The effect of mechanical stimulation on the maturation of TDSCs-poly(L-lactide-co-e-caprolactone)/collagen scaffold constructs for tendon tissue engineering

Xu, Yuan; Dong, Shiwu; Zhou, Qiang; Mo, Xiumei; Song, Lei; Hou, Tianyong; Wu, Jinglei; Li, Songtao; Li, Yudong; Li, Pei; Ye, Gan; Xu, Jianzhong

doi:10.1016/j.biomaterials.2013.12.042

Cited by 101 publications

(84 citation statements)

References 43 publications

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“…Dynamic liquid electrospinning has been successfully used to create highly porous scaffolds of aligned nanofibers [141][142][143][144]. These scaffolds, called nanoyarn scaffolds, are created by collecting fibers in a water reservoir instead of a target.…”

Section: Dynamic Liquid Electrospinningmentioning

confidence: 99%

“…The completed scaffold is then removed from the mandrel, frozen at −80 ∘ C for 2 hours and then lyophilized overnight, creating a highly porous sheet of aligned nanoyarn [141]. The scaffolds created with this technique have applications with tissues, such as tendons, that have a naturally aligned ECM structure [143,144].…”

Section: Dynamic Liquid Electrospinningmentioning

confidence: 99%

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A review of electrospinning manipulation techniques to direct fiber deposition and maximize pore size

et al. 2017

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Electrospinning has been widely accepted for several decades by the tissue engineering and regenerative medicine community as a technique for nanofiber production. Owing to the inherent flexibility of the electrospinning process, a number of techniques can be easily implemented to control fiber deposition (i.e. electric/magnetic field manipulation, use of alternating current, or air-based fiber focusing) and/or porosity (i.e. air impedance, sacrificial porogen/sacrificial fiber incorporation, cryo-electrospinning, or alternative techniques). The purpose of this review is to highlight some of the recent work using these techniques to create electrospun scaffolds appropriate for mimicking the structure of the native extracellular matrix, and to enhance the applicability of advanced electrospinning techniques in the field of tissue engineering.

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Section: Dynamic Liquid Electrospinningmentioning

confidence: 99%

Section: Dynamic Liquid Electrospinningmentioning

confidence: 99%

A review of electrospinning manipulation techniques to direct fiber deposition and maximize pore size

et al. 2017

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“…In a follow-up study, tendon-derived stem cells (TDSCs) were harvested from rabbit patellar tendons and seeded onto the fibrous scaffolds [48]. In vitro and in vivo assessment under static and dynamic conditions revealed that the composite scaffolds seeded with TDSCs were a promising means for neotendon formation.…”

Section: Mpamentioning

confidence: 99%

“…% hyaluronic acid [48] In vitro ( fibroblast) In vivo (rat) to achieve a more efficient sericin removal. This resulted in smoother fibre surfaces and preserved the general mechanical properties of the silk.…”

Section: Mpamentioning

confidence: 99%

Advances in Tendon and Ligament Tissue Engineering: Materials Perspective

Alshomer

Chaves

Kalaskar

2018

Journal of Materials

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Introduction. Tendons are specialised, heterogeneous connective tissues, which represent a significant healthcare challenge after injury. Primary surgical repair is the gold standard modality of care; however, it is highly dependent on the extent of injuries. Tissue engineering represents an alternative solution for good tissue integration and regeneration. In this review, we look at the advanced biomaterial composites employed to improve cellular growth while providing appropriate mechanical properties for tendon and ligament repair. Methodology. Comprehensive literature searches focused on advanced composite biomaterials for tendon and ligament tissue engineering. Studies were categorised depending on the application. Results. In the literature, a range of natural and/or synthetic materials have been combined to produce composite scaffolds tendon and ligament tissue engineering. In vitro and in vivo assessment demonstrate promising cellular integration with sufficient mechanical strength. The biological properties were improved with the addition of growth factors within the composite materials. Most in vivo studies were completed in smallscale animal models. Conclusions. Advanced composite materials represent a promising solution to the challenges associated with tendon and ligament tissue engineering. Nevertheless, these approaches still demonstrate limitations, including the necessity of larger-scale animal models to ease future clinical translation and comprehensive assessment of tissue response after implantation.

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“…A scaffold fills a defect or gap in a tendon, taking on much of the tendon's mechanical load until the tissue heals and the scaffolds degrades [12]. These scaffolds may also mimic the environment of uninjured tendon, guiding the differentiation of seeded cells [13].…”

Section: Introductionmentioning

confidence: 99%

Biologic and Tissue Engineering Strategies for Tendon Repair

Sigal

Grande

Dines

et al. 2016

Regen. Eng. Transl. Med.

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This review summarizes recent developments in biologic treatments-including growth factors, platelet-rich plasma (PRP), stem cells, and cell-seeded scaffolds-for tendon repair. Growth and differentiation faction-5 (GDF-5), insulin-related growth factor-1 (IGF-1), and basic fibroblast growth factor (bFGF) all improved extracellular matrix (ECM) production and tensile strength of treated tendons; however, no clinical trials were done on GDF-5. Platelet-derived growth factor-BB (PDGF-BB) improved proliferation and ECM production, but did not consistently improve mechanical properties. The literature was mixed on the efficacy of PRP for the treatment of chronic and acute tendinopathies. However, PRP did cause any complications, and its benefits may be enhanced once an ideal, standardized composition is developed. Therefore, PRP may be a valid treatment, especially once nonsurgical management options have failed. Mesenchymal stem cells (MSCs) significantly and substantially improved the quality of tendon repairs and demonstrated the ability to regenerate an enthesis. Adipose-derived stem cells (ADSCs) have similar effects and are easier to harvest. The periosteum may also regenerate the tendon-bone attachment. Tenocytes, meanwhile, may be ideal for midsubstance tendon repairs. Cell-seeded scaffolds-especially ECMderived scaffolds-were demonstrated to improve ECM production, enhancing the healing abilities of tenocytes or stem cells while providing early mechanical support to healing tendons.Each of these treatments demonstrated enhanced healing compared to common surgical techniques; moreover, patient outcomes may be enhanced by combining these treatments. Lay SummaryTendon injuries are very prevalent and can be debilitating. Tendon heals poorly, and the scar tissue that forms is weak and susceptible to reinjury. A major focus of orthopedic research is regenerative medicine, encouraging the formation of healthy tendon rather than mechanically inferior scar tissue. This review summarizes the recent scientific literature on biologic treatments for tendon repair, such as growth factors, platelet-rich plasma, and stem cells. The purpose of which is to show which treatments are promising candidates for clinical use and research, helping to guide physicians and to lay out a path for future research.

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The effect of mechanical stimulation on the maturation of TDSCs-poly(L-lactide-co-e-caprolactone)/collagen scaffold constructs for tendon tissue engineering

Cited by 101 publications

References 43 publications

A review of electrospinning manipulation techniques to direct fiber deposition and maximize pore size

A review of electrospinning manipulation techniques to direct fiber deposition and maximize pore size

Advances in Tendon and Ligament Tissue Engineering: Materials Perspective

Biologic and Tissue Engineering Strategies for Tendon Repair

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