The Effect of Measles-Rubella Vaccination on Lymphocyte Populations and Subpopulations in HIV-Infected and Healthy Individuals

Nicholson, Janet K. A.; Holman, Robert C.; Jones, Bonnie M.; McDougal, J S; Sprauer, Mary Ann; Markowitz, Lauri E.

doi:10.1097/00126334-199205000-00016

Cited by 4 publications

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“…In a study of HIV-infected children in New York City, the level of circulating HIV p24 antigen increased following measles virus infection in three children with preexisting p24 antigen but not in eight HIV-infected children after measles immunization [9]. The effect of measles and rubella vaccination on lymphocyte subpopulations was studied among 39 HIVinfected adults and 17 hospital workers who served as controls [48,65]. The percentage of CD8 ϩ T lymphocytes decreased in both groups 3 weeks after immunization, but the percentage of CD4 ϩ T lymphocytes did not change [65].…”

Section: Effect Of Measles and Measles Immunization On Progression Ofmentioning

confidence: 99%

“…The effect of measles and rubella vaccination on lymphocyte subpopulations was studied among 39 HIVinfected adults and 17 hospital workers who served as controls [48,65]. The percentage of CD8 ϩ T lymphocytes decreased in both groups 3 weeks after immunization, but the percentage of CD4 ϩ T lymphocytes did not change [65]. HIV p24 antigen was detected in three persons before and after measles immunization but was undetectable in the remaining vaccine recipients [48].…”

Section: Effect Of Measles and Measles Immunization On Progression Ofmentioning

confidence: 99%

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Implications of the Human Immunodeficiency Virus Epidemic for Control and Eradication of Measles

Moss¹,

Cutts²,

Griffin³

1999

CLIN INFECT DIS

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Human immunodeficiency virus (HIV)-infected persons may be important, unrecognized transmitters of measles virus, thwarting eradication efforts. We reviewed the published English-language literature on measles and measles immunization in HIV-infected persons to investigate the clinical features of measles, the responses to measles immunization, and the safety of measles vaccine in HIV-infected persons and, conversely, the effect of measles and measles immunization on HIV infection. HIV-infected persons with measles are likely to have uncharacteristic clinical findings and severe illness, with high rates of pneumonitis and death. Primary and secondary failure of measles vaccine in HIV-infected children may permit transmission of measles virus in spite of high rates of immunization coverage. A factor that complicates measles-control efforts in areas of high prevalence of HIV is the potential for fatal infection with measles vaccine virus. Further research on the impact of the HIV epidemic on measles and measles immunization is necessary to guide strategies for the eradication of measles.

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Section: Effect Of Measles and Measles Immunization On Progression Ofmentioning

confidence: 99%

Section: Effect Of Measles and Measles Immunization On Progression Ofmentioning

confidence: 99%

Implications of the Human Immunodeficiency Virus Epidemic for Control and Eradication of Measles

Moss¹,

Cutts²,

Griffin³

1999

CLIN INFECT DIS

View full text Add to dashboard Cite

show abstract

Measles, Mumps, and Rubella Serostatus and Response to MMR Vaccination Among HIV-Infected Adults

Kaur

ChiuYa-Lin²,

WilkinTimothy

2015

AIDS Patient Care and STDs

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Measles Seroprevalence and Vaccine Responses in Human Immunodeficiency Virus–infected Adolescents and Adults: A Systematic Review

Loevinsohn

Rosman

Moss

2018

Clinical Infectious Diseases

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Background The World Health Organization (WHO) recommends an additional dose of measles-containing vaccine (MCV) for human immunodeficiency virus (HIV)–infected children receiving highly active antiretroviral therapy following immune reconstitution. We conducted a systematic review to synthesize available evidence regarding measles seroprevalence and measles vaccine immunogenicity, efficacy, and safety in HIV-infected adolescents and adults to provide the evidence base for recommendations on the need for measles vaccination. Methods We conducted searches of 8 databases through 26 September 2017. Identified studies were screened independently by 2 reviewers. Results The search identified 30 studies meeting inclusion criteria. Across studies, measles seroprevalence among HIV-infected adolescents and adults was high (median, 92%; 27 studies), with no significant difference compared to HIV-uninfected participants (10 studies). In 6 studies that evaluated the immunogenicity of MCVs among seronegative HIV-infected adults, measles seropositivity at end of follow-up ranged from 0% to 56% (median, 39%). No severe adverse events were reported following measles vaccination in HIV-infected patients. Conclusions Based on similar measles seroprevalence between HIV-infected and HIV-uninfected adolescents and adults, and the low response to vaccination, these studies do not support the need for an additional dose of MCV in HIV-infected adolescents and adults. These findings support WHO guidelines that measles vaccine be administered to potentially susceptible, asymptomatic HIV-infected adults, and may be considered for those with symptomatic HIV infection if not severely immunosuppressed. Measles-susceptible adolescents and adults, regardless of HIV status, may require targeted vaccination efforts to reach critical vaccination thresholds and achieve regional elimination goals.

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The Effect of Measles-Rubella Vaccination on Lymphocyte Populations and Subpopulations in HIV-Infected and Healthy Individuals

Cited by 4 publications

References 0 publications

Implications of the Human Immunodeficiency Virus Epidemic for Control and Eradication of Measles

Implications of the Human Immunodeficiency Virus Epidemic for Control and Eradication of Measles

Measles, Mumps, and Rubella Serostatus and Response to MMR Vaccination Among HIV-Infected Adults

Measles Seroprevalence and Vaccine Responses in Human Immunodeficiency Virus–infected Adolescents and Adults: A Systematic Review

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