The Effect of Medical Treatment on Patients with Fistulizing Crohn's Disease: A Retrospective Study

Uza, Norimitsu; Nakase, Hiroshi; Ueno, S.; Inoue, Satoko; Mikami, Shuji; Tamaki, Hiroyuki; Matsuura, Minoru; Chiba, Tsutomu

doi:10.2169/internalmedicine.47.0537

Cited by 16 publications

(18 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Following discontinuation of cipro, three of the four responders underwent recurrence. Uza et al (29) carried out a combination therapy of cipro, metro and azathioprine to 10 patients with fistulizing CD. Complete responses were observed in all six patients with external fistulas, and in only one of four patients with internal fistulas.…”

Section: Discussionmentioning

confidence: 99%

Meta-analysis of ciprofloxacin in treatment of Crohn's disease

Wang

2014

Biomedical Reports

View full text Add to dashboard Cite

The aim of the present study was to evaluate the efficacy of ciprofloxacin (cipro) for the treatment of Crohn's disease (CD) through a meta-analysis of randomized controlled trials. The PubMed, Embase and Cochrane Library databases were searched up to May 2014, with no language restrictions, for randomized placebo-controlled trials. Additional references were obtained from the reviewed studies. Five studies were in accordance with the criteria and were included in the meta-analysis. The pooled risk ratio (RR) of all the studies was 1.35 [95% confidence interval (CI), 1.03-1.76; P=0.03]. In three studies, cipro was used for the treatment of CD with perianal fistula and the pooled RR was 1.66 (95% CI, 1.16-2.39; P=0.006). In two studies, cipro was used to treat active CD and the pooled RR was 1.13 (95% CI, 0.77-1.66; P=0.54). Thus in conclusion, cipro exhibits a significant efficacy for the treatment of CD, in particular with perianal fistula.

show abstract

Section: Discussionmentioning

confidence: 99%

Meta-analysis of ciprofloxacin in treatment of Crohn's disease

Wang

2014

Biomedical Reports

View full text Add to dashboard Cite

show abstract

“…Combined treatment with antibiotics and immunomodulators may be a suitable initial therapy for CD patients with external fistulas. TNF-α blocking agents can also be used as an additional therapy in the treatment of corticosteroid dependent, refractory cases or in complicated extraintestinal manifestations [10] . This case report demonstrates the potential efficacy of adalimumab in the management of complicated fistulizing CD and/or pyoderma gangrenosum.…”

Section: Discussionmentioning

confidence: 99%

Successful use of adalimumab for treating fistulizing Crohn's disease with pyoderma gangrenosum: Two birds with one stone

Zöld¹,

Nagy²,

Dévényi³

et al. 2009

WJG

View full text Add to dashboard Cite

Crohn's disease (CD) is a chronic relapsing and remitting autoinflammatory disorder of the gastrointestinal tract that has many intestinal and extraintestinal complications. The purpose of treatment is long-term remission, reduction of complications, and improvement of patients' quality of life. In many cases, this can be quite challenging and it is necessary to have a well thought out management strategy. We present the case of a 38-year-old woman with fistulizing CD that manifested as diffuse abdominal pain and bloody diarrhea accompanied by arthralgia. In addition, there were ulcerative lesions surrounded by cutaneous inflammation and erythema on her extremities, indicative of pyoderma gangrenosum. The patient was treated with high doses of parenteral methylprednisolone without any improvement and was started on adalimumab. A positive response to adalimumab therapy was observed: after 2 mo of therapy, the ulcerative skin lesion healed completely and the enterogastric fistula was closed after 5 mo adalimumab treatment. Adalimumab might be a suitable initial as well as maintenance therapy in patients with complicated CD.

show abstract

“…Some immunosuppressive agents and anti-TNF-α therapy are commonly used in treatment. In some studies, anti-TNF-α has been commended vigorously (7). Surgical resection is required for symptomatic internal fistulas.…”

Section: Most Of Enteroduodenal Fistulas Arise From the Recurrent Dismentioning

confidence: 99%

A rare complication of Crohn disease: Duodenocolic fistula

Bora¹,

Sonbahar²,

Özalp³

2017

Turk J Gastroenterol

View full text Add to dashboard Cite

tween the third portion of duodenum and ileotransverse anastomosis (Figure 1). We also performed barium ABSTRACTCrohn disease (CD) is a chronic inflammatory disease that may be observed in random areas of gastrointestinal tract. Fistula formation is common during the course of CD, whereas duodenocolic fistulas are very rare. It is possible to safely perform surgical resection in patients who have severe symptoms of duodenal fistula. In this study, we report a rare case of CD with duodenocolic fistula that has emerged from the previous surgical resection.

show abstract

The Effect of Medical Treatment on Patients with Fistulizing Crohn's Disease: A Retrospective Study

Abstract: Background Fistulas are a major complication of Crohn's disease (CD)

Cited by 16 publications

References 32 publications

Meta-analysis of ciprofloxacin in treatment of Crohn's disease

Meta-analysis of ciprofloxacin in treatment of Crohn's disease

Successful use of adalimumab for treating fistulizing Crohn's disease with pyoderma gangrenosum: Two birds with one stone

A rare complication of Crohn disease: Duodenocolic fistula

Contact Info

Product

Resources

About