence: 85%

“…Reprogramming to NSCs and neurons deriving thereof has also been demonstrated for MSCs [100][101][102]. In particular, amniotic fluid MSCs [100] and dental pulp MSCs [102] were shown to differentiate into dopaminergic neurons under the influence of mixtures of neurotrophic factors and/or melatonin, findings of particular interest to the therapy of Parkinson's disease. In the MSCs from amniotic fluid, melatonin induced changes in surface markers, reducing the expressions of CD29, CD45, CD73, CD90, and CD105 [100].…”

Section: Reprogramming Of Skin Fibroblasts and Other Cells To Nscsmentioning

confidence: 88%

“…In the MSCs from amniotic fluid, melatonin induced changes in surface markers, reducing the expressions of CD29, CD45, CD73, CD90, and CD105 [100]. In the dental pulp MSCs (DPMSCs), melatonin caused upregulations in neuronal markers and in tyrosine hydroxylase [102]. Additionally, it promoted the phosphorylation of a decisive transcription factor in Hippo signaling, YAP (Yes-associated protein), at Y357, a change that causes cytoplasmic retention and proteasomal degradation of this factor.…”

Section: Reprogramming Of Skin Fibroblasts and Other Cells To Nscsmentioning

confidence: 99%

“…Additionally, it promoted the phosphorylation of a decisive transcription factor in Hippo signaling, YAP (Yes-associated protein), at Y357, a change that causes cytoplasmic retention and proteasomal degradation of this factor. Since unphosphorylated YAP, in conjunction with its association partner TAZ (transcriptional co-activator with PDZ binding motif), supports stemness and self-renewal [103], the also observed reduction of the stem cell marker nestin [102] is highly plausible. The effect of melatonin on Hippo/YAP signaling is also of interest to other properties and actions of melatonin, because of a considerable overlap and antagonism.…”

Section: Reprogramming Of Skin Fibroblasts and Other Cells To Nscsmentioning

confidence: 99%

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Melatonin and the Programming of Stem Cells

Hardeland

2022

IJMS

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Melatonin interacts with various types of stem cells, in multiple ways that comprise stimulation of proliferation, maintenance of stemness and self-renewal, protection of survival, and programming toward functionally different cell lineages. These various properties are frequently intertwined but may not be always jointly present. Melatonin typically stimulates proliferation and transition to the mature cell type. For all sufficiently studied stem or progenitor cells, melatonin’s signaling pathways leading to expression of respective morphogenetic factors are discussed. The focus of this article will be laid on the aspect of programming, particularly in pluripotent cells. This is especially but not exclusively the case in neural stem cells (NSCs) and mesenchymal stem cells (MSCs). Concerning developmental bifurcations, decisions are not exclusively made by melatonin alone. In MSCs, melatonin promotes adipogenesis in a Wnt (Wingless-Integration-1)-independent mode, but chondrogenesis and osteogenesis Wnt-dependently. Melatonin upregulates Wnt, but not in the adipogenic lineage. This decision seems to depend on microenvironment and epigenetic memory. The decision for chondrogenesis instead of osteogenesis, both being Wnt-dependent, seems to involve fibroblast growth factor receptor 3. Stem cell-specific differences in melatonin and Wnt receptors, and contributions of transcription factors and noncoding RNAs are outlined, as well as possibilities and the medical importance of re-programming for transdifferentiation.

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