“…In this context, several studies have shown that mechanical stimuli including cyclic mechanical tension, low-intensity pulsed ultrasound (LIPUS), uniaxial mechanical stretch and cyclic uniaxial compressive stress are able to induce the proliferation of DPSCs ( Han et al, 2008 ; Hata et al, 2012 ; Gao et al, 2016 , 2017 ; Yang et al, 2017 ). Furthermore physical stimuli such as loading, surface topographies, dynamic hydrostatic pressure and pulsating fluid flow can reportedly promote the differentiation of DPSCs (see Table 1 and Figure 1 ) ( Han et al, 2008 , 2010 ; Yu et al, 2009 ; Kraft et al, 2010 , 2011 ; Lee et al, 2010 ; Ji et al, 2014 ; Kolind et al, 2014 ; Tabatabaei et al, 2014 ; Miyashita et al, 2017 ; Yang et al, 2017 ). Several investigations have also shown that mechanical stimuli including dynamic hydrostatic pressure, cyclic tensile strain, mechanical compression and cyclic uniaxial compressive strain can promote the odontogenic differentiation of DPSCs ( Yu et al, 2009 ; Lee et al, 2010 ; Miyashita et al, 2017 ; Yang et al, 2017 ).…”